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WADA issues alert on GW501516 aka GW1516, Endurobol

Millard

Millard

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WADA made unprecedented warning against a PED - GW1516 - because "side effect of this compound is so serious..." and toxic in clinical studies.

But they didn't identify the "toxic" and "serious" side effect. The link they provided didn't provide any clarification on this as far as I can tell.

Is this simply scare tactics? Or has some new information come to light?

WADA issues alert on GW501516
March 21, 2013

It has come to WADA’s attention that the black market substance GW501516 is being sold to and used by some athletes.

The side effect of this chemical compound is so serious that WADA is taking the rare step of warning “cheats” to ensure that there is complete awareness of the possible health risks to athletes who succumb to the temptation of using GW501516 for performance enhancement.

GW501516 was a developmental drug that was withdrawn from research by the pharmaceutical company and terminated when serious toxicities were discovered in http://www.toxicology.org/AI/Pub/Tox/2009Tox.pdf (pre-clinical studies).

Clinical approval has not, and will not be given for this substance.

However, GW501516 has been available for some months on the black market, through the Internet and elsewhere. Anti-Doping authorities have already seen its use by athletes, as there are a number of positive cases.

Please pass this information on to your athletes as soon as possible.
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http://playtrue.wada-ama.org/news/wada-issues-alert-on-gw501516/
 
Dont get me wrong I think WADA and USADA are both a freaking joke with obvious agendas but I wonder if they are referring to the issues of increase risk of polyp development. Interestingly enough a simple cox2 inhibitor ( like tribulus) virtually eliminates this side effect.

-Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN
Department of Medicine, The Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6838, USA. PMID 14758356

-Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK Department of Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, 120-750, Seoul, South Korea Journal of ethnopharmacology 83:1-2 2002 Nov pg 153-9 PMID 12413723

What do you think Millard?
 
Last edited:
Jimmyinkedup said:
Dont get me wrong I think WADA and USADA are both a freaking joke with obvious agendas but I wonder if they are referring to the issues of increase risk of polyp development. Interestingly enough a simple cox2 inhibitor ( like tribulus) virtually eliminates this side effect.

-Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN
Department of Medicine, The Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6838, USA. PMID 14758356

-Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK Department of Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, 120-750, Seoul, South Korea Journal of ethnopharmacology 83:1-2 2002 Nov pg 153-9 PMID 12413723

What do you think Millard?
Click to expand...

Very possibly. The urgency of the alert suggests it's something that may be new. But most likely not. The fact that they didn't bother to specify what side effect they were talking about suggests it's more of a scare tactic i.e. "it's so dangerous we can't even tell you about it - just trust us"
 
Millard Baker said:
Very possibly. The urgency of the alert suggests it's something that may be new. But most likely not. The fact that they didn't bother to specify what side effect they were talking about suggests it's more of a scare tactic i.e. "it's so dangerous we can't even tell you about it - just trust us"
Click to expand...

Oh yes I agree its definitely a propaganda driven move for sure but when push comes to shove maybe that is what they are sitting on..which isnt near the "danger":they present it to be - Then again what is with them?:confused:
 
Also, it could be another way WADA is saying GW1615 works too well, is seeing widespread use in a variety of sports, it's undetectable and therefore WADA is powerless to do anything about it - except use scare tactics as a deterrent.

Not trying to minimize the risks - and always interested in learning about new PED-related risks - but can't really trust WADA when it comes to PED education.
 
IMO, there is probably some truth and hysteria. Since the drug is not approved this means the manufacturing process is NOT for human use. So there might be any number of factors. As far as believing another drug can 100% prevent side effects, NOT. In the AAS world risks are always taken without the known benefits.
 
Jimmyinkedup said:
Very true...
Click to expand...

I agree also! I think most people with perceive many of the "newer" PEDs are safer than AAS due to the overwhelming negative stigma associated with AAS. Personally, I feel quite comfortable with the body of science on AAS spanning 50 years. It would be nice to get past the stigma and objectively evaluate risks on new PEDs - much more data is obviously needed. Fortunately or unfortunately, their will be no shortage of anecdotal trial and error by athlete lab rats to inform the direction the research takes.
 
Just about every substance that provides tangable positive benefits does so at the expense of compromising health in other ways. It would be nieve to thing GW1516 would be any different.

With that said, the fact that they're not willing to share their 'findings' leads me to believe that thier claims are vastly embellished. I'm currently taking 30mg ED at the moment and have no reservations about continuing my use.
 
Mike Oxbig said:
Just about every substance that provides tangable positive benefits does so at the expense of compromising health in other ways. It would be nieve to thing GW1516 would be any different.

With that said, the fact that they're not willing to share their 'findings' leads me to believe that thier claims are vastly embellished. I'm currently taking 30mg ED at the moment and have no reservations about continuing my use.
Click to expand...

If you did a log I would be really interested...I don't wanna hijack this thread, but maybe make a new one...or PM me the results you're experiencing.
 
Stretch said:
If you did a log I would be really interested...I don't wanna hijack this thread, but maybe make a new one...or PM me the results you're experiencing.
Click to expand...
I'm in the middle of a tren cycle at the moment, so crediting any effects to GW1516 would be next to impossible. I'll probably start a log when I go off cycle.
 
This is what newscientist.com says WADA was referring to when it warned of "serious" side effects:

The drug, called GW501516, was originally developed by pharmaceutical company GlaxoSmithKline (GSK) to stimulate muscles to burn fats instead of sugars, in order to raise levels of "good" cholesterol. But the company abandoned further development in 2006 after tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb. "GSK does not manufacture it or authorise its sale," says a company spokesman.
Click to expand...

I'd like to see the primary source for this data. Or statement from GSK.
 
Researcher said:
Not sure if the post went into twilight zone...sorry if double posting...

More critique on WADA announcement on:
https://theconversation.edu.au/anti...cheats-on-the-health-risks-of-endurobol-12997
Click to expand...

In this article, Benjamin Koh reviewed GSK research trial reports and didn't find documentation of serious side effects. He contacted GSK for more information. I wonder if he received a reply?

GSK undertook two phase I and one phase II clinical trials for GW501516.

A review of the reports for these shows one phase I clinical trial was terminated – but no reason is provided as to why. The other two trials were listed by GSK as completed...

A phase IV clinical study was completed in Australia in 2008...

No adverse events were reported by the authors for the phase IV trials. The authors also cited two earlier clinical studies that showed no significant adverse effect of the drug, including liver or muscle responses in participants treated with GW501516.
Click to expand...

https://theconversation.com/anti-doping-agency-warns-cheats-on-the-health-risks-of-endurobol-12997
 
I'm sorry guys, i'm as disappointed as anyone. I was ready to get some gw1516 but...
Check it here. http://www.toxicology.org/AI/Pub/Tox/2009Tox.pdf
It says some cancers appeared at high dosages, but some other appreared at all dosages...
these are all from 2009.
i don't think wada did this for the obvious reasons but because they didn't know anything till now. i can't find a single updated log of gw1516 and maybe cancers appeared after long exposure to the drug...it says the study lasted 104 weeks...
 
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