Type-IIx
Well-known Member
Trennnnnn is synergistic with rhGH MOST of all, but it's not the answer to the quiz 
MESO-Rx
Anabolic Steroids
A GH and fat loss protocol (rhGH lipolysis) that is science-based
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Type-IIx
Well-known Member
I'll put it like this: there are more options for synergistic combination beyond trenbolone and testosterone. Those are the ones I talk about most, but think about what additionally synergy means when combined with already synergistic combos... gains++
The drug I am thinking about I have written about before and look at the call of the question, "by augmenting IGF-I bioavailability."
Think free, unbounded IGF-I. What frees up IGF-I?
The drug I am thinking about I have written about before and look at the call of the question, "by augmenting IGF-I bioavailability."
Think free, unbounded IGF-I. What frees up IGF-I?
Bronze6Actual
New Member
Type-IIx’s favorite words are:
-synergy
-synergies
-synergistic
-synergic
-synergistically
-synergies
-synergizing
-synergized
-synergy
-synergies
-synergistic
-synergic
-synergistically
-synergies
-synergizing
-synergized
Type-IIx
Well-known Member
Absolutely
AlexDavis43
Member
So what's the answer to the quiz? or are you gonna keep it running until some gets it right
Type-IIx
Well-known Member
People have been getting it right, I set it to 7 days and it’s only been 2 since I created the poll, 4 since the video dropped.
The quiz is live on Discord and Telegram, don’t know whether you use either.
On Telegram, it’s in quiz mode, where if you answer incorrectly it gives you the answer and an explanation.
So the polls end in another 4 — 5 days.
Bronze6Actual
New Member
The answer is synergistic synergy sinergizes
Ateam2023
Well-known Member
STFU!!!
readalot
Member
Stanozolol Insights: Unique Characteristics of Anabolic-Androgenic Steroids – Part 2
Learn the unique features of Stanozolol (Winstrol), an anabolic steroid with enhanced half-life, IGF-I modulation, glucocorticoid effects, and joint pain.
thinksteroids.com
Is this correct?
So just like with testosterone, does reducing the concentration of binding protein really increase the absolute concentration of free hormone? Or just increase the relative percentage of free hormone by driving down total hormone concentration?
Do oxandrolone, danazol, stanozolol free up more T? Hint: see Fig above. Only transiently. Think about the actual turnover time of bound Testosterone. On the order of 1 min IIRC? At steady state no change to free hormone, which is proportional to exogenous dose, unless the drug also affects hormone elimination rate in addition to reducing binding protein concentration.
Fascinating parallel with IGF-1 / IGFBP. Thanks for bringing this up.
I still struggle to see how reducing SHBG frees up more T. It doesn't. Hopefully the situation is different with IGFBP/IGF-1.
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Type-IIx
Well-known Member
Combination Strategies
- Synergistic (greater than additive; 1 + 1 > 2): achieved when the same end-point is increased by different mechanisms by different factors. For example, acting on skeletal muscle hypertrophy as an end-point, combining an AAS that increases circulating IGF-I levels (e.g., GH) with an agent that increases the satellite cell proliferative responsiveness to autocrine/paracrine IGF-I (e.g., trenbolone).
- Complementary (middling-out; 1 + -1 = 0): achieved when the same end-point is increased by one factor and decreased by another factor. For example, acting on blood glucose levels, GH increases blood glucose whereas IGF-I decreases it.
- Additive (standard dose/response; 1 + 1 = 2; everything else): achieved when the same end point is increased by different factors by the same mechanism. For example, acting on skeletal muscle hypertrophy, combining Masteron and Primo. Both act as straightforward AR agonists.
MenuItem78
New Member
I noticed my HRV (heart rate variability), seems to drop a lot when I take GH before bed any idea why this would happen ?
Type-IIx
Well-known Member
Whenever we're talking HRV, on a board like this, we must unpack:
For starters, let's dismiss with all illusions: HRV is primarily a measure of cardiac function. We refer to the autonomic nervous system, the Russians and those researchers and practitioners within their spheres of influence refer to this as the vegetative system and speak of variable phase and somatic states.
