Type-IIx
Well-known Member
Estrogens are in fact vital to male functioning: estrogens are integral to lipid management, male sexual functioning, bone growth, glucose & lipid metabolism, skeletal muscle function (strength and mass)[1][2].
Men produce estrogens via the process of aromatization (Aromatase enzyme). Testrosterone produces E2 (17β-estradiol; a potent estrogen). These products of Aromatase ("Aromatic products") can be increased by increasing the dose of aromatizing androgen (e.g., Test, Deca, EQ, Dbol, MENT), which serves to maintain a positive androgen/estrogen ratio: a positive androgen/estrogen ratio dictates male sexual functioning and prevents gynecomastia [1].
Conversely, exogenous estrogens (estrogens consumed orally, transdermally, intramuscularly, or via whichever conceivable route of administration) pose great harm to men. Indeed, these hormones should only be used by men committed to transitioning (transwomen).
Exogenous estrogens:
✖ cause male reproductive pathologies [1] - even when exposure is to environmental estrogens, far less potent than E2 and in very low concentrations
✖cause an increase in IGFBP-1, decreasing IGF-I bioavailability [3]
✖cause a dramatic increase in SHBG (reducing T bioavailability) [4]
Aromatic products ✓ (positive effects)
Exogenous estrogens ✖ (negative effects)
______________________________
References:
[1] Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiol Rev. 2017 Jul 1;97(3): 995-1043. doi:10.1152/physrev.00018.2016.
[2] Chidi-Ogbolu N, Baar K. Effect of Estrogen on Musculoskeletal Performance and Injury Risk. Front Physiol. 2019;9:1834. Published 2019 Jan 15. doi:10.3389/fphys.2018.01834
[3] He, X., & Barkan, A. L. (2020). Growth hormone therapy in adults with growth hormone deficiency: a critical assessment of the literature. Pituitary. doi:10.1007/s11102-020-01031-5
[4] Damewood MD, Bellantoni JJ, Bachorik PS, Kimball AW Jr, Rock JA. Exogenous estrogen effect on lipid/lipoprotein cholesterol in transsexual males. J Endocrinol Invest. 1989 Jul-Aug;12(7):449-54. doi:10.1007/BF03350728.
Men produce estrogens via the process of aromatization (Aromatase enzyme). Testrosterone produces E2 (17β-estradiol; a potent estrogen). These products of Aromatase ("Aromatic products") can be increased by increasing the dose of aromatizing androgen (e.g., Test, Deca, EQ, Dbol, MENT), which serves to maintain a positive androgen/estrogen ratio: a positive androgen/estrogen ratio dictates male sexual functioning and prevents gynecomastia [1].
Conversely, exogenous estrogens (estrogens consumed orally, transdermally, intramuscularly, or via whichever conceivable route of administration) pose great harm to men. Indeed, these hormones should only be used by men committed to transitioning (transwomen).
Exogenous estrogens:
✖ cause male reproductive pathologies [1] - even when exposure is to environmental estrogens, far less potent than E2 and in very low concentrations
✖cause an increase in IGFBP-1, decreasing IGF-I bioavailability [3]
✖cause a dramatic increase in SHBG (reducing T bioavailability) [4]
Aromatic products ✓ (positive effects)
Exogenous estrogens ✖ (negative effects)
______________________________
References:
[1] Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiol Rev. 2017 Jul 1;97(3): 995-1043. doi:10.1152/physrev.00018.2016.
[2] Chidi-Ogbolu N, Baar K. Effect of Estrogen on Musculoskeletal Performance and Injury Risk. Front Physiol. 2019;9:1834. Published 2019 Jan 15. doi:10.3389/fphys.2018.01834
[3] He, X., & Barkan, A. L. (2020). Growth hormone therapy in adults with growth hormone deficiency: a critical assessment of the literature. Pituitary. doi:10.1007/s11102-020-01031-5
[4] Damewood MD, Bellantoni JJ, Bachorik PS, Kimball AW Jr, Rock JA. Exogenous estrogen effect on lipid/lipoprotein cholesterol in transsexual males. J Endocrinol Invest. 1989 Jul-Aug;12(7):449-54. doi:10.1007/BF03350728.