Why does anadrol make my gyno flare?
It's likely due to Adrol's:
- tendency to increase 17-OHP, a "weak" progestin [41]. Camerino [126], cites Junkmann and Suchowsky, 1962 that "showed no gestagenic effect" at therapeutic doses. No direct PR binding - moderately to AR, weakly to ER-alpha (weaker than oxandrolone and stanozolol) & ER-beta in mammalian reporter gene bioassay [28]
Progestins are involved in lactation but can enhance the effect of estrogens on breast tissues.
Fluid retention may be due additionally or independently to:
- potential for MR agonism?
- potential activation of RAAS?
The RAAS regulates water and electrolyte balance, connective tissue cell growth, and the metabolism of loose and dense connective tissue or tissue repair, as well as bone metabolism. Pathologically, it increases vascoconstriction, cardiac hypertrophy, fibrosis (i.e., chronic activation may cause myocardial infarction, fibrosis of the liver).
Acting as an agonist to the MR increases aldosterone which increases sodium retention in the renal tubules. In this sense, Adrol may act oppositely of tren in this regard (as methyltrienolone has been demonstrated to act as an
antagonist at the MR).