MESO-Rx

Anabolic Steroids

Accutane permanent cure?

Ghoul said:
150mg / kg is the top end of the cumulative dosing prescribed by conservative dermatologists in the US, who are only concerned with facial acne (psychological impact on younger people). Provided you take it with food every time for proper absorption, make sure to continue for two months after FULL clearance, 150mg/kg gives you a very high likelihood of a permanent cure, especially since it's moderate.

However, you brought up large pores. Do you have oily skin / hair or just big pores? Large pores usually indicate large sebaceous glands, lots of oil.
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Good to know.

Yes, I have oily skin. No hair since I’m bald and shave it, but my head gets oily and I dislike it. I have been on topical Tretinoin .05% every night before bed for the past year and that seems to have helped shrink pore size somewhat and improved skin quality, but I am still oily and would like them shrunk more. I’ve seen you mention it can permanently shrink the sebaceous glands so wondering what your cumulative dosing suggestion for that is.

Also, say I were to start isotretinoin, do I stop using the topical Tretinoin? Or can I continue to use that for added effect?
 
Is acne mostly a genetic thing?

I've lucked out where I don't really get acne on cycle, aside from the occasional pimple or two (but i attribute this more to sweating for 2+ hours in the gym everyday than I would hormones)

But then there's some people that run mild cycles, and have horrific breakouts.

I guess some people's body's naturally produce more oil?
 
Flyfisher23 said:
Good to know.

Yes, I have oily skin. No hair since I’m bald and shave it, but my head gets oily and I dislike it. I have been on topical Tretinoin .05% every night before bed for the past year and that seems to have helped shrink pore size somewhat and improved skin quality, but I am still oily and would like them shrunk more. I’ve seen you mention it can permanently shrink the sebaceous glands so wondering what your cumulative dosing suggestion for that is.

Also, say I were to start isotretinoin, do I stop using the topical Tretinoin? Or can I continue to use that for added effect?
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Same here dude, i had bad acne on the back even natty because i have really oily skin (my head seems like i sweated sometimes). Luckily i get it only on my back (face, chest,all clear) but i got tired of this shit and also gonna try roaccutan.
 
Ghoul, I didn’t read replies but feel rather expert on the subject. I had crazy oily skin as a teenager and to avoid getting any potential scarring my dermatologist put me on 40mg AM and 20pm.

That dried me out for about a decade. Must have been a large dose for me because my skin was peeling and lips cracked no matter what I did for quite a while. But it was super effective. And that was with Roche brand straight from pharmacy in US.

I’ve used it twice in my adulthood and always went lighter than I probably should have. After several years to think about it I think hard and heavy dosage while monitoring blood work for liver is the best way to use it. Likely never have to use it again if you do that.

Unfortunately all oral steroids will turn those oil glands back on in me so I avoid orals.
 
Ghoul said:
90% of the isotretinoin I've been using on this cycle has been Accufine from Healing Pharma. There are a number of Jano tests out there of various strengths and they always show full potency. They are, of course, the proper oil filled gelcaps not UGl solid dry tabs.

They're available as 5,10,20,30, and 40mg.

The larger doses are less expensive(per mg) however. you want the flexibility to adjust your dose in small increments, especially at the beginning, so going all 40mg isn't a good idea. You also want to split into day/night dosing which helps minimize sides.

So if 220mg/kg was 20,000mg for example, I would go with:

20 strips(10 caps per strip) 40mg
20 strips 30mg
20 strips 20mg
20 strips 10mg

That way you can ease into it with 2x10mg a day for a week, then 2x20mg, then 2x30, 2x40, 2x40+10, 4x30 (ie 2x 30mg twice a day). until you get to 2g/kg max a day, if you can. These high doses are really what's required to knock out shoulder acne,, the hardest to rid.

Sides tend to worsen briefly when increasing dose then settle down so this incremental strategy makes it much easier to deal with than the big jumps usually involved with Dermatologist monthly visits.

