KBD
New Member
Well someones telling me, Torem will stimulate the Pituitary too much if used with GnRH
MESO-Rx
Anabolic Steroids
GnRH(LHRH) vs Triptorelin Bill Roberts
- Thread starter KBD
- Start date
Well someones telling me, Torem will stimulate the Pituitary too much if used with GnRH
The use of SERM priming (females) has been described with no ill effect. There is NO male literature. And this is in reverse. Further, there is no logic to the claim. GET LABS.
KBD
New Member
Going to get labs, so im not gonna have to worry about being chemically castreated by too much LH stimulation then right? lol just checkin man.
RollinsClone
New Member
From my understanding, the SERM will block estrogen binding to the pituitary, thereby increasing LH by that function.
Now during cycle there is so much test and est that both the hypothalamus and pituitary stop producing gnrh and LH/FSH respectively. So now if you've stopped, and you have no gnrh being pushed, then the tripto will act in this way to bind gnrh receptors on the pituitary and cause it to produce LH/FSH. I believe the SERM should just keep the tripto working properly (due to the increased estrogen in system) and not cause an excess of LH to be produced. Then again, I don't see why if you've been shutdown this long Estrogen would be really that high. But like Dr. Scally has stated, you need lab results to confirm any of this, otherwise we could guess and hypothesize as to whats going on and try and gather completely subjective evidence such as "I feel a burst of energy there for levels x, y, z must be high).
Dr. Scally is estrogen usually greatly elevated when having been on testosterone (say a trt dose of 100-200mg a week) or is it usually restricted to heavy androgen use/ other factors
jasthace
New Member
Got an update on this KBD please
See: https://thinksteroids.com/community/posts/772184
I will ask KBD to post the results. IMO, they are very good and promising for HPTA functionality. [Note: hCG, NOT GnRH, was useful.]
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jtmoy19607
New Member
is there anyway to get actual gnrh as pump?
Triptorelin acetate would serve the same purpose I think just as well and is more practical.
That said, take a look at these results: Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study
As measured from the time period only 5 days after starting treatment and then for about the next two weeks, LH area under the curve was decreased from even only 15 mcg/day!
So it would be counterproductive to use this drug at even that dose on a chronic basis.
Whatever use there is is either from very brief usage, even single dose and at a modest dose; or if there can be value to chronic usage, it would have to be at a dose well below 15 mcg/day.
That said, take a look at these results: Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study
As measured from the time period only 5 days after starting treatment and then for about the next two weeks, LH area under the curve was decreased from even only 15 mcg/day!
So it would be counterproductive to use this drug at even that dose on a chronic basis.
Whatever use there is is either from very brief usage, even single dose and at a modest dose; or if there can be value to chronic usage, it would have to be at a dose well below 15 mcg/day.
jtmoy19607
New Member
so what dosage is good for Triptorelin? doesn't it eventually create a negative feedback, due to the male body only handling gnrh in pulsating ways?
Not just eventually, but fairly rapidly.
I've never used it nor worked with anyone using it. Others who have used it have suggested using a single injection only. Unfortunately I'm unable to comment beyond what they said themselves, other than that the single injection idea seems unlikely to harm and certainly stranger things have happened than something like this working, and there are positive reports.
Based on dose/response being such that even 5 days of use at 15 mcg/day has a net suppressive effect, I'd tend to expect that the single injection may not need to be past even 15 mcg. However the reported experiments were at higher doses than that.
I've never used it nor worked with anyone using it. Others who have used it have suggested using a single injection only. Unfortunately I'm unable to comment beyond what they said themselves, other than that the single injection idea seems unlikely to harm and certainly stranger things have happened than something like this working, and there are positive reports.
Based on dose/response being such that even 5 days of use at 15 mcg/day has a net suppressive effect, I'd tend to expect that the single injection may not need to be past even 15 mcg. However the reported experiments were at higher doses than that.
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