Swale: Are SARMs being discussed among your peers?

[Random987]

There have been a couple of posts in the last couple of days indicating that Selective Androgen Receptor Modulators may be the next wave of TRT (or at least something people should look at). If you could take a pill for the postivie aspects of test, but not have to deal with the unpleasant side affects because of the selectiveness of the molocule, wouldn't this be the best of both worlds?

I was wondering if there has been any discussion at the upper levels of practictioners of TRT.

 

[SWALE]

I have not heard anything mentioned yet. Perhaps they will be addressed at the American Academy of Anti-Aging Medicine International Congress next month in Chicago. I am on board for a couple of lectures there I guess.

 

[maxzax]

What ways are there to deal with SARMs? Are there drugs or herbs capable of helping enhance recptors?

That's itneresting.

There have been a couple of posts in the last couple of days indicating that Selective Androgen Receptor Modulators may be the next wave of TRT (or at least something people should look at). If you could take a pill for the postivie aspects of test, but not have to deal with the unpleasant side affects because of the selectiveness of the molocule, wouldn't this be the best of both worlds?

I was wondering if there has been any discussion at the upper levels of practictioners of TRT.

 

[HeadDoc]

the company developing the sarm is doing alot of good work in men's health. Take a look at what they are going for prostate cancer.

http://www.gtxinc.com/tech/over.htm

 

[SWALE]

Their work is encouraging to us all.

 

[maxzax]

Thanks Head Doc!

the company developing the sarm is doing alot of good work in men's health. Take a look at what they are going for prostate cancer.

http://www.gtxinc.com/tech/over.htm

 

[Random987]

Here is an interesting article. It appears the Ligand Pharmaceuticals is also doing some work on this front. However, given the "pipeline" real useful drugs will not be vailable to the public for quite some time. 5-10 years is my guess. But I now think the men's health movement is picking up some steam in more "mainstream" medicine.

http://jcem.endojournals.org/cgi/content/full/84/10/3459

 

[HeadDoc]

great find. thanks.

 

[Random987]

great find. thanks.

I agree. I love "Chart 1" where they can pick the "desired profile of activity". So you can have a SARM that stimulates the libido, hair growth, bone growth, muscle growth, increase fat free mass, stimulates the "sex accessory tissues", but is netural on lipids, blood pressure, fluid retention, liver function, estrogens (hopefully), etc.

I did a little more research and Ligand Pharm. has a deal with TAP Pharm (the marketers for Prevacid) to market the new product. Given Tap's history with Prevacid that is certainly "mainstream" and it appears the SARMs are being given a lot of attention by the "big boys."



Prostate/sex accessory tissues Stimulatory, but less than DHT Weak or neutral
Libido Stimulatory Stimulatory/neutral
Inhibition of gonadotropins Present Absent/reduced
Hair growth Stimulatory Neutral
Bone growth Stimulatory Stimulatory
Muscle mass/strength Stimulatory Stimulatory
Fat-free mass Increase Increase
Lipids/cardiovascular risk factors Neutral Neutral/beneficial
Blood pressure/fluid retention Neutral Neutral
Erythropoiesis Weakly stimulatory Stimulatory
Liver function (enzyme elevation) Neutral Neutral
Breast (gynecomastia) Neutral Neutral

 

[Axl]

Too bad it isnn't on the market yet. My endo told me that my body does not have much Androgen Receptor, hence my low testosterone (and my juvenile looks).

Could it increase the number of Androgen Receptors in the body??

 

[maxzax]

I don't know of a test for the amount of androgen receptors available. But I have read increasing T and HGH will help with androgen receptors.

Too bad it isnn't on the market yet. My endo told me that my body does not have much Androgen Receptor, hence my low testosterone (and my juvenile looks).

Could it increase the number of Androgen Receptors in the body??

 

[Random987]

I just stumbled on this which seems to suggest that ARs can be "created" through use of exogenous T

http://www.thinkmuscle.com/articles/haycock/androgen-receptors-02.htm

I don't know of a test for the amount of androgen receptors available. But I have read increasing T and HGH will help with androgen receptors.

 

[greatgro]

Too bad it isnn't on the market yet. My endo told me that my body does not have much Androgen Receptor, hence my low testosterone (and my juvenile looks).

If you had less receptors you'd have less testosterone getting to your muscles and target tissues but you won't have low testosterone levels. And how does he know you have less receptors? Honestly it sounds like your Endo doesn't have a clue what he's talking about and that would scare the crap out of me!

 

[SWALE]

Yes, what is then being discussed is the state of androgen receptor resistance. Its hallmark is both high levels of the T, but also of LH, but the symptoms of low T.