Tirzepatide: Beyond Appetite Control

[pizzathehutt]

...and really all the other GLP-1 and multi-receptor agonists. For simplicity, I'm focusing on what I have personal experience with, Tirzepatide.

Many get hung up on the appetite suppression benefits of these agonists -- for good and bad.

I believe the narrative needs a shift. In my mind, Tirzepatide’s (and the others) weight loss effects extend beyond simple appetite suppression.

From my understand, these agonists improves insulin sensitivity, increases energy expenditure, enhances lipid metabolism, positively alters gut hormone levels, reduces fat accumulation, possesses anti-inflammatory properties, and improves glycemic control.

All of these combined mechanisms contribute to its overall effectiveness in promoting weight loss and improving metabolic health.

Yes, appetite suppression and caloric deficits is the main player but there's so much more.

Next, I'd like to tie together current public research alongside the wealth of reports across various places to really hone in a solid, data backed, message.

Why? I have friends and colleagues that reject these peptides. Smart folks that have unfortunately accepted narratives that have made even considering usage socially taboo. Folks that could really benefit from them. I'd like them to be around.

 

[Trenbolonetax]

Do you drink coffee? I’m starting out on tirz and I’m having the weirdest side effects. I feel like an anxious feeling and dizziness and I’m not sure if it’s related to my caffeine intake or I’m just getting used to it. I’ve decreased my dose but the side effects are quite miserable.

The GLP1s can cause body to absorb higher % of medication / other drugs as they slow digestion. Can also cause delayed effect from medication / other drugs due to this slowing.

I never got any type of anxiety / dizziness from Tirz or Reta. However, I did get a bit of what I will call "fatigue / lethargy" from Tirz, especially after larger meals, due to the delayed gastric emptying I think.

 

[DugPrime]

I don't want to open a whole post for this, so I'll ask here.

I've hit the maximum dosage of tirzepatide and stopped feeling any appetite suppression. I took a 6-week break, but it didn't help—tirzepatide no longer seems effective for managing my BED.

Is there anything I can do, aside from spending hundreds more on other compounds?

 

[Trenbolonetax]

I don't want to open a whole post for this, so I'll ask here.

I've hit the maximum dosage of tirzepatide and stopped feeling any appetite suppression. I took a 6-week break, but it didn't help—tirzepatide no longer seems effective for managing my BED.

Is there anything I can do, aside from spending hundreds more on other compounds?

There is a 20mg Tirzepatide dose in trial currently. You could increase to that. Or more, but then you're in uncharted territory.

For the broscience answer, you could add a small amount of sema to your existing max tirzepatide dose. Incredibly cheap, and should be pretty helpful.

Or you could explore Cagrilintide (sp) to use alongside Tirz.

 

[RekTest]

I took a 6-week break,

Should have listened to Ghoul,

Also its theorized UGL to Pharma isnt a 1 to 1, Pharma being stronger, thus with ugl you could (I have) go over the pharma dosage protocol.

 

[DugPrime]

Should have listened to Ghoul,

About what?

Also its theorized UGL to Pharma isnt a 1 to 1, Pharma being stronger, thus with ugl you could (I have) go over the pharma dosage protocol.

Yeah this is definitely what I will do, and start my 20mg dose tomorrow.

There is a 20mg Tirzepatide dose in trial currently. You could increase to that. Or more, but then you're in uncharted territory.

For the broscience answer, you could add a small amount of sema to your existing max tirzepatide dose. Incredibly cheap, and should be pretty helpful.

Or you could explore Cagrilintide (sp) to use alongside Tirz.

I don’t want to spend more hundreds on other drugs, but I’ll definitely titrate up to 20mg. Hopefully, after the 3-month bulk, my tolerance will reset when I get back on tirz.

 

[iris]

About what?

About stopping and then restarting, high potential for loss of effectiveness

 

[DugPrime]

About stopping and then restarting, high potential for loss of effectiveness

Oh I see, unfortunately it wasn't my choice, I had no stock left and was waiting for the next GB.

 

[IronMetal_2]

I don't want to open a whole post for this, so I'll ask here.

I've hit the maximum dosage of tirzepatide and stopped feeling any appetite suppression. I took a 6-week break, but it didn't help—tirzepatide no longer seems effective for managing my BED.

Is there anything I can do, aside from spending hundreds more on other compounds?

Did you regain weight though while on tirzepatide? Again, I think you misunderstand how these drugs work. They are also meant to be taken long-term, there is no tolerance. Stopping and Starting again will increase the chances of you becoming a non-responder, that's been seen by medical professionals in real life settings.

They sort of reset your "Set-Point". You are not going to lose weight non stop on these drugs, that's not how they work.

@Ghoul is the best to give you a good explanation.

They also don't cure BED.

 

[nullandvoid]

Oh I see, unfortunately it wasn't my choice, I had no stock left and was waiting for the next GB.

Dug, if you fail to plan, you plan to fail. Get on it.

 

[IronMetal_2]

I might switch from tirzepatide back to semaglutide for a couple weeks/months before going back on tirzepatide.

Anecdotaly we know that it is not a good idea to stop and restart glp1-r agonists because of drug Tachyphylaxis. Anyone has any idea on switching with regards to this matter?