MESO-Rx Exclusive Trenbolone facts - series on unique characteristics of different steroids

[Deleted member 59947]

Basically yes. There's no question that skeletal muscle hyperplasia occurs when combining AAS & resistance training (and even clen, not to mind GH, increase it). The debate was always whether it occurs without drugs... it does.

Skeletal muscle hyperplasia ALSO happens with AAS and NO resistance training.

 

[Type-IIx]

Skeletal muscle hyperplasia ALSO happens with AAS and NO resistance training.

If you say so hotshot

 

[trtbuilder]

Skeletal muscle hyperplasia ALSO happens with AAS and NO resistance training.

Youre so desperate for attention. Hilarious.

 

[Ateam2023]

and yet people keep "entertaining " this guy by verbal jousting with him its pretty funny how this guy gets under everones skin , but hey lets keep feeding his ego lol

 

[Excel.exe]

how this guy gets under everones skin

At least he gets that done transdermally and it works!

 

[Type-IIx]

At least he gets that done transdermally and it works!

I got it. And I agree.

 

[ksm2]

@Type-IIx What is your opinion on this old meso article by Bill Roberts?

Does Trenbolone Have Progestagenic Activity or Increase Prolactin?

Q: “Is trenbolone progestagenic? Or does trenbolone increase prolactin? A friend did a cycle of 500 mg/week testosterone plus 500 mg/week trenbolone enanthate and got gyno, when previously he’d done just the testosterone and did fine. This has me concerned about trenbolone.”

A: Trenbolone has near zero progestational activity, as found both in veterinary science and in cell studies. Its activation of the progesterone receptor (PR) is about 100 times weaker than that of progesterone itself. Trenbolone levels achieved during steroid cycles cannot activate the PR to even a small fraction as much as is caused by natural progesterone levels.

At least one veterinary study also found trenbolone to not increase prolactin measurably, despite depressing thyroid levels.

In your friend’s cycle, prolactin may well have increased. Where an aromatizing steroid is used and estrogen levels are not controlled with an anti-aromatase, estradiol levels typically rise. This often but not always causes an increase in prolactin, and sometimes a large increase.

It’s impossible to determine why gynecomastia developed for your friend this time but not on the previous occasion, particularly as no blood test was performed. Uncontrolled increase in estrogen due would certainly have contributed. Elevated prolactin caused by increased estrogen could be a contributor.

Does Trenbolone Have Progestagenic Activity or Increase Prolactin?

Q: "Is trenbolone progestagenic? Or does trenbolone increase prolactin? A friend did a cycle of 500 mg/week testosterone plus 500 mg/week trenbolone

thinksteroids.com

Looks like chatgpt also agrees on this. Weird, since literally everyone is warning about tren prolactin sides.

Is it true that trenbolone doesn't increase prolcatin?

Based on the available evidence, it appears that trenbolone does not directly increase prolactin levels, contrary to common belief:

A study on sheep found that plasma prolactin was unaltered by trenbolone acetate treatment, either alone or in combination with estradiol

Human trials for anemia treatment showed that nandrolone (which is structurally similar to trenbolone) actually reduced prolactin levels compared to baseline, while testosterone slightly increased it

Research indicates that only aromatizable androgens (those that can convert to estrogen) seem to stimulate prolactin secretion. Trenbolone is not aromatizable, so it should not directly increase prolactin

The common belief that trenbolone increases prolactin may stem from the fact that it is often used alongside high doses of testosterone, which can aromatize to estrogen and potentially increase prolactin

Elevated prolactin levels observed during trenbolone cycles are likely due to the concurrent use of aromatizable testosterone rather than trenbolone itself

Some studies suggest that controlling estrogen levels through proper aromatase inhibitor use may be key to managing prolactin levels during steroid cycles

In conclusion, the evidence suggests that trenbolone itself does not increase prolactin levels. The perception that it does may be due to its common use alongside high doses of testosterone, which can increase estrogen and subsequently prolactin. Proper management of estrogen levels appears to be crucial for controlling prolactin during steroid cycles involving trenbolone.

 

[Type-IIx]

@Type-IIx What is your opinion on this old meso article by Bill Roberts?

Does Trenbolone Have Progestagenic Activity or Increase Prolactin?

Q: "Is trenbolone progestagenic? Or does trenbolone increase prolactin? A friend did a cycle of 500 mg/week testosterone plus 500 mg/week trenbolone

thinksteroids.com

Looks like chatgpt also agrees on this. Weird, since literally everyone is warning about tren prolactin sides.

Trenbolone decreases prolactin but has progestagenic effects. Specifically, trenbolone activates the progesterone receptor with 35% the potency of progesterone.