At bottom, heart rate variability (HRV) is defined as the variability in the interbeat (R-R) interval (or the N-N interval after abnormal beats have been eliminated from a recording), and is a measure of the state of arousal of the autonomic nervous system such that higher HRV reflects higher parasympathetic activity or tone, reflecting a state of transition to regeneration of homeostasis of the organism [comrade], etc.
rMSSD is defined as the square root of the mean squared successive differences of interbeat R-R interval.
SDNN is defined as the standard deviation of the N-N interval (after abnormal beats have been eliminated from a recording).
Short time samples can be evaluated in the time domain, i.e., analyzed for the variability in the difference in successive beats (ms).
Longer HR recordings can be analyzed in the frequency domain - sometimes referred to as a power spectral analysis - where HRV fluctuates with varying frequencies.
The time domain measures of HRV are analogous to measuring the overall flux of light from a star.
The frequency domain measures of HRV are analogous to analyzing the spectrum of frequencies of light emanating from the star to provide insight into its chemical reactions and composition (120).
Note: Thanks are owed to Dr. Scott Stevenson for his most vivid descriptions of these HRV aspects.
Finally, after these definitions, we can establish that, using acromegaly as a model of GH/IGF-I excess, HRV is suppressed in these patients because of effects on cardiovascular function and by virtue of those effects, on sympathetic tone. [1].
Note: I have discussed the practical limitations that might fairly be summarized as uselessness of using HRV to estimate changes to strength, i.e., performance for resistance training sessions in the weight room here:
View: https://www.youtube.com/watch?v=VU4LA2-n_1Q
This is because changes in muscular strength or performance are primarily mediated by changes in excitation-contraction coupling and calcium ion fatigue rather than cardiac function.
From [1]:
Results: Acromegalic patients showed significantly lower SDNN and SDANN compared to controls. Diabetic and non-diabetic acromegalic patients showed decreased SDNN and SDANN, when compared to healthy subjects. Diabetic acromegalic patients had a lower LF/HF ratio during 24 h when compared to non-diabetic acromegalic patients. Similar results were obtained analyzing patients affected by acromegaly and impaired glucose tolerance. SDNN and SDANN were lowered by hypertension in the acromegalic population, when compared to controls, and hypertensive acromegalic patients also displayed a decreased LF/HF ratio during 24 h when compared to normotensive acromegalic subjects. Patients with ventricular arrhythmias in Lown classes 3-5 showed a decreased SDANN compared to patients in Lown class 0-2. The treatment with SSAs was able to ameliorate all the time domain parameters of HRV, without altering the 24 h LF/HF ratio.
Conclusion: Cardiac autonomic functions and sympathovagal balance are altered in patients affected by acromegaly and could be ameliorated by SSAs [somatostatin analogues, that block GH hypersecretion] therapy. HRV analysis allows an estimation of the autonomic sympathovagal balance and may be a useful clinical tool for the cardiac risk stratification in acromegalic patients.
[1] Comunello A, Dassie F, Martini C, De Carlo E, Mioni R, Battocchio M, Paoletta A, Fallo F, Vettor R, Maffei P. Heart rate variability is reduced in acromegaly patients and improved by treatment with somatostatin analogues. Pituitary. 2015 Aug;18(4):525-34. doi: 10.1007/s11102-014-0605-6. PMID: 25261332.
Type-IIx
Well-known Member
Closed up the quiz since it seemed to be tapering off:
Congratulations to our winners!! Not an easy task under honest circumstances!
Discord:
Rexi, datboi, Trades
Telegram
The # of correct respondents was 3, but I can't seem to tell if it was the same users or not. I'll delve.
On that note, I have been told by someone who's pretty technically savvy that I am duplicating too many things across services and it's borderline annoying besides inefficient. I'm beginning to agree! There are benefits, though. Besides Discord not being really that powerful, unlike Telegram, I like the federated design in case anything happens like service interruption.
