Do AAS accelerate degenerative joint disease related processes?
While causal data is limited, its difficult for me to overlook the possibility AAS are in part responsible for arthralgias being the number one complaint in "older" cyclists.
Of course the loads many competitive BB are pushing has something to do with it, but the ability of some AAS to down regulate the glucocorticoid receptor may have paradoxical and untoward physiologic effects. (This relationship may help explain why very few studies support the use of AAS in the post-op orthopedic patient)
Such that while glucocorticoid (such as cortisol) mediated activity is generally "catabolic" with respect to SKM, they are also a critical means of limiting the inflammatory cascade within joints and elsewhere.
Consequently while AAS have not been shown to alter cortisol secretion per se, by suppressing the glucocorticoid receptor, the net effect of AAS may be an inability of cortisol to modulate joint inflammation, and is one reason why older lifters are better off limiting the dose and loads to one of "maintenance" IME.
Just food for thought guys.
JIM