I’ve taken your cialis and I am currently taking it alongside enclom as part of my pct. I am getting erections so there is definitely some amount of drug in the cialis. I bought this fairly recently, 3 weeks ago or so. Usually on pct my downstairs is dead.
getting or not getting an erection is not in any way, a marker of the product containing tadalafil.
Treatment Strategy for Non-Responders to PDE5 Inhibitors
Currently, phosphodiesterase type 5 (PDE5) inhibitors are the initial treatment option for erectile dysfunction. The reported efficacy of PDE5 inhibitors is about 70%, although it is significantly lower in difficult-to-treat subpopulations. Treatment ...
www.ncbi.nlm.nih.gov
REASONS FOR AN INITIAL NON-RESPONSE TO PDE5 INHIBITORS
1. Comorbidities
Several recent studies have suggested that ED can be the initial clinical presentation of underlying cardiovascular disease (CVD).
4 Endothelial dysfunction is a major common mechanism in the development of ED and CVD. Metabolic syndrome (MS) is defined as the clustering of several cardiovascular risk factors, including visceral obesity,
hypertension, dyslipidemia, and glucose intolerance. These components are also risk factors for ED. Esposito et al
5 reported that the proportion with ED was higher in men with MS. Therefore, it is possible that patients with MS respond differently to PDE5 inhibitors. Suetomi et al
6 demonstrated the negative impact of MS on the response to sildenafil.
4. Psychological and partner issues
Patients can have unrealistic expectations, such as considering the drug an aphrodisiac, fear of possible complications or side effects of the drugs, and anxiety about their new sexual life after long-term abstinence due to ED, or have unaddressed psychological issues. Partner issues are equally important and should be addressed. These include female sexual function issues, such as pain, anorgasmia, vaginal dryness, or lack of sexual interest.