2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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I have to big up this site and those who take time to furnish so much information. It's so helpful, timely and appreciated[|)] . From the medical details provided, the information is clearly well researched and trustworthy too. :D How I wish I could get a nice pm from/about a reputable source who's also trustworthy, and save me taking chances with mexican websites no-one's ever heard of.
 
I received white "dnp" tables from an Asian source. I suspect it is fake because the tons of information I have digested about DNP indicates it is a capsule with a pervasive yellow dye.

The tablet is about the size of a penny. GLT is written on one side and it is scored deeply on the other side. One tablet is supposed to be 200 mg.

I took 1/2 tablet a day for six days but did not experience any of the DNP sides, but then again I lost 5 pounds in one week. Coincidence?

Here are the pictures:

http://home.comcast.net/~jadjei/dnp1.jpg
http://home.comcast.net/~jadjei/dnp2.jpg
 
kwei said:
I received white "dnp" tables from an Asian source. I suspect it is fake because the tons of information I have digested about DNP indicates it is a capsule with a pervasive yellow dye.

The tablet is about the size of a penny. GLT is written on one side and it is scored deeply on the other side. One tablet is supposed to be 200 mg.

I took 1/2 tablet a day for six days but did not experience any of the DNP sides, but then again I lost 5 pounds in one week. Coincidence?

Here are the pictures:

http://home.comcast.net/~jadjei/dnp1.jpg
http://home.comcast.net/~jadjei/dnp2.jpg
Interesting tabs. You'd definitely expect them to be yellow. The fact that they're not makes me really suspicious.

You wouldn't experience any sides at 100mg/day even if they were accurately dosed.

Yes, coincidence. Or maybe they were diuretics? lol
 
Conciliator,
What are your thought on long cycle, I was reading Heretic stuff and he seems to say that after 9 days or so the fat loss effect of DNP is greatly diminished.

What do you recommend more : 21days cycle at low dose OR 9 days cycle at moderate dose but cycled like 9week on, 2 week off, 9week on, 2week off.... Until the goal weight is reached?

Also I seem to understand from some of your post that after the cycle there's an anabolic rebound, how do you suggest to take momentum out of it?

Thanks.
 
NPayette said:
Conciliator,
What are your thought on long cycle, I was reading Heretic stuff and he seems to say that after 9 days or so the fat loss effect of DNP is greatly diminished.
There is some tolerance to the drug that's often seen after a couple of weeks, but it's nothing that you can't overcome by slightly increasing your daily dose. Tolerance was noted in the original studies and they dealt with it by simply upping the dosage of DNP.
NPayette said:
What do you recommend more : 21days cycle at low dose OR 9 days cycle at moderate dose but cycled like 9week on, 2 week off, 9week on, 2week off.... Until the goal weight is reached?
I think either can work well. At the lower dosage, progress may slow down if you don't increase the dosage upon developing tolerance. It's good you're using P's 100mg caps, because you can make smaller jumps to accomplish this. At a moderate dosage, the converse is true. You may need to decrease the dosage if the production of heat becomes excessive and your temperature rises too much. Either way, you'll need to monitor your progress, your temperature, and the degree of side effects.

How long a cycle you want to run and at what dosage is really about compromise. One is not clearly better than the other. Shorter cycles will give you a psychological break, more time off cycle to work on preserving/building muscle, but less fat loss overall, unless you want nasty side effects from higher dosages (and the accompanying risks). Longer cycles will give you more fat loss, steady blood levels of DNP, and a better safety profile IMO, but will require more work for a longer period of time. Longer cycles might also result in more muscle muscle loss than with shorter, cyclical use, though DNP appears to be anti-proteolytic (protein sparing).

Personally, I favor longer cycles at a lower dosage, starting at 200 mg/day and increasing to 300-400mg/day, as necessary. I couple this with a good diet and a daily caloric deficit of 500-1000 Cal. In this way, the DNP is more a complement to my natural progress, rather than running the show while my diet goes to crap.
NPayette said:
Also I seem to understand from some of your post that after the cycle there's an anabolic rebound, how do you suggest to take momentum out of it?
It's variable. I never got much of a rebound, but others report awesome results after discontinuing use. If you want to take advantage of it, I'd carb load for 2 or 3 days after stopping the DNP. During this time, drink plenty of water and get into the gym and lift heavy.
 
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Questions?

New to the forums, but have been reading a LOT over the past few days. I have some questions, and I was to make sure I'm on the right track before taking off with this stuff:

1. Do I need to take T3 with it? I plan on running on just DNP for a cycle (same for normal sups/vitamins)

2. I've read the 60/30/10 rule in a few places (or the different variations). I read a little in here, but what about sugars? Stay completely away from them? I read about the guy eating Krispy Kreme, and I assume the carbs and sugars didn't help

3. How often are people measuring their temperature? Once a day? Twice? Only if they feel hot?

4. Do I want to stay on a cut calorie diet? I eat fairly small amounts as it is now, with shakes for protein 3-4 times a day. I hear a LOT about people getting cravings for stuff, but I think I am past that point.

