Best ped for anti-aging ..

[may2021]

just started trt and looking to expand into other peds.. In your opinion/experienced which one is the best anti aging product ? Weight loss, better skin etc ? Is hgh worrh it for that ? There are so many peptides.. little help would be appreciated !

Also I have a crappy back with herniated l4-l5 disks Any peptide that would help there ?


Thanks !

None.
They all age you. Especially growth hormone.
Don't believe the GH anti-aging bullshit. It accelerates cellular division while lining the pockets of quack doctors.

 

[Avies48]

None.
They all age you. Especially growth hormone.
Don't believe the GH anti-aging bullshit. It accelerates cellular division while lining the pockets of quack doctors.

How do they age you? Seriously want some incite into this way of looking at these items… especially gh?

 

[NotHuman]

Flies and mice? 40 days and 2-3 years respectively. That gives no indication of long term consequences.

Yeast, worms, flies, mice and marmosets so far. Here is a good place to learn more for anyone truly interested

Rapamycin Frequently Asked Questions (FAQ)

Rapamycin: The Gold Standard of Life Extension Drugs Rapamycin is, by far, the world’s leading candidate for an effective and accessible longevity (anti-aging) drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of...

www.rapamycin.news

 

[NotHuman]

None.
They all age you. Especially growth hormone.
Don't believe the GH anti-aging bullshit. It accelerates cellular division while lining the pockets of quack doctors.

If a physiological dose is used to treat an HGH/IGF1 deficiency, then I believe it improves lifespan. We already know it's good for heart failure and several other disease conditions, like muscle wasting in the elderly.

Combined effects of growth hormone and testosterone replacement treatment in heart failure - PMC

Although preliminary studies have demonstrated safety and effectiveness of single replacement therapy for growth hormone deficiency or testosterone deficiency in heart failure (HF), no data are available regarding the combined treatment with both GH ...

www.ncbi.nlm.nih.gov

It also regrows the thymus

Reversal of epigenetic aging and immunosenescent trends in humans - PMC

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we ...

www.ncbi.nlm.nih.gov

Bodybuilding doses are another story

 

[Ghoul]

If a physiological dose is used to treat an HGH/IGF1 deficiency, then I believe it improves lifespan. We already know it's good for heart failure and several other disease conditions, like muscle wasting in the elderly.

Combined effects of growth hormone and testosterone replacement treatment in heart failure - PMC

Although preliminary studies have demonstrated safety and effectiveness of single replacement therapy for growth hormone deficiency or testosterone deficiency in heart failure (HF), no data are available regarding the combined treatment with both GH ...

www.ncbi.nlm.nih.gov

It also regrows the thymus

Reversal of epigenetic aging and immunosenescent trends in humans - PMC

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we ...

www.ncbi.nlm.nih.gov

Bodybuilding doses are another story

I think the main "causes aging" argument is that HGH stimulates growth/healing, and there's a limited capacity for cell division before things go wrong and ultimately fail.

In theory slower growth, preserving that capacity, extends max possible lifespan.

Since everyone dies with unused growth capacity, bringing it "forward", at the risk of using it up early, for a better quality of life now vs the possibility of more longevity may be a reasonable trade off.

 

[may2021]

If a physiological dose is used to treat an HGH/IGF1 deficiency, then I believe it improves lifespan. We already know it's good for heart failure and several other disease conditions, like muscle wasting in the elderly.

Combined effects of growth hormone and testosterone replacement treatment in heart failure - PMC

Although preliminary studies have demonstrated safety and effectiveness of single replacement therapy for growth hormone deficiency or testosterone deficiency in heart failure (HF), no data are available regarding the combined treatment with both GH ...

www.ncbi.nlm.nih.gov

It also regrows the thymus

Reversal of epigenetic aging and immunosenescent trends in humans - PMC

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we ...

www.ncbi.nlm.nih.gov

Bodybuilding doses are another story

1. Greg Fahys TRIIM study had a total of 9 participants. NINE. Each using dhea, metformin and gh. To this day he can't show which molecule did what. So, no. gh does NOT cause thymus regeneration.

2. Elevated levels of IGF-1 have been associated with an increased risk of several types of cancer, including breast, prostate, and colorectal cancers. Unregulated cell proliferation can increase the risk of cancer. IGF-1, in particular, has mitogenic (cell division-promoting) and anti-apoptotic (preventing programmed cell death) properties, which can contribute to tumor growth.

So dude. No. Delete your post.

 

[may2021]

How do they age you? Seriously want some incite into this way of looking at these items… especially gh?

See below

 

[may2021]

just started trt and looking to expand into other peds.. In your opinion/experienced which one is the best anti aging product ? Weight loss, better skin etc ? Is hgh worrh it for that ? There are so many peptides.. little help would be appreciated !

Also I have a crappy back with herniated l4-l5 disks Any peptide that would help there ?


Thanks !

SLEEP

 

[Ghoul]

1. Greg Fahys TRIIM study had a total of 9 participants. NINE. Each using dhea, metformin and gh. To this day he can't show which molecule did what. So, no. gh does NOT cause thymus regeneration.

2. Elevated levels of IGF-1 have been associated with an increased risk of several types of cancer, including breast, prostate, and colorectal cancers. Unregulated cell proliferation can increase the risk of cancer. IGF-1, in particular, has mitogenic (cell division-promoting) and anti-apoptotic (preventing programmed cell death) properties, which can contribute to tumor growth.

So dude. No. Delete your post.

According to this, those being treated with GH who had cancer previously were more likely to have a recurrence.

