Hair Loss

[Michael Scally MD]

[OA] Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens-such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)-are the key factors in terminal hair growth.

They act on sex-specific areas of the body, converting small, straight, fair vellus hairs into larger darker terminal hairs. They bind to intracellular androgen receptors in the dermal papilla cells of the hair follicle. The majority of hair follicles also require the intracellular enzyme 5-alpha reductase to convert testosterone into DHT.

Apart from androgens, the role of other hormones is also currently being researched-e.g., estradiol can significantly alter the hair follicle growth and cycle by binding to estrogen receptors and influencing aromatase activity, which is responsible for converting androgen into estrogen (E2).

Progesterone, at the level of the hair follicle, decreases the conversion of testosterone into DHT. The influence of prolactin (PRL) on hair growth has also been intensively investigated, and PRL and PRL receptors were detected in human scalp skin.

Our review includes results from many analyses and provides a comprehensive up-to-date understanding of the subject of the effects of hormonal changes on the hair follicle.

Grymowicz M, Rudnicka E, Podfigurna A, et al. Hormonal Effects on Hair Follicles. Int J Mol Sci. 2020;21(15):E5342. Published 2020 Jul 28. doi:10.3390/ijms21155342 https://www.mdpi.com/1422-0067/21/15/5342/htm

 

[Michael Scally MD]

Analysis of YouTube hair loss treatment information: what makes for engaging content?

Objective: Patients are increasingly seeking effective hair loss treatments. The internet and social media are popular sources of health information, but the quality and reliability of the content available to patients is highly variable. More than two thirds of American adults reported using YouTube in 2019. We investigated public interest in hair loss treatment information on YouTube and evaluated the quality of health information in videos with high viewer engagement.

Methods: In July 2020, we used Google Trends, limited to YouTube searches, to analyze relative interest in hair loss treatments worldwide. We searched YouTube using non-surgical and surgical hair loss treatment terms and we analyzed the retrieved video content. The DISCERN tool was used to evaluate the quality of health information in the hair loss treatment videos with highest viewer engagement.

Results: There is increasing public interest in YouTube searches for hair loss treatments. A large number of hair loss treatment videos are available on YouTube, but potential patients are likely to access mostly new content created by well-subscribed channels. Videos with high viewer engagement contain information that can be useful in guiding treatment decisions, but tend to be biased because they are intended to promote dermatology and hair restoration clinics.

Conclusions: Patients are using YouTube as a source of hair loss treatment information. Videos created by hair restoration experts contain reliable information, but their quality can be improved by providing links to other sources.

Gupta AK, Ivanova IA. Analysis of YouTube hair loss treatment information: what makes for engaging content? [published online ahead of print, 2020 Aug 29]. Dermatol Ther. 2020;10.1111/dth.14244. doi:10.1111/dth.14244 Error - Cookies Turned Off

 

[Michael Scally MD]

Aromatase Inhibitor-Induced Hair Loss In Two Adolescents

Hair loss and thinning are possible complications in those undergoing endocrine therapies with aromatase inhibitors. Alopecia in pediatric patients undergoing endocrine therapy has not been previously reported.

We describe two adolescents, 14 and 16 years of age, who developed androgenetic alopecia following treatment with anastrozole for idiopathic short stature. Accordingly, the possible adverse event of alopecia should be considered in the pediatric population undergoing treatment with aromatase inhibitors.

Perper M, Herskovitz I, Tosti A. Aromatase inhibitor-induced hair loss in two adolescents [published online ahead of print, 2020 Sep 1]. Pediatr Dermatol. 2020;10.1111/pde.14339. doi:10.1111/pde.14339 Error - Cookies Turned Off

 

[Michael Scally MD]

Implications of Cigarette Smoking on Early Onset Androgenetic Alopecia

Androgenetic alopecia (AGA) is a condition affecting both males and females. We aimed to asses the demographic and clinical features of early-onset AGA among smokers and non smokers and to evaluate if prevalence of AGA was affected by smoking.

One thousand (1000) healthy males aged between 20-35 years not complaining of any local scalp condition and free of any mental illness were recruited for this study and divided into two groups of 500 each based on their smoking attitudes. Androgentic alopecia was classified according to the Hamilton baldness scale, and trichoscopy was used to confirm the diagnosis of AGA. A designed questionnaire to determine basic physical and smoking habits completed and results were interpreted and analysed.

The majority of smokers (425) had a form of AGA, while only (200) non smokers had a degree of AGA (P<0.01). Of the smokers group 235(47%) had grade III AGA and 120 subjects (24%) had grade IV AGA. In the non-smokers group 100 subjects (20%) had grade II AGA and 50 subjects (10%) had either grade III or IV AGA.

