Enclomiphene

Discussion in 'Steroid Post Cycle Therapy and ASIH Treatment' started by LittleD90, Nov 12, 2016.

  1. LittleD90

    LittleD90 Member

    Yes they are both SERMs and yes I don't know if I'm allowed to post the site where it's from or not here. Hell no lol that would be the dumbest shit in the world. This is actually my first pct not using rc tbh. I got my hands on some shit from a pharmacy and was stoked seems stronger then before obviously it's correctly dosed lol yea weed makes me a fucking retard.
     
  2. Colt44

    Colt44 Member

    You are probably just not used to accurately dosed Clomid lol. I really don't think it's a great idea to switch mid-pct. I would try lowering the dose for a week and see if that lessens some of the sides. If not, then guinea pig away! Your world though. Let me know how it goes with the enclomiphene if/when you try it.

    At least you are humble enough to admit when a mistake has been made.
     
  3. Spooby

    Spooby Member

    Well for a bit there I was dumbfiunded as to why OP would think switching from pharmacy to RC would be better and less side effect prone? Like... what??? Lol
     
  4. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [LMAO] Repros Announces New CEO
    Repros Announces New CEO

    Repros Therapeutics Inc.® (RPRX) today announced that [CON MAN] Joseph S. Podolski is leaving his position as President and Chief Executive Officer and member of the Board of Directors to pursue other interests.
     
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  5. Megadick3000

    Megadick3000 Member


    No, the switch would not help. Your already taking clomid and getting sides. enclomiphene has the same pharmacophore as clomid. Why would you think it would be any different in the sides department? Curious what your basing that on? From my understanding it would not be any different in that regard.

    Some guys get bad sides from clomid, some dont. You could consider dropping clomid completely and just running tamoxifen. They are both shown to stimulate the HPTA, only tamoxifen seems, at least in anecdotal observations, to cause less of the mental side effcts that clomid causes.

    Alternatively you could just suck it up buttercup :) eventually itll be over with. Keep in mind clomid has a really really long half life, so even if you stopped taking it right this moment you will still have it effecting you for over a month! So dont be heart broken if you do stop taking it today and tomorrow you still feel shitty. Google about its half life and you will understand.

    Goodluck.
     
  6. LittleD90

    LittleD90 Member

    Bruh ur so fuckin late on this lmao!
    Haha go read studies on Enclomiphene before posting your nonsense educate your self fool!
    I always used both tamox and clomid outta here with your school boy shit
    Plus I'm on trt now fuck your clomid tamox pct shit! Coming off is for quitters !
     
  7. Megadick3000

    Megadick3000 Member


    Looks like my buttercup comment got ya butthurt?

    Why would you be on trt? You sound like your 18 years old. Go back to bodybuilding.com "bruh"

    Roflmao lolz lolz :> :> teeheeheehee
     
  8. LittleD90

    LittleD90 Member

    Yup u guessed it!! Haha your probably some stick figure bitch gtfo ass clown
     
  9. Sewnmouth

    Sewnmouth Junior Member

    I'm curious. Did you end up using the enclomiphene and if so how was it? I've been keeping my eye on androxal for years but it seems like it is taking forever to get approved. To me the idea of a single enclomiphene isomer seems great. From what I've gathered it's like getting all the good and none of the bad of clomid.
     
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  10. BirdieNumNum

    BirdieNumNum Member

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  11. LittleD90

    LittleD90 Member

    Never ran it bro so I can't say but I would ditch clomid 100% tamoxifen only maybe throw an otc test booster for mental sides it seems to help
     
  12. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    I am highly doubtful for the ability to obtain Enclomiphene. It is not a simple process for purification.
     
