MESO-Rx

Anabolic Steroids

MESO-Rx Sponsor Driada Medical

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Gentlemen!
It's Saturday and it’s time for a new giveaway!

You know the rules: you need to subscribe to the channel https://t.me/driadamedicaleu and write "+" in the comment to this post.


On Monday we will select 3 random winners who will receive €50 store credit.

Have a great weekend, everyone!
 
Sterkekoffie1 said:
I use it right now ,
Ive used bayer rimobolan for years but they have some problems with customs ..driada have a good post system and the primo has no pip and like to be legit but i dont have do some blood work so its only my feelings that i told you
Click to expand...
Have you any experience with Quindao Primo? If so do you think its legit? I assume the primo from this supier feels the same as rimobolan?
 
Raz302 said:
Have you any experience with Quindao Primo? If so do you think its legit? I assume the primo from this supier feels the same as rimobolan?
Click to expand...
No im only used bayer rimobolan and now driada .. I must honestly say that because I use primobolan for a long time I don't really know what you must feel I only see the long-term result but primo doesn't give me any sides so I can't judge that.. I've only been taking driada for 5 weeks now i don't see my body deteriorating so i have the idea that driada is just good when i go out on my feelings ..
 
We remind you that tomorrow on our TG channel we will hold a “SUNDAY AUCTION"

We will be waiting for you on our channel TOMORROW from 17:00 UTC +2;)
 
CABERGOLINE


The main side effects of Nandrolone class steroids (including Trenbolone) are associated with an increase in prolactin levels. Prolactin has the most negative effect on men when it rises in the brain. By binding to the progestin receptors of the pituitary gland, nandrolones increase the production of prolactin and suppress the secretion of gonadotropic hormones.

Suppressed libido, depressive mood, low self-esteem, and increased hysteric emotionality are just a few of the prolactin’s negative effects.

Prolactin is in many ways similar to estrogens, its effect is manifested by a decrease in the production of one's own testosterone, a slight increase in fat mass, and, in rare cases, gynecomastia, from which neither Tamoxifen nor Clomid helps.

For this, prolactin inhibitors are used: bromocriptine (an outdated drug with pronounced side effects) or a more modern and safer one – cabergoline.

And now, the highest quality Cabergoline is available under the Driada brand!


Mechanism of action (the boring part)

Cabergoline is a selective dopamine receptor agonist. This drug is highly specific in its actions, with a strong affinity for the dopamine D2 receptor, and a low affinity for dopamine Dl, A 1-adrenergic, A2-adrenergic, 5-HT1- serotonin, and 5-HT2-serotonin receptors. Its main clinical use is for the treatment of hyperprolactinemia, or the hypersecretion of prolactin from lactotropes in the anterior pituitary (pituitary tumor is a common cause of this disorder). It is also applied in the management of Parkinson's disease. Cabergoline effectively inhibits prolactin secretion, which it does by mimicking the actions of dopamine on the D2 receptor (dopamine normally serves as negative feedback for prolactin release). As a targeted agonist of the dopamine D2 receptor, cabergoline should not affect other pituitary hormones like growth hormone (GH), luteinizing hormone (LH), corticotrophin (ACTH), or thyroid-stimulating hormone (TSH).

In addition, interaction with other receptors was established: D3, D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B.


Administration:
  • During the cycle of progestin anabolic steroids (nandrolone, trenbolone) take 0.25 mg every 7-21 days. The optimal dose and frequency of administration is selected under the control of blood tests of the prolactin, since the effect of the drug is different and depends on the individual characteristics of the body. In clinical medicine, this drug may be taken for 6 months or longer
  • When used by athletes/bodybuilders to inhibit prolactin secretion (as with lactating gynecomastia), doses on the lower end of the therapeutic range are most commonly used. although athletes/bodybuilders usually find a 4-6 week course of therapy (combined with an intelligent rearrangement of the offending drugs) most appropriate.
  • When used medically to inhibit prolactin secretion, cabergoline is given in an initial dosage of 500mcg per week. This may be taken in one single dose or divided into 2 or more doses on separate days.
  • With an increase in the level of prolactin above the permissible frequency of administration increases: 0.25 mg, every 4 days. It is advisable to perform a control analysis of prolactin after two doses, followed by a correction of the scheme.

