Testosterone Synthesis

[Night_Owl]

Sharing my research on Testosterone Synthesis.

Testosterone Cypionate:

Testosterone Enanthate:

 

[Night_Owl]

Method for the preparation of testosterone and its esters

Patent: US2742485A

 

[Night_Owl]

The history of discovery, synthesis and development of testosterone for clinical use.

PMID: 30959485

ENDOCRINE HISTORY: The history of discovery, synthesis and development of testosterone for clinical use in: European Journal of Endocrinology Volume 180 Issue 6 (2019)

 

[bambam333]

The history of discovery, synthesis and development of testosterone for clinical use.

PMID: 30959485

ENDOCRINE HISTORY: The history of discovery, synthesis and development of testosterone for clinical use in: European Journal of Endocrinology Volume 180 Issue 6 (2019)

You workin on being the new raw supplier. I’m in send me list when your ready

 

[BroScientist]

Synthesis is often easy. Removing the by-products of synthesis, and purifying the product is the hard part.

 

[Night_Owl]

@bambam333 will do, we never know where life will take us I guess, haha.

 

[Night_Owl]

I think I'm going to pay to have this patent translated by someone:

https://patentimages.storage.googleapis.com/4d/6f/a7/2a3a7ecb3cc7fa/CN106146592A.pdf

Unless someone will do it for free? Either way, this is a very popular patent and I think we need it.

A kind of synthesis testosterone method
CN106146592A

The invention provides a kind of synthesis testosterone method, including: step 1, androstenedione is dissolved in the mixed solvent system of 5 15 times (weight ratios), is cooled to less than 10 DEG C；Step 2, is dissolved in potassium borohydride in the pure water of 8 15 times (weight ratios)；Step 3, solution step 2 configured is added in feed liquid that 5 15 times of (weight ratio) steps 1 obtain, 5 DEG C to 10 DEG C；Step 4, reacts under the conditions of 5 DEG C to 10 DEG C to androstenedione reaction completely, adds the glacial acetic acid of weight is described potassium borohydride 15 40%, to destroy the potassium borohydride of excess, then decompression and solvent recovery, add water, filter, obtain crude product；Step 5, crude product obtains testosterone fine work through ethyl alcohol recrystallization.

 

[Night_Owl]

Sciencemadness Discussion Board - testosterone from cholesterol - Powered by XMB 1.9.11

 

[Night_Owl]

A New Synthesis of Testosterone.
doi:10.1246/bcsj.22.1

 

[Night_Owl]

@BroScientist check it out:

JPS562999A - Purification of testosterone enanthate - Google Patents

 

[Night_Owl]

US2109400A
Esters of testosterone and process of making same

 

[Night_Owl]

Going down the rabbit hole....

https://archive.is/bFsbH (Turn progesterone or deoxycorticosterone into testosterone? : TheeHive)

WO2011000693A1 - Process for the preparation of testosterone - Google Patents

Sciencemadness Discussion Board - Adding esters to compounds (propionate, enanthate, cypionate, etc) - Powered by XMB 1.9.11

Sciencemadness Discussion Board - Synth Difficulty- Proprionic anhydride. - Powered by XMB 1.9.11 (last comment about testosterone)

 

[Night_Owl]

Cypionic acid - Wikipedia

youtube.com/watch?v=xheOq0XZ-so

 

[Night_Owl]

@WolfGain I'm tagging you because I found your thread to be similar, thought you might enjoy this one too.

Synthesis of testosterone from DHEA via 5-androstene-3,17-diol

Process of Making Testosterone

Here's the detailed process on how anabolic steroids are made in chemical factories

@hjalmar are you still on this forum?

 

[Physique Demon]

@iamnightowl you seem like a whacky scientist.

 

[Night_Owl]

@Physique Demon I wish, I'm just trying to figure this thing out.

 

[Night_Owl]

@master.on posted this gem in 2017:

https://gpcb.gov.in/pdf/LA_CHANDRA_PAL1_EIA.PDF

Page 56 ^

Thanks @master.on you might find this thread interesting too. Although 3 years later...

 

[Night_Owl]

 

[Night_Owl]

Seems like the Indians are making it by starting with Androstenedione.

 

[BroScientist]

You can't buy Androstenedione in the US anymore without the proper license. You would probably have to start with DHEA.

Androstenedione Supplement Review - Know The Pros & Cons