To update you a few weeks on, I saw immediate and much better improvement from adding the topical minox and finasteride and have since stopped the pyrilutamide for the time being. The minox is what is making the biggest impact i think, because I can see regrowth on the areas I'm rubbing it. I stopped pyril probably 3/4 weeks ago and the improvements have continued.
Perhaps it was a lag and the pyril took some time to work, but the difference has been drastic with minox/fina and instant - so from now on I'll be sticking with those two and not pyril. Also, I use ketaconazole 3x per week and a Piroctone olamine shampoo as well.
If the effect drops off over the next few months, I'll assume the pyril was actually working but it was delayed impact and come back to update here.