Tesamorelin bac ratio

[undersc0re]

I have 10mg vials of tesa, I am just going to start by adding 1.5 ml to my first vial and go with 1mg once a day until it is done. If things are good I will step it up to 2mg per inj and prob go up to 2.5 on the third vial and stay at that. I just have questions relating to this, I don’t really want to subq more than .2ml at a time, what is a suggested maximum subq volume amount for water/peptides? Can 10mg of tesa be ok with only .5 ml of bac or will there be a concentration/irritation and absorption issue?

 

[Ghoul]

I have 10mg vials of tesa, I am just going to start by adding 1.5 ml to my first vial and go with 1mg once a day until it is done. If things are good I will step it up to 2mg per inj and prob go up to 2.5 on the third vial and stay at that. I just have questions relating to this, I don’t really want to subq more than .2ml at a time, what is a suggested maximum subq volume amount for water/peptides? Can 10mg of tesa be ok with only .5 ml of bac or will there be a concentration/irritation and absorption issue?

Big mistake. The standard 2mg dose should not be diluted to less than .5ml. 3ml into the vial and .6ml doses even better.

 

[undersc0re]

well, I guess with one dose missing only the math will be easy. I didn’t think it had to be diluted that much, crazy. No burning, itching, or redness yet….but I am sure its more of an absorption over time issue.

 

[Ghoul]

well, I guess with one dose missing only the math will be easy. I didn’t think it had to be diluted that much, crazy. No burning, itching, or redness yet….but I am sure its more of an absorption over time issue.

Tesa is one of the most immunogenic peptides, and prone to aggregation. Those two factors make the risk of developing immunity to it very high.

The company that makes the name brand, Egrifta, tried to release a more concentrated version to reduce the injection volume, but the FDA put the brakes on it because they were concerned with immunity developing as I described.

 

[Ghoul]

https://www.theratech.com/news-releases/news-release-details/theratechnologies-submits-updated-tesamorelin-f8-formulation

 

[undersc0re]

Thats crazy, I guess I will just have to subq whats needed. I will do some more research, thank you so much for this information, the volume they suggest must be safe to inject then

 

[Ghoul]

Thats crazy, I guess I will just have to subq whats needed. I will do some more research, thank you so much for this information, the volume they suggest must be safe to inject then

I use .6ml daily without issue.

I also .22um filter, and backload into BD veo 6mm syringes for a painless injection, while reducing the risk of drug neutralizing immunogenicity from developing (by filtering out aggregates). I can feel the difference with filtered injections.

 

[undersc0re]

I use .6ml daily without issue.

I also .22um filter, and backload into BD veo 6mm syringes for a painless injection, while reducing the risk of drug neutralizing immunogenicity from developing (by filtering out aggregates). I can feel the difference with filtered injections.

I am working on the filter issue, hopefully have everything by the 3rd vial. Now I have to order insulin syringes larger than .3 ml lol. I was loving the .3ml syringes, they don’t get air in them nearly as bad as the others.
When you back load the larger syringes is air an issue, it seems like the .3ml don’t like the back fill, they get all sorts of air pockets, just doesn’t flow in smoothly in a small syringe…I can work the air bubbles out.

 

[Ghoul]

I am working on the filter issue, hopefully have everything by the 3rd vial. Now I have to order insulin syringes larger than .3 ml lol. I was loving the .3ml syringes, they don’t get air in them nearly as bad as the others.
When you back load the larger syringes is air an issue, it seems like the .3ml don’t like the back fill, they get all sorts of air pockets, just doesn’t flow in smoothly in a small syringe…I can work the air bubbles out.

Backfilling takes a bit of practice, I wish there was an easier way.

So I keep a needle attached to the filter, I don't put the 3ml syringe flush against the insulin syringe which allows liquid to flow better.

Once I reach .6ml. I put the plunger just barely into the insulin syringe. Flip it needle side up, whack it with my finger to knock the air bubble to the top, remove cap and push air out.

After a few times (and messes), I got it down perfectly.

A skill well worth learning.