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Was it the semaglutide itself making you tired or were you eating too little? I've had issues with not eating enough a few times.I got up to 1mg Semaglutide and have switched over to Tirz since the Semaglutide was making me extremely tired. 5mg doesn't seem nearly as effective as the Semaglutide was and I'm guessing it's due to cross tolerance. Anyone have a similar experience?
Hi guys! How do you compare trizepatide vs semaglutide, is it worth to invest x2-x4 the money?
lets say 2.5mg tirzepatide vs 0.2mg sema as initial doses, tiritating up to 15mg weekly vs 2.4mg
The tl;dr is: it depends. Probably Tirz. See below.
Chemically/hormonally they're substantially different. Semaglutide is built on a GLP1-agonist backbone. Tirzepatide is built on a GIP backbone with a side chain that agonizes GLP1 also.
Tirz's structure means hunger suppression is less than Semaglutide -- may not be what you want when doing a simple cut. The GIP agonism instead does stuff to the pancreas around insulin response, which you may want to have to counter developing insulin resistance. And that is what's responsible for its additional efficacy.
So, long and short: it's better, but it also depends on your goals.
I recommend reading the STEP and SURMOUNT trial papers in their entirety, but here's the fun part: the summary graphs.
Note that the dose in the Semaglutide trial is max -- 2.4mg. The dose-response is broken out in the Tirzepatide trial, as they held some people at specific lower doses the entire time.
Lowest dose Tirz = highest dose Sema.
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Curious, but are there any people who are non or light responders to these drugs?
First pin of .25mg was good for me, then I mixed up that and my HGH vial and after that .25 does nothing lol. Did ~.35-.40mg a couple days ago and nothing. Gonna try .5mg in a few days.
I’m also at a reasonable bf and mainly wanting it for the hunger suppression. It’s been tougher than ever since stopping my last blast.
You mixed sema and HGH in the same vial? Wild west territory. May or may not affect solubility of the other peptide, precipitation, bioavailability, probably other variables.
It may be from the half life of the semaglutide doses still in your system.. Check out the GLP-1 Plotter to plug in your dosing strength and duration for sema and you may add in tirz as well.I got up to 1mg Semaglutide and have switched over to Tirz since the Semaglutide was making me extremely tired. 5mg doesn't seem nearly as effective as the Semaglutide was and I'm guessing it's due to cross tolerance. Anyone have a similar experience?
No, I grabbed the sema THINKING it was my HGH. I’ve since marked them more
I honestly think that might be it. I drink a lot of those because I only drink that and water pretty much. I haven’t had one today and guess what? No nasty burps this has to be a big part of it I’m thinking. It sucks too because I love those drinks because they’re very low in sugar and have alll the electrolytes. I guess I’m gonna have to find a new electrolyte source and see if it happens with others or maybe just specifically the gatorlyte. Thanks for the insight
You shouldn't need more... are you stalling?Has anyone used tirz higher than 15mg per week? I’m on 10mg currently but could easily start taking another dose 3-4 days later but this would put me at 20mg for the week overall …
Yes weight just doesn’t seem to be coming off at all anymoreYou shouldn't need more... are you stalling?
time to have a break buddy or re visit your diet and dont rely on the drugs.... i know your a big spender on the GLP's....Yes weight just doesn’t seem to be coming off at all anymore
It sounds like it's up to you now. Being too reliant on the drugsYes weight just doesn’t seem to be coming off at all anymore
More Tirz isn’t going to help you if you’re not overeating. If you’re unwilling to run a steeper deficit or increase cardio, your only other option is to introduce compounds that will burn more calories…Yes weight just doesn’t seem to be coming off at all anymore
time to have a break buddy or re visit your diet and dont rely on the drugs.... i know your a big spender on the GLP's....
It sounds like it's up to you now. Being too reliant on the drugs
More Tirz isn’t going to help you if you’re not overeating. If you’re unwilling to run a steeper deficit or increase cardio, your only other option is to introduce compounds that will burn more calories…
If you’re overeating because Tirzepatide isn’t working anymore, you could take a 3 month break, taking an appetite suppressant like Tesofensine while you allow your GIP and GLP-1 receptors to resensitize.Yes weight just doesn’t seem to be coming off at all anymore
Not many drugs scare me enough to not give them a try if the results they produce are what I’m looking for but Tesofensine concerns me. I really want to try it for the appetite suppression but I’m legit concerned about the seratonin effects and general changes in brain chemistry that are possible.If you’re overeating because Tirzepatide isn’t working anymore, you could take a 3 month break, taking an appetite suppressant like Tesofensine while you allow your GIP and GLP-1 receptors to resensitize.