The prevalence of AGA among smokers was statistically higher than among non smokers while severity of AGA was not associated to the intensity of smoking. Nicotine and its derivative cotinine might be resposnsible for accelarting AGA progress pending further validation.

Salem AS, Ibrahim HS, Abdelaziz HH, Elsaie ML. Implications of Cigarette Smoking on Early Onset Androgenetic Alopecia: A Cross Sectional Study [published online ahead of print, 2020 Sep 18]. J Cosmet Dermatol. 2020;10.1111/jocd.13727. doi:10.1111/jocd.13727 Error - Cookies Turned Off

 

[Michael Scally MD]

[OA] Hormonal Regulation in Male Androgenetic Alopecia-Sex Hormones and Beyond: Evidence from Recent Genetic Studies

Male-pattern hair loss, also termed androgenetic alopecia (AGA), is a highly prevalent age-related condition that is characterized by a distinct pattern of hair loss from the frontotemporal and vertex regions of the scalp.

The phenotype is highly heritable and hormone dependent, with androgens being the recognized critical hormonal factor. Numerous molecular genetic studies have focused on genetic variation in and around the gene that encodes the androgen receptor.

More recently, however, the availability of high-throughput molecular genetic methods, novel methods of data analysis and sufficiently large sample sizes have rendered possible the systematic investigation of the contribution of other components of the androgen receptor pathway or hormonal pathways beyond the androgen receptor signalling pathways.

Over the past decade, genome-wide association studies of increasingly large cohorts have enabled the genome-wide identification of genetic risk factors for AGA, and yielded unprecedented insights into the underlying pathobiology.

The present review discusses some of the most intriguing genetic findings on the relevance of (sex)hormonal signalling in AGA.

Heilmann-Heimbach S, Hochfeld LM, Henne SK, Nöthen MM. Hormonal regulation in male androgenetic alopecia-Sex hormones and beyond: Evidence from recent genetic studies [published online ahead of print, 2020 Jun 17]. Exp Dermatol. 2020;10.1111/exd.14130. doi:10.1111/exd.14130 Error - Cookies Turned Off

 

[rand0m]

End of September, End of Minox. Fuck it. Didn't saw any thing.

Started with 2% and pretty much in 2 or 3 weeks, saw some changes and little dudes popping out. Researched and learned that they wont grow, ever.

No change in density. Seems like I have thinned out more.

Taking a bath everyday is literally needed. I was getting more concerned about the fucking solid white flakes that took some serious force to wipe off if you skipped taking bath or applying freaking shampoo ONE day! Fuck! Fine with balding, not with "you look like you are homeless dirty pos".

Experiment failed.

I am mentally free now. Fuck this.

 

[Songoku06]

what is the steroid is the most dangerous for hair loss and dangerous order ?

 

[MythotiK]

what is the steroid is the most dangerous for hair loss and dangerous order ?

Masteron.

 

[Songoku06]

- winstrol
- masteron
- anadrol
- dianabol
- trenbolone
- testo
- eq
- deca
- anavar

 

[Rodney Williams]

Great post bro, that is one of my biggest fears like most of us thanks for posting this article

 

[TheNewf]

Any guys in here have any success with ru58841?

 

[TheNewf]

End of September, End of Minox. Fuck it. Didn't saw any thing.

Started with 2% and pretty much in 2 or 3 weeks, saw some changes and little dudes popping out. Researched and learned that they wont grow, ever.

No change in density. Seems like I have thinned out more.

Taking a bath everyday is literally needed. I was getting more concerned about the fucking solid white flakes that took some serious force to wipe off if you skipped taking bath or applying freaking shampoo ONE day! Fuck! Fine with balding, not with "you look like you are homeless dirty pos".

Experiment failed.

I am mentally free now. Fuck this.

2 percent is practically useless. Nobody should use 2 over 5 percent. Minox is something you really have to stick to long term to see any improvement. Also way more success rate if you combine dermarolling/dermaneedling with minoxidil. Those baby hairs can turn terminal with the right protocol

also might be worth your time taking fin or dutasteride Before giving up if you aren’t blasting any other roids besides test.