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  13. LittleD90

    LittleD90 Member

    Another reason why I wouldn't use it
    I'm pretty sure the shit I got was just normal clomid
     
  14. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [Worthless Scam] Repros Therapeutics Inc.® Announces Acquisition by Allergan plc [Enclomiphene]
    Repros Therapeutics Inc.® Announces Acquisition by Allergan plc

    THE WOODLANDS, Texas, Dec. 12, 2017 (GLOBE NEWSWIRE) -- Repros Therapeutics Inc. (NASDAQ:RPRX) (“Repros” or the “Company”) today announced that it has entered into a definitive agreement under which Allergan plc (“Allergan”), through a subsidiary, will acquire Repros for a cash payment of $0.67 per share. The Company’s Board of Directors has unanimously approved the transaction.

    Under the terms of the merger agreement, a subsidiary of Allergan will commence a cash tender offer to purchase all of the outstanding shares of Repros common stock for $0.67 per share.
     
  15. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [Worthless] [Scam] Repros Therapeutics Inc.® Receives Feedback Following an Oral Explanation with the European Medicines Agency
    Repros Therapeutics Inc.® Receives Feedback Following an Oral Explanation with the European Medicines Agency (NASDAQ:RPRX)

    THE WOODLANDS, Texas, Dec. 15, 2017 (GLOBE NEWSWIRE) -- Repros Therapeutics Inc. (NASDAQ:RPRX) ("Repros" or the "Company") today announced that following an Oral Explanation, it has received feedback that a negative opinion is likely to be received in January 2018 from the CHMP (Committee for Medicinal Products for Human Use), a committee of the European Medicines Agency (EMA), for the centralized marketing authorization application (MAA) for enclomiphene for the treatment of secondary hypogonadism previously submitted to the EMA by the Company's U.K. subsidiary, Renable Pharma Limited.
     
  16. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Repros Announces Negative Opinion From the EMA for Enclomiphene
    Repros Announces Negative Opinion From the EMA for Enclomiphene | Repros Therapeutics Inc.

    THE WOODLANDS, Texas, Jan. 26, 2018 (GLOBE NEWSWIRE) -- Repros Therapeutics Inc.®, (Nasdaq:RPRX) ("Repros" or the "Company") today announced that, consistent with the previously disclosed guidance from the European Medicines Agency (EMA), the CHMP (Committee for Medicinal Products for Human Use), a committee of the EMA, has formally issued a negative opinion for the centralized marketing authorization application (MAA) for enclomiphene for the treatment of secondary hypogonadism previously submitted to the EMA by the Company's U.K. subsidiary, Renable Pharma Limited.
     
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  17. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [It has always been my opinion that they should have sought FDA Approval for ASIH. Then, off label use would increase sales.]

    Enclomiphene Citrate: A Treatment That Maintains Fertility In Men With Secondary Hypogonadism


    Introduction: Hypogonadism is an important issue among the male population. Treatments such as exogenous testosterone have become very popular. One of the adverse effects of testosterone is its suppression of fertility.

    This has lead to the use of alternative therapies such as selective estrogen receptor modulators (SERMs) that aim to correct hypogonadism without reducing fertility.

    Areas covered: The SERM, clomiphene citrate, which is approved by the FDA for the treatment of ovarian dysfunction, has been shown to have beneficial effects on male hypogonadism. Clomiphene citrate exists as a mixture of both the cis-isomer (zuclomiphene) and the trans-isomer (enclomiphene).

    The literature has suggested that most of the beneficial effects of clomiphene are due to the trans-isomer enclomiphene. Zuclomiphene contributes little to the intended outcomes. The purpose of this drug profile is to examine the available literature on the trans-isomer enclomiphene.

    Expert opinion: Enclomiphene has been shown to increase testosterone levels while stimulating FSH and LH production. Initial studies demonstrated that enclomiphene maintains the androgenic benefit of clomiphene citrate without the undesirable effects attributable to zuclomiphene.

    THIS ARTICLE REVIEWS THE DIFFICULTIES ASSOCIATED WITH THE FDA APPROVAL OF A NEW MOLECULAR ENTITY RELATED TO THE TREATMENT OF HYPOGONADISM.

    Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert review of endocrinology & metabolism 2019:1-9. https://doi.org/10.1080/17446651.2019.1612239
     
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