See Article on distinguishing progestins, prolactin, and progestagenic androgens (e.g., Tren, MENT, Deca) & SERM vs. AI logic [by Type-IIx]

 

[Deleted member 59947]

@Type-IIx What is your opinion on this old meso article by Bill Roberts?

Does Trenbolone Have Progestagenic Activity or Increase Prolactin?

Q: "Is trenbolone progestagenic? Or does trenbolone increase prolactin? A friend did a cycle of 500 mg/week testosterone plus 500 mg/week trenbolone

thinksteroids.com

Looks like chatgpt also agrees on this. Weird, since literally everyone is warning about tren prolactin sides.

Bill Robert is the real man

 

[ZyzzReincarnate]

Oh, God. I have to say I love this image (below). Say what you will about AI – and definitely count me among the detractors at this moment but hedging my bets – this is fucking gold!

What a powerful image

 

[HKOX]

These articles are really helpful. Thank you!

 

[Type-IIx]

These articles are really helpful. Thank you!

Very welcome! Glad you like

 

[BuildABro]

This was a fantastic read. Can't believe it took me until now to take the time to check it out. I have always found it frustrating that we do not have more clinical data to go on regarding Trenbolone. By this I mean Parabolan (Trenbolone Hexahydrobenzylcarbonate) was an approved medication with active prescriptions in France for 17 years, from 1980-1997.

Unless the French were just uniquely loose with their standards for medications in those days, this would suggest that human clinical trials and associated data exists for Trenbolone. So where is this data today? Being able to review this information would be supremely insightful.

 

[Grey Spartan]

Number two takes up too much space, is not very aerodynamic, mansplains all the time, and probably breaks his pants every time he bends down.

LMAO!

 

[Type-IIx]

This was a fantastic read. Can't believe it took me until now to take the time to check it out. I have always found it frustrating that we do not have more clinical data to go on regarding Trenbolone. By this I mean Parabolan (Trenbolone Hexahydrobenzylcarbonate) was an approved medication with active prescriptions in France for 17 years, from 1980-1997.

Unless the French were just uniquely loose with their standards for medications in those days, this would suggest that human clinical trials and associated data exists for Trenbolone. So where is this data today? Being able to review this information would be supremely insightful.

There’s no English-language human data. There might be French, you’d have to probably touch down in France and trace it down physically. Clinical Trials are a modern process of drug testing followed by countries that include France today, but that doesn’t imply they’ve always done this; or for every medication in their history.

I wouldn’t be surprised if a French reader was able to find something.

 

[BuildABro]

There’s no English-language human data. There might be French, you’d have to probably touch down in France and trace it down physically. Clinical Trials are a modern process of drug testing followed by countries that include France today, but that doesn’t imply they’ve always done this; or for every medication in their history.

I wouldn’t be surprised if a French reader was able to find something.

I had French in 7th grade, and bonjour is about I can recall. Surely there has to be someone on the board that can speak French, so maybe we can eventually track down some info.

Even if they did not conduct trials back then, surely they had to have some sort of research justification for bringing Parabolan to market.

 

[Type-IIx]

I had French in 7th grade, and bonjour is about I can recall. Surely there has to be someone on the board that can speak French, so maybe we can eventually track down some info.

Even if they did not conduct trials back then, surely they had to have some sort of research justification for bringing Parabolan to market.

Yes, they must

 

[BuildABro]

Yes, they must

I did quite a bit of digging on the subject before I ran my first cycle of Parabolan. The company that was manufacturing it back then was called Negma Laboratories. It was used medically for various muscle wasting conditions. Negma continued to manufacture the drug in ampules up until 1997 when it was discontinued and pulled from the market.

Unfortunately Negma was sold to an Indian pharma conglomerate in 2007 and all traces of their content on the internet basically ceased to exist. I can't find anything via wayback machine or other archive sites. And that is where the story and the rabbit hole ends unfortunately. Maybe eventually someone more resourceful or linguistically gifted will uncover more.

 

[iris]

I did quite a bit of digging on the subject before I ran my first cycle of Parabolan. The company that was manufacturing it back then was called Negma Laboratories. It was used medically for various muscle wasting conditions. Negma continued to manufacture the drug in ampules up until 1997 when it was discontinued and pulled from the market.

Unfortunately Negma was sold to an Indian pharma conglomerate in 2007 and all traces of their content on the internet basically ceased to exist. I can't find anything via wayback machine or other archive sites. And that is where the story and the rabbit hole ends unfortunately. Maybe eventually someone more resourceful or linguistically gifted will uncover more.

That's why Type-IIx wrote "you’d have to probably touch down in France and trace it down physically".

Isn't there a French Meso?

 

[BuildABro]

That's why Type-IIx wrote "you’d have to probably touch down in France and trace it down physically".

Isn't there a French Meso?

Meso field trip to Paris anyone?