 

[Michael Scally MD]

Bigby M, Grimalt R. Platelet-rich plasma lacks evidence of clinically significant improvement in androgenetic alopecia. J Am Acad Dermatol. 2020 Nov 27:S0190-9622(20)33063-2. doi: 10.1016/j.jaad.2020.02.088. Epub ahead of print. PMID: 33253851. https://www.jaad.org/article/S0190-9622(20)33063-2/pdf


Hooper D. Platelet rich plasma has a place in the treatment of androgenetic alopecia. J Am Acad Dermatol. 2020 Nov 27:S0190-9622(20)33064-4. doi: 10.1016/j.jaad.2020.11.030. Epub ahead of print. PMID: 33253835. https://www.jaad.org/article/S0190-9622(20)33064-4/pdf


Sanabria B, de Nardo Vanzela T, Miot HA, Ramos PM. Adverse Effects of Low-dose Oral Minoxidil for Androgenetic Alopecia in 435 patients. J Am Acad Dermatol. 2020 Nov 27:S0190-9622(20)33074-7. doi: 10.1016/j.jaad.2020.11.035. Epub ahead of print. PMID: 33253848. https://www.jaad.org/article/S0190-9622(20)33074-7/pdf

 

[CaterpillarTom]

As a newbie definitely something that is always on my mind - I haven't lost any yet but its probably speeding up the process. Receding hairline is so bad that I decided to trim it short anyway so fuq it.

 

[Qwert]

I've been cycling since 24, & after my early 30s, my hair loss accelerated at a rapid pace.

Since I was never going to go off forever, I did some serious research & experiments on myself & finally found a regime that has stopped my hair loss & reversed it to the point of having an acceptable hairline, even when on 1.5g of gear.

Here is my daily program:

5% Nizoral lathered into my hair & left on for 30 mins before showering in the AM
5% Minoxidil foam 2x a day
50mg RU58841 2x daily
.5mg Dutasteride 2x daily

I recently found a good sourrce for Minox 10% in India & have ordered it.

 

[TideGear]

I've been cycling since 24, & after my early 30s, my hair loss accelerated at a rapid pace.

Since I was never going to go off forever, I did some serious research & experiments on myself & finally found a regime that has stopped my hair loss & reversed it to the point of having an acceptable hairline, even when on 1.5g of gear.

Here is my daily program:

5% Nizoral lathered into my hair & left on for 30 mins before showering in the AM
5% Minoxidil foam 2x a day
50mg RU58841 2x daily
.5mg Dutasteride 2x daily

I recently found a good sourrce for Minox 10% in India & have ordered it.

I was recently prescribed oral minoxidil in addition to dutasteride. 9 months in on dutasteride and still slowly losing. Curious to see if the oral minoxidil will change anything.

 

[Qwert]

I was recently prescribed oral minoxidil in addition to dutasteride. 9 months in on dutasteride and still slowly losing. Curious to see if the oral minoxidil will change anything.

How much Dutasteride are you taking? I only started to see anything significant when taking 1mg a day.

I tried oral Minoxidil years ago. It worked alright, but it grew hair all over my body, including my forehead, so I stopped. I can deal with extra body hair, but forehead hair is not acceptable.

 

[TideGear]

How much Dutasteride are you taking? I only started to see anything significant when taking 1mg a day.

I tried oral Minoxidil years ago. It worked alright, but it grew hair all over my body, including my forehead, so I stopped. I can deal with extra body hair, but forehead hair is not acceptable.

.5

 

[Michael Scally MD]

Artificial Hair Implantation for Hair Restoration

Background: Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women. Artificial hair implantation is considered an alternative treatment when the donor area is depleted or unsuitable for hair transplantation. The use of artificial hair implants remains controversial, particularly because this practice has been banned by the US FDA.

Objective: To summarize various aspects of artificial hair implantation.

Methods: We discuss the history of artificial hair implantation, development of new biocompatible fibers (Biofibre®, Nido Z-type), patient eligibility for this treatment, implantation technique, follow-up, immune response to the implanted fibers, and post-implantation complications. We performed a methodological quality assessment of the clinical studies that investigated artificial hair implantation using the Canada Institute of Health Economics (IHE) Quality Appraisal Tool for Case Series (Interventional).

Results: Although the studies evaluating the use of artificial hair fibers appear promising, the methodological quality of most of them was "poor" and "fair", due to lack of randomization, absence of control groups, improper study design and inappropriate outcome measures.

Conclusions: Artificial hair implantation has been received with skepticism among physicians due to the complications reported. Further high-quality research needs to be performed to ascertain the safety and efficacy of artificial hair implantation.

Gupta AK, Venkataraman M, Quinlan EM. Artificial hair implantation for hair restoration. J Dermatolog Treat. 2021 Feb 10:1-22. doi: 10.1080/09546634.2021.1887442. Epub ahead of print. PMID: 33565339. https://www.tandfonline.com/doi/full/10.1080/09546634.2021.1887442

 

[Michael Scally MD]

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