I'll have to weigh in on this one. People get used to whatever area they live in, so there will always be something uncomfortable about other parts of the country. I've been in most of the US, and here's my summary so far:
Southeast except for Florida: Lots of sprawl, office parks, malls, golf courses. Big cities are becoming generic, especially ATL. Chicks can be gorgeous; UNC Chapel Hill is a dangerous place for me when I'm on a gram of suspension a week. People are very nice, extremely well mannered. For the bro from Jackson, MS, this place has the hottest collection of chicks I've seen. I don't know why there's so much hot pussy concentration there. The gyms are absolutely terrible. Locker rooms are nasty and insulting for the price. No bumper plates.
Florida: Panhandle is beautiful, best beaches in the US, but no reason to live there. Love Miami. The place to be if I were rich. Anywhere else in Florida I don't care for. The people aren't that friendly.
DC: Love it. Very comfortable, especially in Old Town.
Northeast: Have lots of friends from Conn and Ma. People seem quirky, but it's ok. Areas outside of Boston are nice. Love NYC; great people generally, but I'd have no desire to live there. Strong Island people are good folks.
Midwest/Chicago: Damn reliable people, hard workers, good gyms, good place to do business. Some of the nicest people I've met. I'd live in Chicago if I could stand the cold. Don't throw 'em in the same group with Yankees, or you might get you ass kicked. The Minnesota people I've met are good folk, salt of the earth, trustworthy. Minn is just way too cold though.
Texas/Okie: Good friends there, but I wouldn't care to live there at all. Some parts of Houston are pretty nice, but except for Bob's Chop Shop by Love Field, Dallas is sucky. Best Hertz facility in the country though at DFW. Some of the chicks are hot.
Southwest: I'll live there someday. Beautiful area. People are ok, but seem indifferent and not as rooted as anywhere in the east.
California: Absolutely rich and beautiful state, and is a good example of why the US has the richest land in the world. From San Diego up, I've never had a bad time in Cali, and there's places that I might want to live, but not really. Seems like everything should be torn down and they should try again to get it right.