tileguy123
New Member
Fuck that LS there making your feet and hands look fat, send em this way.. you know a brother could use that about now
Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
damn lightspan beat me to it! Vial transfer fucked up karls gh! for all the fucking retards asking if the gh is good to go- right now it probably is because karl is selling pharm gh he is rebottling as his own. get it while the getting is good. IIf, in fact he is actually producing anything for down the line it will be shit eventually because he is not monitoring the bacteria that is cultivating the gh and is also not making sure the sequencing of the gh is correct.That is an accurate summary.
Ah, I had forgotten this. There was some handwavey "oxidizing excipient" explanation for the site injection pain. I've worked in the formulation space, that is a complete and utter bullshit explanation. Karl, what was this excipient that was so susceptible to oxidation that you used?
If an excipient were that susceptible to oxidation, it would not be used in a formulation. Period. No drug approval agency would ever approve an excipient that is chemically unstable, and no excipient manufacturer sells that sort of crap, because there is no market for it. If the excipients are the issue, Karl and his team need to go back to clown college and take the "how to formulate rHGH and make balloon animals" class. Again. Oddly enough, even if the sheep fucking professor is a world class biotech guy, he would be fairly clueless about formulations, it's a different art altogether.
If the material at issue had been transferred from, say, a pharma vial or pen insert into a new vial, and then lyophilized again, it could explain the problems with the "puck" exploding during transit due to the presence of residual solvent, and could also explain the site injection pain Poor lyophilization after transfer using an incorrectly prepared buffer (too acidic or basic) is a reasonable explanation for why the pucks "blew up" and there was site injection pain.
But let's give Karl the benefit of the doubt. Let's say it was an excipient issue. If so, these guys are pretty clueless and I wouldn't trust them to make me a balloon dog, much less an injectable formulation.
Order the shit. Don't order it. Again, I don't give a fuck, I have a stack of geno pens and I'll happily spend the kids' college fund to run it. The little bastards can go to community college, daddy needs his pharma gh.
That is an accurate summary.
Ah, I had forgotten this. There was some handwavey "oxidizing excipient" explanation for the site injection pain. I've worked in the formulation space, that is a complete and utter bullshit explanation. Karl, what was this excipient that was so susceptible to oxidation that you used?
If an excipient were that susceptible to oxidation, it would not be used in a formulation. Period. No drug approval agency would ever approve an excipient that is chemically unstable, and no excipient manufacturer sells that sort of crap, because there is no market for it. If the excipients are the issue, Karl and his team need to go back to clown college and take the "how to formulate rHGH and make balloon animals" class. Again. Oddly enough, even if the sheep fucking professor is a world class biotech guy, he would be fairly clueless about formulations, it's a different art altogether.
If the material at issue had been transferred from, say, a pharma vial or pen insert into a new vial, and then lyophilized again, it could explain the problems with the "puck" exploding during transit due to the presence of residual solvent, and could also explain the site injection pain Poor lyophilization after transfer using an incorrectly prepared buffer (too acidic or basic) is a reasonable explanation for why the pucks "blew up" and there was site injection pain.
But let's give Karl the benefit of the doubt. Let's say it was an excipient issue. If so, these guys are pretty clueless and I wouldn't trust them to make me a balloon dog, much less an injectable formulation.
Order the shit. Don't order it. Again, I don't give a fuck, I have a stack of geno pens and I'll happily spend the kids' college fund to run it. The little bastards can go to community college, daddy needs his pharma gh.
Just a side note. Red welts is reported on serostim by the fda. So it's totally impossible to happen. As does genotropin. They also list a ton of other side effects like rapid heart beat ,fever, so saying a medication never has side effects is not a real accurate statement. I'm not saying none if what u said is possible but a lot if what has been said is a pretty big accusation
Just a side note. Red welts is reported on serostim by the fda. So it's totally impossible to happen. As does genotropin. They also list a ton of other side effects like rapid heart beat ,fever, so saying a medication never has side effects is not a real accurate statement. I'm not saying none if what u said is possible but a lot if what has been said is a pretty big accusation
Surely that's not what someone said caused the injection site pain (want a list) an oxidizing excipient.
sciroxx-lab;1949364 said:...I'm quite confident it has to do with the hot weather on august.
for instance u may all see the reports from Viking55 and musles96 -
THERE WERE NO INJECTION ISSUES AT START ! AN EXCIPIENT THERE DETERIORATE PROBABLY IN THE HOT WEATHER.
sciroxx-lab;1949821 said:So far my team speculate that something deteriorated in the hot weather, when a reaction starts (say in the delivery in hot August) it may take even a couple of weeks till it may inflict the side effect, say for instance that 2% of an excipient deteriorated to another material, and it takes some time for it to react with oxygen to form something that the immune system react to which cause the injection issue, so first injections were fine, and now we have an issue with some of the customers that we'll solve.
