Effects of testosterone and nandrolone on cardiac function: a randomized, placebo-controlled study (attached).
Thanks for posting the entire thing.
thanks.
this shows the 4 week LVH on 200mg of test is not remarkable at all.
I am all for studies/safety but this seems like a "big scare" article.
I think you are missing the point.
Do you really think that injecting anything four times is going to result in a massive, failing heart?
The point here is that four injections at what is considered here a low dose made some things relating to heart function move in the wrong direction.
"However, a mild increase in the endsystolic diameter of the LV and RV was seen in the testosterone group. The observed small increases in chamber sizes were within accepted normal ranges for healthy young men and do not have immediate clinical significance." Translation: There was an increase after only four shots, but not enough to drive it up into the range where we would be clinically concerned.
Well, of course not. It was only 4 injections.
Then there is this.
"Recent refinements of echocardiographic colour TDI derived parameters have allowed detection of early subclinical changes on cardiac filling and myocardial velocities.68,69 A reduction in mitral annular Sm velocity is a sensitive marker of mildly impaired LV systolic function even in patients with apparently ‘normal’ LVEF and is reduced in LV diastolic dysfunction.69 When combined with the mitral inflow E wave, the derived E/Em ratio is useful to estimate the LV filling pressures.32,33 While the LVEF was within normal limits in both androgen groups, minor reduction of mitral annular Em velocity and elevation of E/Em ratio were observed in the testosterone group. These changes suggest a mildly adverse effect of testosterone on LV diastolic function. Whether these effects would translate to changes in overall cardiac structure and LVEF after prolonged exposure to androgens remain unclear. Longer-term studies incorporating these colour TDI derived parameters will be required to assess whether these changes persists, increase, resolve or become clinically significant."
Translation: Heart function went the wrong way here in the testosterone group, even though this was only 4 injections. It went the wrong way, but in 4 weeks it did not go the wrong way far enough to be outside the normal range. We'd like to see a longer study, to see if it would continue, but we did not have enough $$$ to go longer than 4 weeks. Maybe somebody reading this will give us a grant. Going past 4 weeks might tell us whether this would continue going in the wrong direction until it would "become clinically significant."
There are points here not to be missed.
If you had asked me prior to reading this whether 4 injections once a week of 200mg of testosterone would have had any negative effects on the heart that researchers could detect, I would have laughed in your face. Now, I wouldn't, because, well, there it is.