Using Aromasin for Pct

I will let you know how it turns out.
What dosage do you use of aromasin? Do you get bad E sides?
I get really high E I was 175 last cycle on a 42 point scale at 7-8 weeks and had minor sides that nolva was covering but for my prostates sake etc I started running adex. I am under the understanding that it is not as harsh and more controllable that is why I chose it.

12.5 mg is all I've ever needed for Aromasin.. I don't get very bad E sides, I bloat on test but the Aromasin works very well for me.
 
I'm trying a little aromasin with PCT, but just a low dose, 3mg a day of pharma grade.
I'm going with the theory that since estrogen suppresses LH and FSH output that I should keep it on the low side but not crashed. I get real achey joints when estro gets low, so it's easy to know if I'm overdoing it.
 
I will try Aromasin for pct. I have ran it a little through my cycle. However my Letro kicked the sensitive nipples ass. The Letro makes me feel a bit crappy. I feel great on Aromasin.

MFL REP
 
are u takeing it ed eod or ?

I take Aromasin every day on cycle, the half life is around 21 hours..12.5mg ED is the sweet spot for me. I won't be using it for pct but I am very interested in everyone else's results. So keep us posted guys, labs would be great!!
 
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I take Aromasin every day on cycle, the half life is around 21 hours..12.5mg ED is the sweet spot for me. I won't be using it for pct but I am very interested in everyone else's results. So keep us posted guys, labs would be great!!

I meant to say 27 hours for the half life of Aromasin... I take it at the same time everyday....
 
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I meant to say 27 hours for the half life of Aromasin... I take it at the same time everyday....

I saw a study that stated that the half life was shorter in males, about 9 hours I think.


here is a copy paste from another site:
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Also, there have been some additional researches related to Aromasin in men in pharmacokinetics. The results of the research are the following:

24 hours after one 25mg dose, estrogen levels are reduced by 70-80%;

72 hours later estrogen levels are still 40% below the baseline;

120 hours after initial dose, estrogen levels return to baseline.

Additionally, the University of Florida conducted a study in healthy young men:

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males.

Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977

To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg Aromasin daily, orally, for 10 days with a 14 day washout period. Blood was withdrawn before and 24 hours after the last dose of each treatment period. A PK study was performed using a 25mg dose. Aromasin suppressed plasma estradiol comparably with either dose [25 mg, 38%; 50 mg, 32%], with a reciprocal increase in testosterone concentrations (60% and 56%; for both).

The following observations were made:

Plasma lipids and IGF-I concentrations were unaffected by treatment.
The PK properties of the 25-mg dose showed the highest concentrations 1 h after administration, indicating rapid absorption.
Maximal estradiol suppression of 62 ± 14% was observed at 12 h.
The drug was well tolerated.
The terminal half-life was 8.9 hours in the male subjects.
In conclusion, Aromasin (Exemestane) is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

References and Supporting Data:

A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.Br J Clinical Pharmacology. 2005 Mar, 59(3):355-64.

Eur. J. Cancer. 2000, May;36(8):976-82

The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 12 5951-5956Copyright © 2003 by The Endocrine Society

Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S

Anticancer Res. 2003 Jul-Aug;23(4):3485

J Clin Endocrinol Metab. 2003 Dec;88(12):5951-6.
 
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I saw a study that stated that the half life was shorter in males, about 9 hours I think.


here is a copy paste from another site:
\\
Also, there have been some additional researches related to Aromasin in men in pharmacokinetics. The results of the research are the following:

24 hours after one 25mg dose, estrogen levels are reduced by 70-80%;

72 hours later estrogen levels are still 40% below the baseline;

120 hours after initial dose, estrogen levels return to baseline.

Additionally, the University of Florida conducted a study in healthy young men:

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males.

Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977

To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg Aromasin daily, orally, for 10 days with a 14 day washout period. Blood was withdrawn before and 24 hours after the last dose of each treatment period. A PK study was performed using a 25mg dose. Aromasin suppressed plasma estradiol comparably with either dose [25 mg, 38%; 50 mg, 32%], with a reciprocal increase in testosterone concentrations (60% and 56%; for both).

The following observations were made:

Plasma lipids and IGF-I concentrations were unaffected by treatment.
The PK properties of the 25-mg dose showed the highest concentrations 1 h after administration, indicating rapid absorption.
Maximal estradiol suppression of 62 ± 14% was observed at 12 h.
The drug was well tolerated.
The terminal half-life was 8.9 hours in the male subjects.
In conclusion, Aromasin (Exemestane) is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

References and Supporting Data:

A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.Br J Clinical Pharmacology. 2005 Mar, 59(3):355-64.

Eur. J. Cancer. 2000, May;36(8):976-82

The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 12 5951-5956Copyright © 2003 by The Endocrine Society

Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S

Anticancer Res. 2003 Jul-Aug;23(4):3485

J Clin Endocrinol Metab. 2003 Dec;88(12):5951-6.

Interesting.... I will still only use aromasin once a day however..
 
another part of that study that is interesting is the time it takes to return to normal estrogen after knocking it down. It takes way longer than the half life of the aromasin to generate more aromatase enzymes and convert more test to estro.

I'll stick with once a day also.

I'm going to drop my dose down from 3mg a day to 2 mg a day. Joints felt dry and achy today, I'm guessing me estro is too low.
 
another part of that study that is interesting is the time it takes to return to normal estrogen after knocking it down. It takes way longer than the half life of the aromasin to generate more aromatase enzymes and convert more test to estro.

I'll stick with once a day also.

I'm going to drop my dose down from 3mg a day to 2 mg a day. Joints felt dry and achy today, I'm guessing me estro is too low.

You are using it for PCT, is that correct? I figured that is why your using such a low dose...
 
You are using it for PCT, is that correct? I figured that is why your using such a low dose...
Yep, using it for PCT. I have pharma grade aromasin and it works really well.
On cycle I only needed to run 4mg a day.
 
FSH- 8.8
LH - 8.6
E2- 60
Test 784

Bloods from the middle of week 4 pct. This was my 3 serm pct, plus a small dose of aromasin at 2mg a day. I skipped aromasin for a couple days before these bloods were taken, had some achey joints.

probably could have used a tad more aromasin.
 
FSH- 8.8
LH - 8.6
E2- 60
Test 784

Bloods from the middle of week 4 pct. This was my 3 serm pct, plus a small dose of aromasin at 2mg a day. I skipped aromasin for a couple days before these bloods were taken, had some achey joints.

probably could have used a tad more aromasin.

Pretty damn good for PCT bro... But yah that is a small dose.... I wonder if the aromasin is contributing to your TT level...How long was your bridge period and did u use HCG?
 
i love aromasin have you looked into a sarm like ostarine for pct its great and if u can run insulin ed pct u will retain gains ;)
 
i love aromasin have you looked into a sarm like ostarine for pct its great and if u can run insulin ed pct u will retain gains ;)

Sure you will if that next cycle begging in 2-4 weeks.

Your using some very atypical PCT meds none (except the AI) of which are physiologically based. Consequently recommending these type of alterations should be supported by more than just "your experience".
 
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