The drug is taken both with food and on an empty stomach.


EFFECTS:

Since the drug is a d-2 dopamine receptor agonist, it has a number of interesting and side effects that would not be correct to call side effects:


  • One of the effects caused by a decrease in prolactin concentration is a decrease in fluid retention in tissues, which leads to an increase in lean muscle mass
  • Reduces the subjective need for sleep
  • Thus, agonist activity specific for D2 subfamily receptors, primarily D2 and D3 receptor subtypes, are the primary targets of dopaminergic antiparkinsonian agents. It is thought that postsynaptic D2 stimulation is primarily responsible for the antiparkinsonian effect of dopamine agonists, while presynaptic D2 stimulation confers neuroprotective effects.
  • The systemic use of cabergoline has been shown to increase glial cell-derived neurotrophic factor (GDNF) expression. GDNF is a small protein that potently promotes the survival of many types of neurons, instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells.[1]

Also there is a list of positive sexual effects( the interesting part):


Effects on libido and sexual performance:

  • Antagonism with α2B receptors additionally explains the positive effect on erectile function (there is an expansion of the cavernous bodies).
  • Cabergoline significantly increases sexual desire both during the cycle and on PCT, enhances orgasm, and reduces recovery time between sexual acts. And in a case of combining it with Viagron you will feel like a teen
  • It is used off-label as a drug for the treatment of antidepressant-related impotence, as well as sexual performance anxiety.


Pharmacodynamics:

The elimination half-life of cabergoline estimated from urinary data of 12 healthy subjects ranged between 63 to 69 hours. The prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.

After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively. Less than 4% of the dose was excreted unchanged in the urine.



Warnings:

• Uncontrolled hypertension or known hypersensitivity to ergot derivatives.

• History of cardiac valvular disorders, as suggested by anatomical evidence of valvulopathy of any valve, determined by pre-treatment evaluation including echocardiographic demonstration of valve leaflet thickening, valve restriction, or mixed valve restriction-stenosis.

• History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.


High dopaminergic activity in the mesolimbic pathway of the brain in a case of overdose may cause hallucinations and delusions, nasal congestion, and syncope.


[1] Cabergoline Decreases Alcohol Drinking and Seeking Behaviors Via Glial Cell Line-Derived Neurotrophic Factor



AND YOU KNOW WHAT???

CABERGOLINE WILL BE AVAILABLE TO ORDER IN OUR SHOP FROM THE NEXT WEEK:p:p
 
I've been using Bayer's Primobolan for years recently I've been trying driada ... the lab tests say no but I have the feeling that driada's is a bit stronger hence my question .. it could also be placebo haha
 
Sterkekoffie1 said:
I've been using Bayer's Primobolan for years recently I've been trying driada ... the lab tests say no but I have the feeling that driada's is a bit stronger hence my question .. it could also be placebo haha
Click to expand...
That's interesting that is I know the tests say something diffeent but I agree I have felt differences before between gear despite tests showing the same results
 
GOOD MORNING, GENTLEMEN! ​

1657697015529.png

Here you can read my small article about it and, probably, know something new.

Driada Medical said:
CABERGOLINE


The main side effects of Nandrolone class steroids (including Trenbolone) are associated with an increase in prolactin levels. Prolactin has the most negative effect on men when it rises in the brain. By binding to the progestin receptors of the pituitary gland, nandrolones increase the production of prolactin and suppress the secretion of gonadotropic hormones.

Suppressed libido, depressive mood, low self-esteem, and increased hysteric emotionality are just a few of the prolactin’s negative effects.

Prolactin is in many ways similar to estrogens, its effect is manifested by a decrease in the production of one's own testosterone, a slight increase in fat mass, and, in rare cases, gynecomastia, from which neither Tamoxifen nor Clomid helps.

For this, prolactin inhibitors are used: bromocriptine (an outdated drug with pronounced side effects) or a more modern and safer one – cabergoline.

And now, the highest quality Cabergoline is available under the Driada brand!