BY NO MEANS SUCH SIDE EFFECT SHOULD HAPPEN, NO ONE IMPLIED IT'S ACCEPTABLE, WE'LL SOLVE THIS. I JUST STATED THAT THE PRODUCT LEFT OUR FACILITY IN PERFECT CONDITION, ALL FIRST TRIALS WERE FINE, AND ANY TEST WILL CONFIRM IT
sciroxx-lab;1949966 said:2. Let me make an inquiry about the pain. Say I may disolsolve it with lidocain for instance which my athlets overseas uses apparently and this will solve the pain issue .... so what u want now ?! I said let me make my investigation, the original Somatotropin from pirurity origin was used with lidocain
3. FFS - I proved u I take responsibility, I did, and will, let me do my things here, I do it properly.
---------------------------------------
We test now wide variety of possibilities which may cause pain, we test the stability of each of the excipients, and test everything on humans this weekend when have results on Rabbits.
this is an auto immune reaction to something there,
I'm sorry to repeat myself, but all first feedback were superb, check on this thread or anywhere, something inside deteriorated , there are not too many options, and I think we'll find it soon
Mt team are in constant touch with pharma companies to solve this.
I think we should have mess spec results in a couple of days from one who has the highest suspct in this product, so you're all in good hands
I keep getting high serum tests, wish someone would have done here IGF1 tests
sciroxx-lab;1950698 said:Yes boss, if you remember I asked the professor, and his reply is that it's caused by hot weather, and the GH is 100 intact as we tested it.
As the serum tests proved the GH is intact indeed !
But one of the excipients there (probably) reacted with something, it looks like "exploded",
First thing we did is to heat the excipients one by one and analyze them by a HPLC, well of of them are a bit harmed under heat, but ~98% stay intact, now the question is what is/are the rest of the 2%, this the HPLC couldn't exactly define, so we use some special kits that check different materials that may cause an allergy reaction, and keep testing it, this is what I flew for with my professor. Meanwhile we explore other excipients.
sciroxx-lab;1948243 said:We speculate that one excipient or so may be deteriorated in delivery.
sciroxx-lab;1952515 said:Generally we all know that the quality of the GH is superb, so just wait for the solution with the excipients
sciroxx-lab;1954603 said:New batch will be ready next weekend, we've started the production from scratch with a new proven tested formula,
sciroxx-lab;1960579 said:First the allergic reaction is 100% solved, as u all have witnessed there has been no injection issues at start, one of the excipients degraded in the hot weather of transportation which led to reaction with oxygen along time (even if 1% of the material is degraded such reaction may appear), which cause an allergic component to appear. The formulas is tested now for stability with 100% satisfied results, done and solved.
That is an accurate summary.
Ah, I had forgotten this. There was some handwavey "oxidizing excipient" explanation for the site injection pain. I've worked in the formulation space, that is a complete and utter bullshit explanation. Karl, what was this excipient that was so susceptible to oxidation that you used?
If an excipient were that susceptible to oxidation, it would not be used in a formulation. Period. No drug approval agency would ever approve an excipient that is chemically unstable, and no excipient manufacturer sells that sort of crap, because there is no market for it. If the excipients are the issue, Karl and his team need to go back to clown college and take the "how to formulate rHGH and make balloon animals" class. Again. Oddly enough, even if the sheep fucking professor is a world class biotech guy, he would be fairly clueless about formulations, it's a different art altogether.
If the material at issue had been transferred from, say, a pharma vial or pen insert into a new vial, and then lyophilized again, it could explain the problems with the "puck" exploding during transit due to the presence of residual solvent, and could also explain the site injection pain Poor lyophilization after transfer using an incorrectly prepared buffer (too acidic or basic) is a reasonable explanation for why the pucks "blew up" and there was site injection pain.
But let's give Karl the benefit of the doubt. Let's say it was an excipient issue. If so, these guys are pretty clueless and I wouldn't trust them to make me a balloon dog, much less an injectable formulation.
Order the shit. Don't order it. Again, I don't give a fuck, I have a stack of geno pens and I'll happily spend the kids' college fund to run it. The little bastards can go to community college, daddy needs his pharma gh.
ill go on the record and say I habe no idea, but just imagine the money to be made once he switches to generic dogshit he might pay $30 for 100iu that he is selling for $200 a pop minimum two per order... at multiple forums he is aggressively promoting at right now. ab, pm, olm, meso.... big fucking bucks on the back end.So if someone is transferring the GH into another bottle and relypholizing it like you suggested, what equipment would be necessary and how expensive is that equipment?