For the most part, possession and use of rHGH is not a crime in the US, at least no more than using unprescribed blood pressure meds would be. Possession with intent to distribute, and acts further up the chain from there is. (there are a couple of state level exceptions).
I can only speak regarding Tesamorelin, a well studied, FDA approved drug (Egrifta) with a long track record of safety.
For one. even without routine testing, it's generally safe for long term use. Acromegaly is not a risk, because you'll never exceed physiological levels of GH by enough to cause it. Similarly, new onset diabetes risk is very low. All natural pituitary feedback mechanisms are left intact. It can and has been used daily for decades with no "safety signals" of health harm. That's very appealing,
Tesa essentially mimics the "ideal conditions" that would trigger your body to max out endogenous growth hormone production. Perfect sleep, perfect nutrition, perfect health, and no stress,
ChatGPT didn't elaborate on why pulsatile release is beneficial. TLDR constant release like rHGH is not natural, and GH receptors can downregulate over time ("GH resistance").
That's why Tesa is very effective at reducing visceral fat at doses inducing much lower levels of GH/IGF than required to achieve similar fat lipolysis with rHGH. The pulses don't cause a loss of receptor responsiveness that occurs with constant exposure to GH. Visceral fat reduction is Tesa's main reason for existence, but it provides the other familiar rHGH benefits on skin, hair, nails etc at a level roughly similar to 2iu of rHGH.
So this makes for a good anti-aging, general health use case vs inherently riskier rHGH. Tesa is a modest GH increasing minivan with an automatic transmission, while rHGH is a manual sports car with no safety features by comparison, requiring monitoring of glucose, IGF, kidney function, lipids, getting timing right, managing sides etc.