Mechanism of action (the boring part)

Cabergoline is a selective dopamine receptor agonist. This drug is highly specific in its actions, with a strong affinity for the dopamine D2 receptor, and a low affinity for dopamine Dl, A 1-adrenergic, A2-adrenergic, 5-HT1- serotonin, and 5-HT2-serotonin receptors. Its main clinical use is for the treatment of hyperprolactinemia, or the hypersecretion of prolactin from lactotropes in the anterior pituitary (pituitary tumor is a common cause of this disorder). It is also applied in the management of Parkinson's disease. Cabergoline effectively inhibits prolactin secretion, which it does by mimicking the actions of dopamine on the D2 receptor (dopamine normally serves as negative feedback for prolactin release). As a targeted agonist of the dopamine D2 receptor, cabergoline should not affect other pituitary hormones like growth hormone (GH), luteinizing hormone (LH), corticotrophin (ACTH), or thyroid-stimulating hormone (TSH).

In addition, interaction with other receptors was established: D3, D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B.


Administration:
  • During the cycle of progestin anabolic steroids (nandrolone, trenbolone) take 0.25 mg every 7-21 days. The optimal dose and frequency of administration is selected under the control of blood tests of the prolactin, since the effect of the drug is different and depends on the individual characteristics of the body. In clinical medicine, this drug may be taken for 6 months or longer
  • When used by athletes/bodybuilders to inhibit prolactin secretion (as with lactating gynecomastia), doses on the lower end of the therapeutic range are most commonly used. although athletes/bodybuilders usually find a 4-6 week course of therapy (combined with an intelligent rearrangement of the offending drugs) most appropriate.
  • When used medically to inhibit prolactin secretion, cabergoline is given in an initial dosage of 500mcg per week. This may be taken in one single dose or divided into 2 or more doses on separate days.
  • With an increase in the level of prolactin above the permissible frequency of administration increases: 0.25 mg, every 4 days. It is advisable to perform a control analysis of prolactin after two doses, followed by a correction of the scheme.

The drug is taken both with food and on an empty stomach.


EFFECTS:

Since the drug is a d-2 dopamine receptor agonist, it has a number of interesting and side effects that would not be correct to call side effects:


  • One of the effects caused by a decrease in prolactin concentration is a decrease in fluid retention in tissues, which leads to an increase in lean muscle mass
  • Reduces the subjective need for sleep
  • Thus, agonist activity specific for D2 subfamily receptors, primarily D2 and D3 receptor subtypes, are the primary targets of dopaminergic antiparkinsonian agents. It is thought that postsynaptic D2 stimulation is primarily responsible for the antiparkinsonian effect of dopamine agonists, while presynaptic D2 stimulation confers neuroprotective effects.
  • The systemic use of cabergoline has been shown to increase glial cell-derived neurotrophic factor (GDNF) expression. GDNF is a small protein that potently promotes the survival of many types of neurons, instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells.[1]

Also there is a list of positive sexual effects( the interesting part):


Effects on libido and sexual performance:

  • Antagonism with α2B receptors additionally explains the positive effect on erectile function (there is an expansion of the cavernous bodies).
  • Cabergoline significantly increases sexual desire both during the cycle and on PCT, enhances orgasm, and reduces recovery time between sexual acts. And in a case of combining it with Viagron you will feel like a teen
  • It is used off-label as a drug for the treatment of antidepressant-related impotence, as well as sexual performance anxiety.


Pharmacodynamics:

The elimination half-life of cabergoline estimated from urinary data of 12 healthy subjects ranged between 63 to 69 hours. The prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.

After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively. Less than 4% of the dose was excreted unchanged in the urine.



Warnings:

• Uncontrolled hypertension or known hypersensitivity to ergot derivatives.

• History of cardiac valvular disorders, as suggested by anatomical evidence of valvulopathy of any valve, determined by pre-treatment evaluation including echocardiographic demonstration of valve leaflet thickening, valve restriction, or mixed valve restriction-stenosis.

• History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.


High dopaminergic activity in the mesolimbic pathway of the brain in a case of overdose may cause hallucinations and delusions, nasal congestion, and syncope.


[1] Cabergoline Decreases Alcohol Drinking and Seeking Behaviors Via Glial Cell Line-Derived Neurotrophic Factor



AND YOU KNOW WHAT???

CABERGOLINE WILL BE AVAILABLE TO ORDER IN OUR SHOP FROM THE NEXT WEEK:p:p
Click to expand...

BTW, how do you use cabergoline and what is your experience? Share it with us!
 
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