Helping a 350lb friend

I would completely forget about drugs and focus on diet, training and a lot of cardio.. Take your time to learn..
Once these are nailed in he will have lost 80-100lbs anyway, then can start finer tweaking to get down even further, again by this time he will have built a solid base of muscle underneath and good ideology of training and what works best for him..

I would take this opportunity to get down to at least 12%-15% before even worrying about what the muscles are looking like.. Once at this Body fat he can either employ a mass routine or start a lean bulk.. This will be a long process but you will see the package start coming together within 6 months if done correctly..

Seriously my friend.. Your friend does not need any type of performance enhancing drug.. I'm going to guess that he come from a pretty unhealthy background so think about state of internal organs already.. These need a big break while he loses weight and takes even more stress off them..
 
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