5. Can I continue to do cardio 4-5 days a week on a cycle, as well as mild lifting (since heavy lifting is out) 4-5 days as well?

Thanks for the help in advance. I think finding this forums was godsend =)

Also, you guys are fucking hilarious. I don't know how many times I had to stop reading due to laughing so hard.
 
Re: Questions?

More questions!

6. Do I want to eat in bulk, or spread out like I normally do? I normally have oatmeal, fruit and protein in the am, along with Multi's, then eat 1/2 of my lunch around lunch, the other half around 3-4 with a protein, a protein pre workout, a protein post and a light dinner. Some people say they cut hard hard, but I am just trying to get a real good grasp on this before I start
 
Re: Questions?

baughb said:
New to the forums, but have been reading a LOT over the past few days. I have some questions, and I was to make sure I'm on the right track before taking off with this stuff:

1. Do I need to take T3 with it? I plan on running on just DNP for a cycle (same for normal sups/vitamins)

2. I've read the 60/30/10 rule in a few places (or the different variations). I read a little in here, but what about sugars? Stay completely away from them? I read about the guy eating Krispy Kreme, and I assume the carbs and sugars didn't help

3. How often are people measuring their temperature? Once a day? Twice? Only if they feel hot?

4. Do I want to stay on a cut calorie diet? I eat fairly small amounts as it is now, with shakes for protein 3-4 times a day. I hear a LOT about people getting cravings for stuff, but I think I am past that point.

5. Can I continue to do cardio 4-5 days a week on a cycle, as well as mild lifting (since heavy lifting is out) 4-5 days as well?

Thanks for the help in advance. I think finding this forums was godsend =)

Also, you guys are fucking hilarious. I don't know how many times I had to stop reading due to laughing so hard.
1. Don't worry about not taking T3 with your DNP. It's not clear that DNP will lower thyroid levels anyway, which is why I don't recommend supplementing with T3.

2. You'll lose wight regardless of the type of diet. There's no magic macronutrient ratio. I think a mixed diet is the best option. I'd recommend eating at least some carbs to prevent lethargy.

3. Once or twice a day should be good. I'd measure it a couple of hours after dosing your DNP.

4. Yes. Implementing caloric restriction with your diet will speed the rate of fat loss. 500 Cal below your normal maintenance intake works well.

5. I'd go easy on the cardio. If you can, try to get in and lift heavy once or twice a week. I'd add cardio or higher rep work on top of the heavy work if you feel up to it.

6. It shouldn't matter how often you eat as long as you're getting at least 3 meals a day. If you want to spread things out like you've been doing, there's nothing wrong with it.
 
NPayette said:
Conciliator,
What are your thought on long cycle, I was reading Heretic stuff and he seems to say that after 9 days or so the fat loss effect of DNP is greatly diminished.

Thanks.
I do 20 day cycles now and always have to up the dose slightly somewhere around day 12-14 to keep things going.
 
Re: Questions?

Awsome! Thanks Conciliator. You still seem to be well on top of the DNP knowledge =)

If I do an EC stack, should I do EC or ECA or does it really matter?

Also, what is your thinking of casein vs whey while on DNP? I read to use casein or food protein over whey (unless before a workout). Did i read that properly?
 
Re: Questions?

baughb said:
Awsome! Thanks Conciliator. You still seem to be well on top of the DNP knowledge =)

If I do an EC stack, should I do EC or ECA or does it really matter?

Also, what is your thinking of casein vs whey while on DNP? I read to use casein or food protein over whey (unless before a workout). Did i read that properly?
The aspirin will add little to the stack. It's usually included to prolong the effects of the other two. Most people don't include it. I wouldn't worry about it.

Casein protein is superior to whey when dieting. You heard that correctly. Here's an example: http://www.ncbi.nlm.nih.gov/entrez/...10838463&query_hl=6&itool=pubmed_ExternalLink. The casein group lost substantially more fat and gained more muscle than the whey protein group. Whey is best reserved for around training. Milk protein is about 80% casein and 20% whey.
 
