High Responder: T >15ng/dL, E2 90, Hct 51.8% | Crashing on Taper | Need Protocol Advice

What was your blasting mg?

Would you be willing to do the following tests on the same day?
- cystain c
- creatinine
- urine ACR

If you do we can plug it into a proper kidney calculator and see what's going on.

What's your training look like? Are you doing the main compound movements?
Drifted away from some compounds and am pretty much following Milo Wolf Myoadapt app. I sure would be happy to do the test on the same day and share. btw I am still waiting (next few days) for results of:
  • IGF-1 (Somatomedin C)
  • Zinc
  • Homocysteine
  • Free Testosterone
  • SHBG
 
Drifted away from some compounds and am pretty much following Milo Wolf Myoadapt app. I sure would be happy to do the test on the same day and share. btw I am still waiting (next few days) for results of:
  • IGF-1 (Somatomedin C)
  • Zinc
  • Homocysteine
  • Free Testosterone
  • SHBG
First ever dose was 250mg/week for 10 weeks. After a 2-month break, I blasted 500mg Test/500mg Deca for 5 weeks, then cruise/and nothing for 6 months then followed by a 6-week run of 250mg Test, 200mg Primo, and 10mg Anavar.and now pretty much 187mg test C for last 6 months.
 
First ever dose was 250mg/week for 10 weeks. After a 2-month break, I blasted 500mg Test/500mg Deca for 5 weeks, then cruise/and nothing for 6 months then followed by a 6-week run of 250mg Test, 200mg Primo, and 10mg Anavar.and now pretty much 187mg test C for last 6 months.
In 5 weeks you didn't even reach peak concentration.

2 month break was only a few weeks off because the compounds were still active after 6 weeks. No wonder why you feel crappy.

You need to fix up your vitamin D3 and folate.

Learn how to train and eat. Are you taking any ancillaries? Like blood pressure meds etc
 
I recommend reading through some workout logs:

Thread 'My journey from permabulk to get jacked'

Thread 'Daily Log to 2019 Show Season'

Thread 'Long Off-Season to Classic D Class Weight Cap'

There are others but these are the ones I remember.
 
In 5 weeks you didn't even reach peak concentration.

2 month break was only a few weeks off because the compounds were still active after 6 weeks. No wonder why you feel crappy.

You need to fix up your vitamin D3 and folate.

Learn how to train and eat. Are you taking any ancillaries? Like blood pressure meds etc

You can tell I don’t really know where to start in terms of getting the right information. Apart from omega-3, magnesium, creatine and ashwagandha, I’ve only just started taking vitamin D. I’m not taking anything for blood pressure.
 
You can tell I don’t really know where to start in terms of getting the right information. Apart from omega-3, magnesium, creatine and ashwagandha, I’ve only just started taking vitamin D. I’m not taking anything for blood pressure.
Telmisartan is the gold standard for kidney protection .

There is lots of good info here.

You only need 125-150mg per week and a good training program like starting strength.

You can build a good base of strength first then the steroids will work better.

There is a book called "the barbell prescription" by Mark Rippetoe. It's programming for older gentleman.
 
I recommend reading through some workout logs:

Thread 'My journey from permabulk to get jacked'

Thread 'Daily Log to 2019 Show Season'

Thread 'Long Off-Season to Classic D Class Weight Cap'

There are others but these are the ones I remember.
Fantastic.
 
Telmisartan is the gold standard for kidney protection .

There is lots of good info here.

You only need 125-150mg per week and a good training program like starting strength.

You can build a good base of strength first then the steroids will work better.

There is a book called "the barbell prescription" by Mark Rippetoe. It's programming for older gentleman.

Telmisartan is the gold standard for kidney protection .

There is lots of good info here.

You only need 125-150mg per week and a good training program like starting strength.

You can build a good base of strength first then the steroids will work better.

There is a book called "the barbell prescription" by Mark Rippetoe. It's programming for older gentleman.
Thanks — really appreciate it. Great forum, and people like you make it easy for newcomers like me.
 