Email PCT 24x7 for a price list, he's offering 15% off atm. Cosmic PCT (pricelist.cosmicpct (dotcom) has really good pricing as well, and is doing a buy 3 get 1 strip deal as of this posting.

They're both reliable but PCT24 is a sponsor here so if pricing is close would be good to give him your business.

By comparison, without insurance, using goodRX, the same regimen with generics would be around $2,000+probobly another $1k in derm visits.

PS: If cost is no concern, you could get Isotret NF, which absorbs more easily and not reliant on food, so the doses are reduced by 20% for the same efficacy. IE, 8mg=10mg. I make a point of taking the caps right after breakfast and after dinner, so it's been working. well for me with the regular types. Isotret NF is about double the cost.
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I went by your titration schedule above and ordered exactly as written from Cosmic. Not sure I'm interested in the impending sides. However, I am interested in potential reduction in pore size and tightening of skin. Collagen also seems quite deficient. Over the past 10+ years, I have noticed a marked change in my skin that seems well beyond just normal aging. Used to not be this oily, and the pores on my face are huge, now. The changes did seem to coincide with starting TRT. I'll report back if I don't get depressed and eat a slug.
 
nullandvoid said:
I went by your titration schedule above and ordered exactly as written from Cosmic. Not sure I'm interested in the impending sides. However, I am interested in potential reduction in pore size and tightening of skin. Collagen also seems quite deficient. Over the past 10+ years, I have noticed a marked change in my skin that seems well beyond just normal aging. Used to not be this oily, and the pores on my face are huge, now. The changes did seem to coincide with starting TRT. I'll report back if I don't get depressed and eat a slug.
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Not the advanced studies that show demonstrable collagen improvement in middle aged women with photo-damaged(ie, sun damaged) skin, but a literal "feels" test of pinching my flesh has shown an immediate snap back, rather than the slower return to shape, I haven't seen in a long time.

Mind you, this wasn't noticeable until I was on the other side of the mountain, around 3.5 months and 12,000 or so mg cumulative, crazy skin flaking that made me the primary source of dust in my house, and an entire manufacturing line at the lip balm factory dedicated to my needs.

It motivated me so much to go "all the way" to 220mg/kg it had me scrambling for more accufine after multiple FDA seizures with letters warning of the hazards of the letters "Rx" being in too small a font on the box to possibly be effective or safe for use by an American, Only the UGL I ordered as insurance actually arrived from that batch, and I was forced to use it for a few days until some Accufine managed to show up on a reship,
 
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Ghoul said:
Not the advanced studies that show demonstrable collagen improvement in middle aged women with photo-damaged(ie, sun damaged) skin, but a literal "feels" test of pinching my 50yo flesh has shown an immediate snap back, rather than the slower return to shape, I haven't seen in a long time.

Mind you, this wasn't noticeable until I was on the other side of the mountain, around 3.5 months and 12,000 or so mg cumulative, crazy skin flaking that made me the primary source of dust in my house, and an entire manufacturing line at the lip balm factory dedicated to my needs.

It motivated me so much to go "all the way" to 220mg/kg it had me scrambling for more accufine after multiple FDA seizures with letters warning of the hazards of the letters "Rx" being in too small a font on the box to possibly be effective or safe for use by an American, Only the UGL I ordered as insurance actually arrived from that batch, and I was forced to use it for a few days until some Accufine managed to show up on a reship,
Click to expand...

I hope I can stay the course and keep pushing through the annoyances. I'm very encouraged with what you've posted, as it seems to very closely mirror my experiences. I'm also only around 80kg, so 20000mg should take me past the therapeutic peak.
 
nullandvoid said:
I went by your titration schedule above and ordered exactly as written from Cosmic. Not sure I'm interested in the impending sides. However, I am interested in potential reduction in pore size and tightening of skin. Collagen also seems quite deficient. Over the past 10+ years, I have noticed a marked change in my skin that seems well beyond just normal aging. Used to not be this oily, and the pores on my face are huge, now. The changes did seem to coincide with starting TRT. I'll report back if I don't get depressed and eat a slug.
Click to expand...
I did the same thing this week! I hope to start by January
 
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