Qualification: Always true to tempering excitement, it's the coach in me: if your answer was informed by mere subterfuge, just scanning the Meso thread(s) to get the answer, that’s cheating by my standard! I just wouldn't be able to tell who did that, but it's possible
.I know it’s 2024, and that what constitutes cheating has narrowed to paying or otherwise pointing a gun at at a doppelgänger’s head to take the test for you after hanging the test creator from the roof of a Syrian prison by his nipples with meat hooks, but it’s cheating!
The way to properly answer a challenging question is to answer the call of the question, i.e., here, what increases IGF-I bioavailability, i.e., frees up bound IGF-I? That’s the call of the question.
To all who answered the question correctly as stanzololol I applaud you especially if it was a genuine win in your heart you earned it!
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AlexDavis43
Member
Not sure if you plan on venturing into social media to market your swag/services (I do recommend), but this is also true on twitter, facebook, instagram, threads, linkedin, etc.
Similar to discord/telegram, you'll find some content works better on certain sites better than others.
readalot
Member
Chapter 12 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs
Read this chapter. Chapter 12 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs https://www.sciencedirect.com/science/article/pii/B9780323479127000123?via%3Dihub From https://www.sciencedirect.com/book/9780323479127/yen-and-jaffes-reproductive-endocrinology
www.excelmale.com
Excel.exe
Member
@malfeasance thought this might be interesting after reading your post HGH and Heart Rate During Cardio
Type-IIx
Well-known Member
Update: I underestimated the editing and hoops I’d have to jump through with the print company for those of you wondering, the book should be available Wednesday or Thursday. It’s a totally different beast from what’s out there… it’s what I wished I knew
a1622
New Member
Where can I order a copy?
Type-IIx
Well-known Member
View: https://www.youtube.com/watch?v=EUObJPAPIuw
Bolus
A Practical and Reference Guide for the Use of human Growth Hormone and GH Secretagogues
Alright guys, the moment so many have been waiting for is here. I've released Bolus. It's a quality print softcover, premium color, at 138 pages in Executive layout with perfect binding.
It can be purchased at https://ampouletude.com/bookdetails/33
Bolus is a practical and reference guide for the use of recombinant human growth hormone (rhGH; GH) and GH secretagogues (GH releasing peptides).
Bolus represents a breakthrough in planning and designing protocols for contest bodybuilding and anti aging applications.
This research-based text details how to systematically examine the physiological parameters required for crafting an optimal, objective oriented course (protocol) for the purpose of competitive untested bodybuilding.
The author brings years of practical and research work, as a bodybuilding practitioner and coach for contest and lifestyle bodybuilders, in order to share his unique insights concerning planning, designing, and implementing protocols that use this class of growth factors - GH in its recombinant and secretory forms.
This text is written in a manner that challenges professionals, and includes in its intended audience doctors and chemists, while remaining accessible to bodybuilding practitioners and coaches. It begins by giving the reader the basic tools for understanding GH research. This scientific foundation empowers the reader to formulate a sound plan and design process. Next, the text examines how to apply this knowledge using clear worked examples. Finally, a theoretical section that contains basic scientific facts about GH in its recombinant and secretory forms is provided as a reference.
Each section (1. Introduction to Research, 2. Practical Applications, and 3. Theoretical Reference) is written in a standalone manner so that the reader can refer back to the material as needed.
If you'd like a sneak peek at the Table of Contents and first chapter, you can do so by filling in the email field on Bolus - A Practical and Reference Guide... the ONLY GH Book You'll EVER Need! as shown in the attached image.
Merry Christmas!
Type-IIx
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PiscesMoon
Member
Congratulations for your book's release day! @Type-IIx And thank you for sharing the ToC + 1st chapter of Bolus with us.
And thank you for sharing the ToC + 1st chapter of Bolus with us.Similar threads