Hello,

I am actually new to THIS site, but last night was the first time I took DNP. I took 200mg, and thus far I have not begun to get hot or sweaty or anything of that sort, I am just so thirsy I can't stop drinking water. Anyone who has taken this before, I have been reading on this for months before deciding to order and I was under the impression that the heat was nearly instant once it got into your system, was I mistaken or will it come with time and more doses? Thanks for the help :-)

MC 2006
 
misscalifornia2006 said:
Hello,

I am actually new to THIS site, but last night was the first time I took DNP. I took 200mg, and thus far I have not begun to get hot or sweaty or anything of that sort, I am just so thirsy I can't stop drinking water. Anyone who has taken this before, I have been reading on this for months before deciding to order and I was under the impression that the heat was nearly instant once it got into your system, was I mistaken or will it come with time and more doses? Thanks for the help :-)

MC 2006
Yes, you're mistaken. Most people don't feel extra warmth until day 4 or 5 at 200mg/day. Many others don't feel heat until bumping up the dosage to 400mg/day. Hearing this from you makes me wonder what sources you were reading. The only place I can recall reading such a claim is in a grossly inaccurate article on DNP that Anthony Roberts did for T-mag. It was one of the worst, propagandist, pieces of trash ever published on DNP. The article is worthless.

The heat will come with time and more doses. PLEASE do not increase your dosage prematurely just because you're not feeling the side effects. Doing so is a great way to get yourself into trouble fast. Instead, keep to your dosing schedule and take a given dose for at least 4-5 days before you even consider increasing it. Monitor your temperature and discontinue the DNP if it ever exceeds 99.2 degrees. This is what Simkins did in his extensive study in DNP in humans in 1937. It's a good, objective measure of your situation and can warn you of impending toxicity long before it's too late.
 
New here. Been reading up on DNP. Conciliator, read many, many of your messages on this forum and others. I am a long time EC user, but I am looking to try something new.

As opposed to doing an increasing cycle over three weeks, I was thinking of a steady 200mg cycle over 5 weeks. Is this advisable? My thoughts on this would be to minimize sides, but still lose an acceptable amount of fat. I am also very skeptical of sources availble.
 
liteweight said:
New here. Been reading up on DNP. Conciliator, read many, many of your messages on this forum and others. I am a long time EC user, but I am looking to try something new.

As opposed to doing an increasing cycle over three weeks, I was thinking of a steady 200mg cycle over 5 weeks. Is this advisable? My thoughts on this would be to minimize sides, but still lose an acceptable amount of fat. I am also very skeptical of sources availble.
There's nothing wrong with a longer, 5 week cycle of DNP. Many people have taken DNP for months at a time. However, you might end up wasting your DNP if you stick to 200mg/day. In 1937, Simkins did an extensive study on DNP in 100+ subjects. He found that there was a rapidly developing tolerance to the drug in the first couple of weeks of use. His solution, as was Cutting and Tainter's, was to simply increase the dosage of DNP to overcome the tolerance and keep fat loss humming along. I think that 200mg/day may be low enough that after 1-2 weeks you will have largely adapted to it. At this point, additional days at 200mg/day would have greatly reduced effectiveness. This may not happen to all people who take DNP, but it's certainly a common phenomenon. For this reason, I'd plan to increase your dosage if after 1-2 weeks you notice few to no side effects.
 
ive been researching DNP for a couple years now, but only recently read thru this whole thread, which is by far the most informative. i actually decided to never take DNP after reading anthony roberts article over at t-nation, but through reading about other peoples experience iv come to the conclusion his article was pretty inaccurate? or at least hyped up the side effects a little.

this post is basiccally for conciliator (your advice seems safe and accurate), im 5ft 9, 205, 12%bf, looking to do a 8ish week cut to get to about 5-7% incorporating DNP.

how does this sound:

one week of high protien, moderate fat, low carb diet (to prepare for DNP)
followed by 5days 200mg DNP per day, then 4days 400mg perday. (40:40:20 diet whilst on)
two weeks of high protien, moderate fat low carb diet
followed by 5days 200mg DNP per day, then 4days 400mg perday. (40:40:20 diet whilst on)
one week of high protien, moderate fat, low carb diet

Am i on the right track or would you advise something a little different? im using the 9days on DNp as after this you said the effect diminishes.

i look forward to your advice. cheers
 
Yeah, in my opinion Robert's article was a plug to get people to eschew more powerful weight loss drugs in favor of Biotest products. Or maybe he just wanted some publicity to look more like a badass who has tried it all. Whatever the reason, it was a terrible misrepresentation of DNP.

Your plan looks good. Two short cycles of DNP at low-moderate dosages. Two weeks in between is enough to regain your sensitivity to DNP. If you're cutting calories throughout it all, you should see some nice fat loss with minimal side effects.
 
That seems about what I am going to try as well, but also running EC, as that seems like a good way to keep the fat loss high.

Hopefully I will have the strength/energy to continue some type of workout throughout the weeks on the cycle =)

Back to the questions for conciliator, I am currently running EC 25/200 Twice a day. I also take animal pumps, which is their pre-workout NO, creatine, and caffine mix. Is that too much caffine? I have read plenty of studies about caffine not really having major negative sides, and I don't drink coffee or anything else along those lines during the day.
 
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