Those who developed cancer while being treated with GH were more likely to have a recurrence while they remained on GH.

Those who never had cancer had no additional risk of developing cancer. from being on GH.

This set of results implies GH doesn't make cancer any more likely, but if it ever appears, increases the odds of it's reappearance. Other studies show cancer is more resistant to treatment in GH patients.

Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk? - PMC

Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in ...

www.ncbi.nlm.nih.gov

 

[may2021]

According to this, those being treated with GH who had cancer previously were more likely to have a recurrence.

Those who developed cancer while being treated with GH were more likely to have a recurrence while they remained on GH.

Those who never had cancer had no additional risk of developing cancer. from being on GH.

This set of results implies GH doesn't make cancer any more likely, but if it ever appears, increases the odds of it's reappearance. Other studies show cancer is more resistant to treatment in GH patients.

Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk? - PMC

Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in ...

www.ncbi.nlm.nih.gov

Very good

 

[NotHuman]

1. Greg Fahys TRIIM study had a total of 9 participants. NINE. Each using dhea, metformin and gh. To this day he can't show which molecule did what. So, no. gh does NOT cause thymus regeneration.

2. Elevated levels of IGF-1 have been associated with an increased risk of several types of cancer, including breast, prostate, and colorectal cancers. Unregulated cell proliferation can increase the risk of cancer. IGF-1, in particular, has mitogenic (cell division-promoting) and anti-apoptotic (preventing programmed cell death) properties, which can contribute to tumor growth.

So dude. No. Delete your post.

From the tone of your post, it appears that you aren't willing to keep an open mind and only want to argue, so I'm replying to your points so that others can benefit. I'd love to have an open, positive discussion on this since it's an interesting topic. However, a "dude delete your post" comment implies you are ideologically attached to your opinion and aren't interested in a discussion.

1. In the original TRIIM trial, 7 of the 9 participants had the exact same dramatic benefit. 7 for 9 is pretty significant if you ask me.
You might want to look into the ongoing TRIIM-X trial, which recently completed its first phase. It has more participants this time, and the results have been replicated so far. It is very much evident that the HGH is what did it, and not the other things. The other things were given to combat the insulin sensitivity side effects from the HGH. Steve Horvath himself decided to mimic the trial but without the HGH, and he did not achieve any thymus regeneration. Your conclusion that the trial is bunk and a waste of time is very pre-mature. It is very much a debate and you would be best served to keep an open mind until the next phases of TRIIM-X are complete, when we get a better picture.

2. I made it very clear in the post you asked me to delete that I was referring to correcting an IGF1/HGH deficiency and not using bodybuilding doses bring IGF1 to supraphysiological amounts.
"Both high and low levels of IGF‐1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality." Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis

 

[serkan]

Can you explain? I believe he is correct with the hgh, higher igf levels are associated with increased mortality, similar to low levels (similar to testosterone levels). People lived longest with below average igf-1 levels. Many studies show this.

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Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis - PubMed

The association between IGF-1 levels and mortality in humans is complex with low levels being associated with both low and high mortality. The present meta-analysis investigates this complex relationship between IGF-1 and all-cause mortality in prospective cohort studies. A systematic literature...

pubmed.ncbi.nlm.nih.gov

"Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality."

How much hgh should I take to get my level to 120-160 ng/ml? I am 49 years old.

 

[malfeasance]

"Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality."

How much hgh should I take to get my level to 120-160 ng/ml? I am 49 years old.

I would need some level of supplementation to get 120-160, although I do not know how much.

My last time natty was 83 . . .

 

[malfeasance]

The chart looks like a U with the bottom being right around 140

 

[Ghoul]

"Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality."

How much hgh should I take to get my level to 120-160 ng/ml? I am 49 years old.

Wait until you're 70-80 years old?




"Anti-aging" and "Longevity" are not the same thing. I'd also be cautious about drawing too many conclusions from "x is associated with y".

If you want to keep your IGF within physiological levels, but higher (ie restoring a more youthful level) than it is now. it's probably easier to accomplish to accomplish that with a secretagogue than hGH.

 

[malfeasance]

I'm already below the average 80 year old.

 

[Ghoul]

I'm already below the average 80 year old.

As long as you had fun getting there. Better to burn out than to fade away and all that...

 

[serkan]

Wait until you're 70-80 years old?

View attachment 306492


"Anti-aging" and "Longevity" are not the same thing. I'd also be cautious about drawing too many conclusions from "x is associated with y".

If you want to keep your IGF within physiological levels, but higher (ie restoring a more youthful level) than it is now. it's probably easier to accomplish to accomplish that with a secretagogue than hGH.

I wrote to you asking for help. Unfortunately I didn't get much back. But thanks anyway.

 

[Benf15harp]

"Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality."

How much hgh should I take to get my level to 120-160 ng/ml? I am 49 years old.

.8ius or roughly 266mcgs is standard starting dose for replacement
Try that and get tested

 

[Tawny]

If you're doing TRT, the next choice in my mind (and I'm not advocating for anyone to do this ) is HGH. Hair, skin, nails all improved. Better sleep also for me. I'm 3 months on HGH, and my midsection looks dramatically different. Everyone gets different results, but I will continue my dose of 3iu per day as long as I can. I also have compressed herniated L3,4,5 and a banged up shoulder. I just started BPC157 a few days ago and plan to start TB500 asap. But I can't say those have helped, too early to tell.

I’ve been thinking about HGH also, but I’ve heard from a few people it makes your organs bigger. Is this true?