Tirzepatide: Beyond Appetite Control

[pizzathehutt]

...and really all the other GLP-1 and multi-receptor agonists. For simplicity, I'm focusing on what I have personal experience with, Tirzepatide.

Many get hung up on the appetite suppression benefits of these agonists -- for good and bad.

I believe the narrative needs a shift. In my mind, Tirzepatide’s (and the others) weight loss effects extend beyond simple appetite suppression.

From my understand, these agonists improves insulin sensitivity, increases energy expenditure, enhances lipid metabolism, positively alters gut hormone levels, reduces fat accumulation, possesses anti-inflammatory properties, and improves glycemic control.

All of these combined mechanisms contribute to its overall effectiveness in promoting weight loss and improving metabolic health.

Yes, appetite suppression and caloric deficits is the main player but there's so much more.

Next, I'd like to tie together current public research alongside the wealth of reports across various places to really hone in a solid, data backed, message.

Why? I have friends and colleagues that reject these peptides. Smart folks that have unfortunately accepted narratives that have made even considering usage socially taboo. Folks that could really benefit from them. I'd like them to be around.

 

[Trenbolonetax]

Do you drink coffee? I’m starting out on tirz and I’m having the weirdest side effects. I feel like an anxious feeling and dizziness and I’m not sure if it’s related to my caffeine intake or I’m just getting used to it. I’ve decreased my dose but the side effects are quite miserable.

The GLP1s can cause body to absorb higher % of medication / other drugs as they slow digestion. Can also cause delayed effect from medication / other drugs due to this slowing.

I never got any type of anxiety / dizziness from Tirz or Reta. However, I did get a bit of what I will call "fatigue / lethargy" from Tirz, especially after larger meals, due to the delayed gastric emptying I think.

 

[DugPrime]

I don't want to open a whole post for this, so I'll ask here.

I've hit the maximum dosage of tirzepatide and stopped feeling any appetite suppression. I took a 6-week break, but it didn't help—tirzepatide no longer seems effective for managing my BED.

Is there anything I can do, aside from spending hundreds more on other compounds?

 

[Trenbolonetax]

I don't want to open a whole post for this, so I'll ask here.

I've hit the maximum dosage of tirzepatide and stopped feeling any appetite suppression. I took a 6-week break, but it didn't help—tirzepatide no longer seems effective for managing my BED.

Is there anything I can do, aside from spending hundreds more on other compounds?

There is a 20mg Tirzepatide dose in trial currently. You could increase to that. Or more, but then you're in uncharted territory.

For the broscience answer, you could add a small amount of sema to your existing max tirzepatide dose. Incredibly cheap, and should be pretty helpful.

Or you could explore Cagrilintide (sp) to use alongside Tirz.

 

[RekTest]

I took a 6-week break,

Should have listened to Ghoul,

Also its theorized UGL to Pharma isnt a 1 to 1, Pharma being stronger, thus with ugl you could (I have) go over the pharma dosage protocol.