AlphaLife
Member
No. Do you?
This was actually a response to a post by a more experienced member. Why didn't you ask him?
MESO-Rx
Anabolic Steroids
Testing IGF-1 levels on Black Top Meditrope
- Thread starter mands
- Start date
No. Do you?
This was actually a response to a post by a more experienced member. Why didn't you ask him?
If you want the most growth from it, every day multiple GH shoots...
To safe money ok no problem..
But about suppressing the natural GH?!
It's worthless because you take multiple GH shoots every day!
Like 5 times 3 IU over the day...
Then you DON'T have to worry about your natural GH pulse
To safe money ok no problem..
But about suppressing the natural GH?!
It's worthless because you take multiple GH shoots every day!
Like 5 times 3 IU over the day...
Then you DON'T have to worry about your natural GH pulse
Who says you get the most with multiple injection?
BigAli
New Member
I'll start my log as soon as I get my new GH package. I've already done my baseline and serum test for Saizen and will share it soon.
It's most likely all personal preference and I would say over time multiple shots and one shot a day either day or night strictly from a IGF-1 level will probably yield similar results.
I do know 10 iu's spilt during the day vs. 10 iu's on shot yields a little lower igf-1 level and slower getting to peak level.
I have seen a study about multiple shots being superior to one but I don't think it was concerning igf-1 levels per say.
I will look.
mands
I do know 10 iu's spilt during the day vs. 10 iu's on shot yields a little lower igf-1 level and slower getting to peak level.
I have seen a study about multiple shots being superior to one but I don't think it was concerning igf-1 levels per say.
I will look.
mands
BigAli
New Member
Do you have a study that will prove this? That multiple shots a day would worth the pins and hassle and money vs one shot/day?
people have done many logs that e.g if you split your AAS dose it will give you a higher T level than one single shot per week. Now if you can prove that multiple shots and lower dosage would give you the same IGF1 levels then that would save us a lot of money specially on pharma grade GH.
IGF-1 increases gradually over the time as long as you take GH shots almost everyday.
BigAli
New Member
Beacuase IGF-1 level (if you even consider it as a sole anabolic matter) depends on many factors like genes, estrogen levels, being on cycle or not, amount of meat one consumes etc. There should be lots and lots of tests, bloodwork and logs so we all get to an idea of what the best protocol and level for optimal results would be. e.g in one study subjects took SERMs(tamoxifen) while on GH and it reduced the IGF-1 levels by almost +30 percent.
Kash89
Member
then what the fuck are you coming in here telling people they're wrong and run a log on your 3rd post ever on meso? and you still didnt answer my question? how is it wrong? and if it is wrong why should I log it? I obviously was talking to mands and trying to figure out what was his best protocol, how can that be wrong? I know there are many variables and everyone's result vary and?
PS there is a new member introduction thread, check it out
There is no single best strategy … it depends a lot on your individual situation...blood work is a good indicator.
(3ius, 5 times a day will disrupt the daily natural pulse)
The body produces GH in a pulsatile fashion throughout the day, with the heaviest pulses occurring approximately 2-3 hours after going to bed as you fall into a deep sleep (REM). Unless you suffer from a deficiency (aGHD) the best time to inject would be very early, to early a.m. This will be the least disruptive time to take an injection as exogenous GH will temporary suppress the natural GH pulse
If you are splitting your doses, early a.m. and early afternoon (post workout) when cortisol levels are at peak. Cortisol is very catabolic. GH can have a blunting effect.
Someone suffering from Growth Hormone Deficiency (low IGF1) , right before bed would be a good time to dose because it mimics the natural pattern (GH pulse)
DickySmalls
Member
@ProfessorX
I thought exogenous administration of HGH will suppress it so much that you won't get a pulse @ night if you dose it early AM. I could have sworn I read something like that which Dr Jim posted.
I thought exogenous administration of HGH will suppress it so much that you won't get a pulse @ night if you dose it early AM. I could have sworn I read something like that which Dr Jim posted.
Early a.m. dosing would fall between the nightly natural pulse (REM) and the daily natural pulse.....dosing at the least disruptive time of natural GH release
Exogenous GH shuts down natural GH release temporarily (according to my HRT clinic)
Exogenous GH shuts down natural GH release temporarily (according to my HRT clinic)
DickySmalls
Member
I think this was the one:
When is the best time to inject hgh?
Edit: And this:
when do you take you hgh ?
This question has been asked on several occasions previously which compels me to believe it arises from the belief the exogenous administration of GH does not alter GHRF levels, when it most certainly does!
I'm no medical person but I searched GHRF and found the Wiki: Growth hormone–releasing hormone - Wikipedia
It says "GHRH stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary." so according to Jim, assuming I understood correctly, taking HGH lowers GHRF levels so there won't be a pulse @ night.
If I've read that correctly, I think he is in agreement with the early a.m. dose.
He also mentioned negative feedback loop
Someone with a normal pituitary function lacking a deficiency, taking your GH right before bed is going to end up creating a negative feedback loop, robbing you of your body’s own nightly pulse of GH
He also mentioned negative feedback loop
Someone with a normal pituitary function lacking a deficiency, taking your GH right before bed is going to end up creating a negative feedback loop, robbing you of your body’s own nightly pulse of GH
One injection of HGH will disrupt natural production of hgh up to 24hrs I believe is well known. So all the bullshit about least disruptive time are all well.... broscience.
Early morning you will be probably a zombie half of the day. I never seen a difference doing twice a day or just one at bed. Especially if you have to do it for 6-7 or more months... it will get old fast. You all really over complicate stuff a lot.
Shoot it in one go and job's done.
Do EOD injection if you want a natural pulse.
Early morning you will be probably a zombie half of the day. I never seen a difference doing twice a day or just one at bed. Especially if you have to do it for 6-7 or more months... it will get old fast. You all really over complicate stuff a lot.
Shoot it in one go and job's done.
Do EOD injection if you want a natural pulse.
DickySmalls
Member
I wish an expert would come in here and chime in
BigAli
New Member
LOL
"Least disruptive timing" isn't BroScience
Example:
My IGF1 at 5IUs early a.m. was similar to someone using 2IUs 5 times (10 IUs) during the day
The 5X daily doses of 2IUs disrupted natural GH release
For me, one SubQ dose early morning elevated my IGF1 the best
Sometimes simplicity works the best.
DickySmalls
Member
You know what would be great. A website where all of this bro-science shit and misconceptions could be explained/debunked with scientific data to back it up. Like if someone right now linked to a research paper that had data suggesting that an HGH injection every 24 hours suppressed the natural production, that would be tits.
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