Ecdysteroids: A Novel Class of Anabolic Agents?

[Michael Scally MD]

Chemical structure of ecdysterone (A) as well as of the other anabolic agents used for comparison (B: selective androgen receptor modulator (SARM) S-1, C: anabolic androgenic steroid (AAS) metandienone, D: AAS dihydrotestosterone, E: AAS estradienedione).


Parr MK, Botre F, Nass A, Hengevoss J, Diel P, et al. Ecdysteroids: A novel class of anabolic agents? Biol Sport. 2015;32(2):169-73. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447764/

Increasing numbers of dietary supplements with ecdysteroids are marketed as "natural anabolic agents".

Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of ecdysterone was compared to well characterized anabolic substances. Effects on the fiber sizes of the soleus muscle in rats as well the diameter of C2C12 derived myotubes were used as biological readouts.

Ecdysterone exhibited a strong hypertrophic effect on the fiber size of rat soleus muscle that was found even stronger compared to the test compounds metandienone (dianabol), estradienedione (trenbolox), and SARM S 1, all administered in the same dose (5 mg/kg body weight, for 21 days). In C2C12 myotubes ecdysterone (1 microM) induced a significant increase of the diameter comparable to dihydrotestosterone (1 microM) and IGF 1 (1.3 nM). Molecular docking experiments supported the ERbeta mediated action of ecdysterone.

To clarify its status in sports, ecdysterone should be considered to be included in the class "S1.2 Other Anabolic Agents" of the list of prohibited substances of the World Anti-Doping Agency.

 

[dredd09]

Fascinating read. Stronger response than trenbolone? My interest is Piqued.

 

[Volley_Fire]

I've tried ecdysteroids before. It's hard how much of an effect they had, because I started taking it at the same time as implementing a calorie surplus/bulking diet. I did gain about 10 pounds, probably 7 of which was LBM, in about 6-7 weeks.

Most supplements that contain ecdysteroids are way underdosed and overpriced. You need at least 600-900mg ecdysterone daily. I bought bulk powder and capsuled it up.

 

[ergomaniac]

View attachment 25635

Chemical structure of ecdysterone (A) as well as of the other anabolic agents used for comparison (B: selective androgen receptor modulator (SARM) S-1, C: anabolic androgenic steroid (AAS) metandienone, D: AAS dihydrotestosterone, E: AAS estradienedione).


Parr MK, Botre F, Nass A, Hengevoss J, Diel P, et al. Ecdysteroids: A novel class of anabolic agents? Biol Sport. 2015;32(2):169-73. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447764/

Increasing numbers of dietary supplements with ecdysteroids are marketed as "natural anabolic agents".

Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of ecdysterone was compared to well characterized anabolic substances. Effects on the fiber sizes of the soleus muscle in rats as well the diameter of C2C12 derived myotubes were used as biological readouts.

Ecdysterone exhibited a strong hypertrophic effect on the fiber size of rat soleus muscle that was found even stronger compared to the test compounds metandienone (dianabol), estradienedione (trenbolox), and SARM S 1, all administered in the same dose (5 mg/kg body weight, for 21 days). In C2C12 myotubes ecdysterone (1 microM) induced a significant increase of the diameter comparable to dihydrotestosterone (1 microM) and IGF 1 (1.3 nM). Molecular docking experiments supported the ERbeta mediated action of ecdysterone.

To clarify its status in sports, ecdysterone should be considered to be included in the class "S1.2 Other Anabolic Agents" of the list of prohibited substances of the World Anti-Doping Agency.

interesting. heres a link I was going to put up awhile ago because the studies conclusions are similarly absurd. ergo-log.com/anabolic-effect-ecdysterone-doping-list.html
"our data clearly confirm that ecdysterone is a compound with strong anabolic activity in vivo and in vitro, and that the estradiol receptor beta seems to be involved at least in vitro."
"this opens therapeutic perspectives for treatment of muscle injuries, sarcopenia, and cachectic diseases, but also needs to be considered with respect to classification of ecdysterone as a substance that could be misused for doping purposes." seriously, who are these people?!

anyway, an easy way to get some ecdysteroids is by eating quinoa. apparently, quinoa is bursting with ecdysteroids. ergo-log.com/quinoa.html theres a couple of other links there about ecdysteroids and their positive effects which may include more muscles, less fat, joint repair, and younger skin.
if you eat rice, try switching it with quinoa. they are pretty similar in taste, texture and preparation. another good source is spinach.