Search results for query: Clearance

And other great points by B Ware. The nitty gritty details on what determines your free T vs dose comes down to (1) clearance and (2) volume of distribution. Together they set your apparent elimination rate constant. If you search on here @Elvis755 there's a bunch of posts gathering dust (or...

Yeah I've used this and Now unflavored isolate. 5 lb for about $75. I admit to using SixStar stuff. I found a bunch of the 2 lb containers at Walgreens one time for 13 bucks a piece. Ordered them all. Clearance.

Serum FT levels (and serum TT via SHBG) are related to dose via the hepatic clearance of free testosterone. https://en.wikipedia.org/wiki/Clearance_(pharmacology) This is only modestly correlated to body mass. Thank you for differentiating TRT vs cruise which are completely different animals...

Thanks. So a true trough plus an extra day. Your clearance does appear high which gives you the low percentile dose response on the graph I shared. Nothing extraordinary or surprising about your response. Good job getting the LCMS TT assay.

Interesting. Thanks for sharing that extra info. Very helpful. Yes your clearance is extremely high. https://derangedphysiology.com/main/cicm-primary-exam/required-reading/pharmacokinetics/Chapter%20333/clearance

...put all the published studies on there along with various forum members for some crowdsourcing (I have a mkre recent one posted somewhere). Unfortunately all the spread in TT includes SHBG variation which then hides the clearance info you'd get with a plot using FT. Kinda fun though...

...of the ester depot absorption. They offer absolutely no synergistic effect with the Test ester though unless your hypothesis is that BB changes liver clearance of the testosterone which could theoretically alter the serum concentration and AUC for a given amount (mass) of Testosterone...

It seems to skew the eGFR (based on creatinine) by improving creatinine clearance in someone with healthy kidneys and also may exert beneficial effects on the kidney in persons with renal dysfunction. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.706617/full...

...And yeah I tried with lots of caffeine since I am loaded up on caffeine (coffee) everyday. Caffeine/coffee do influence the clearance of some drugs and hence AUC but nothing like what is claimed in the oxandrolone paper. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397437/ A 20x increase...

...I have also collected some data applicable for those on exogenous T and orals. I now have reasonable suspicion that 17AA AAS induce temporary reduction in liver clearance of Test which impacts AUC and observed FT level.

Same to you. Your opinion of my likeablity is irrelevant. I see I made a mistake and assumed both plots were same ester. That was my bad assuming you were making a valid comparison of same amount of tren per week. Why would you give an example of tren A vs tren E for the same mg/week...

...that SHBG affects your FT value while on exogenous Testosterone. It does not. Your FT will be proportional to dose and dependent on your liver's clearance of free testosterone from the body. Often times SHBG may be correlated with clearance (age, obesity, ...). Correlation not causation.

...status (that term is silly in this field anyway). Perhaps the occasional outlier (on the extreme outskirts for distribution volume and/or clearance), but in no way is 200 mg/week of test ester a typical or standard TRT protocol. Unclear what this means. Also biochemistry is mispelled. If...

...really make any sense at all? Think about the 2 parameters that govern pharmacokinetics of injectable Test ester: distribution volume and clearance. What governs these? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915615/figure/psp412287-fig-0001/...

Also please note the unfortunate error the authors made on the ordinate axes label. Should be pg/ml not ng/dl.

...to the ratio of Vmax (the maximal rate of conversion of total or free testosterone to the metabolite) divided by MCR (the metabolic clearance rate of the total or free metabolite); the B parameter corresponds to the Km value for the enzymatic conversion of total or free testosterone to the...

https://thinksteroids.com/community/threads/friends-blood-work-underdosed.134420111/post-3175034 https://thinksteroids.com/community/threads/tool-to-assess-your-tt-dose-response-percentile-curves.134420004/post-3171797

The above? That would be pharmacokinetics (what the body does with the administered drug, serum dose response, clearance, etc.). PD is what the drug does with/to the body (regulatory changes, androgen receptor, gainz,...) once the drug gets in.

...don't. You are slightly familiar with the concepts but don't understand them. That is exactly what I am doing....two parameters control: clearance and distribution volume. See references in early post or here: https://pharmacy.ufl.edu/files/2013/01/5127-28-equations.pdf Clearance...

I would avoid using the term "high responder" or "low responder" when digesting the information in this thread. I certainly did not introduce such language as helpful (quite the opposite - see quotation below)... My goal was to quantify mean serum TT levels (confidence intervals) vs weekly...

30 min time edit limit kicked in LOL. This 30 min edit stuff is BS when dealing with topics and data you won't even get in the academic literature.

...i get it) instead is FT dose response which would then not have the SHBG baggage built in and would depend on true PK parameters...clearance and distribution volume. These later two clearly change with age and affect how men process exogenous T. Now if we can get guys to understand this...

...first pass) where it presents at reduced systemic serum concentration (vs concentration upon introduction into portal vein) and metabolic clearance typically first order function of serum concentration, I can see where this concept has legs although effect may be quite minimal with highly...