Neurocognitive Effects of Supraphysiological rhGH + Filtration

[Ateam2023]

Jfc ,

 

[Wrangel7]

My reply was a good-faith attempt to reassure you - the amyloid-seeding thing is a non-issue, and there are much simpler, reversible explanations for what you’re feeling.

I apologise if my laziness (using Grok and not bothering to refine the output) or calling you paranoid came off as dismissive of your genuine concerns.

Hope the MRI comes back clean and you feel sharp again soon.

Thank you. I noticed the edits you made to your comments and I appreciate the new spirit of the messages.

 

[Wrangel7]

Anti cardiolipin antibodies elevated.

@VikingMD thoughts?

Furthermore, thoughts on sbt-272/spn10?

 

[just some dude]

since pinning lots of unfiltered peps and hgh i have been getting cortisol spikes and immune responses. time to start filtering

 

[VikingMD]

Anti cardiolipin antibodies elevated.

@VikingMD thoughts?

Furthermore, thoughts on sbt-272/spn10?

View attachment 367304

Pretty non-specific but there is some literature suggesting it can be associated with brain injury.

 

[Wrangel7]

Pretty non-specific but there is some literature suggesting it can be associated with brain injury.

New results. Still awaiting access to the imaging results.

There is now more than one "independent" antiphospholipid marker in this case.

 

[Billbo98]

Actually comical. According to your output: I (ghoul) criticise (ghoul) and disagree with (ghoul) and use (ghoul)'s comment to contrast the other (also ghoul)'s comments.

I (ghoul) call out (ghoul) for cropping out c-hGH from the article as I (ghoul) admit.

Ghoul is also responding to and arguing with ghoul in the other thread. Awesome.

@Ghoul apparently, we are all you.

In fact, Grok (in your instance) thinks I (not to make any excessive epistemic claims here, though, about its knowledge of me) am this ghoul-amalgam so it technically did not call me paranoid in the first place but rather it called this ontologically distinct thing which does not actually exist paranoid.

However, if we are misattributing mental states to others, perhaps calling you delirious wouldn't be as big of a leap!

Bro have you actually sent a vial in your stock off for endotoxins? I’ve sent several from different batches and all have come back welllll within limits for Pharma drugs. Most recent ones were very low. You’re worrying for nothing man.

 

[Wrangel7]

Bro have you actually sent a vial in your stock off for endotoxins? I’ve sent several from different batches and all have come back welllll within limits for Pharma drugs. Most recent ones were very low. You’re worrying for nothing man.

Am I? Quite a few people may have confused my address of @Ghoul's points with my own points.

Now there is a question of whether these hGH fibrils from the vial survive and reach the brain in a meaningful manner for this context after say SC or IM injection.

So, regarding rhGH fibrils specifically, I think we are lacking evidence that the injection of this non-pharmaceutical product leads to amyloid-mediated brain diseases, especially not as quickly as in this case here.

 

[Billbo98]

Am I? Quite a few people may have confused my address of @Ghoul's points with my own points.

My bad G

 

[Ghoul]

Am I? Quite a few people may have confused my address of @Ghoul's points with my own points.

In pharma, a contaminant isn’t considered “ok” until it’s proven dangerous. Every contaminant a manufacturing process can create has to be identified, documented, and its risk evaluated to get FDA approval (simulators like Epivax are used for this).

This expensive, time consuming process isn’t used because they’re looking for busywork. it’s because with proteins, unlike small molecule conventional drugs, it’s understood there’s a universe of “low probability catastrophes” possible from impurities. How many random novel impurities are created by UGLs making rHGH?

Any change to manufacturing, packaging or handling that could create new types of contaminants has to go through this process again and get FDA approval.

While iatrogenic Alzheimer’s has only been proven with old, human-derived GH, there’s a unique risk with amyloid-like fibrils in rHGH. These needle-shaped aggregates aren't just 'dead' medicine, they’re structural templates. We don’t even have to guess if we’re being exposed to them, we are.

While not exactly like prions, even if they don’t (and we don’t know this) act on neurons, there’s no question from a mechanistic standpoint they can act as protein ‘seeds’, causing a chain reaction of misfolding. This 'cross-seeding' is the same process that drives many diseases, making any fibril shaped aggregate a potential long term threat.

It’s recognized as a significant enough threat to be standard practice for pharma to use a unique testing process to ensure the complete absence of this type of aggregate from pharma protein / peptide drugs.

Meanwhile, we have to weigh whether the vial full of visible fibrils qualifies for “just pin it bro”, and hope that one in a million, or billion, chain reaction of doom molecule isn’t in there.