I appreciate the input, and I agree. Just to clarify: I started at a low 2.50 ng/mL baseline, which led to 250mg/week for 10 weeks. After a 2-month break, I blasted 500mg Test/500mg Deca for 5 weeks, followed by a 6-week run of 250mg Test, 200mg Primo, and 10mg Anavar.

I’m chasing an athletic build, not a bodybuilder's stage weight. My training is focused on circuits and resistance, and I’ll be the first to admit my diet discipline hasn't been 100% 'ripped' status yet.

The bottom line: I want to move to a standard TRT dose without the crash. What’s the move? Is 100–120mg cold turkey the right call, or is there a way to do it while being able to get some gains?
I'd guess 19-20. No vascularity, no visible abs or striations anywhere really. I'm not sure where you started but you definitely don't have much to show for someone who has been "blasting and cruising" for 2 years. Stay at TRT until you get your training and diet figured out as something is clearly off there. If I saw you in the gym I would never guess you were on anything.

You're only screwing yourself harder with PEDs. The trade off is supposed to be that you get some bad health markers in exchange for muscularity and looking ripped. You seem to not be getting the reward portion of the deal.
 
I appreciate the input, and I agree. Just to clarify: I started at a low 2.50 ng/mL baseline, which led to 250mg/week for 10 weeks. After a 2-month break, I blasted 500mg Test/500mg Deca for 5 weeks, followed by a 6-week run of 250mg Test, 200mg Primo, and 10mg Anavar.

I’m chasing an athletic build, not a bodybuilder's stage weight. My training is focused on circuits and resistance, and I’ll be the first to admit my diet discipline hasn't been 100% 'ripped' status yet.

The bottom line: I want to move to a standard TRT dose without the crash. What’s the move? Is 100–120mg cold turkey the right call, or is there a way to do it while being able to get some gains?
You're gonna have to get strong to get big bro.

You're gonna have to practise explosive movements like the power clean to maintain Type 2 fibres. They atrophy with age. You're gonna have to lift heavy weights with compound movements.

All these things hurt and are hard. Doing circuits ain't gonna grow any muscle. Unless you're one of those guys who fart on steroids and grow muscle.

If you want to do yoga or whatever just stay on TRT. Steroids will actually make your performance worse.
 
I’m chasing an athletic build, not a bodybuilder's stage weight.

Then you don't need to blast at all. TRT levels will achieve that up to your genetic potential. You just need to learn how to trigger the appropriate pathways for growth. And stay on top of your cardio. Keep calories in a moderate surpluse (200 ish)

Is 100–120mg cold turkey the right call, or is there a way to do it while being able to get some gains?

There's no one-size-fits-all dose but the range is about right. You need to first get saturated at your chosen dose then pull your total T and free T. This will tell you if you need to go up or down. You will make gains on a TRT dose if your diet and training are dialed in.
 
Stats
Age: 53
Weight: 84.5 kg
Body Fat: 22% (approximate)

History: Various blasts and cruises over the last 2 years. Stable on this current dose (~187mg/wk) for the last 6 months.

Current Protocol: 187.5 mg/week (Test C 250mg/mL) split into 3 injections.

Lifestyle: 2–4 hours training/week.
Not best diet (protein and fibre solid but still too much sugar, fat, salt, and refined carbs).
Chronic dehydration (under 1 liter of water per day).

The Context (Mental Health and Baseline)
I have been using this higher dose as a quick hack to stay on top of mounting personal stress and pressure. The Test has definitely helped my libido and drive stay alive during a very dark period where I feared a depressive slide.

My natural baseline (pre-TRT) was very poor:
Free T: 14.1 pmol/L (Below reference range)
SHBG: 47 nmol/L

Because my GP has zero experience with TRT, I have been navigating this on my own.
Given my 2-year history of blasting and cruising, I believe my neurochemistry is heavily adapted to high androgen levels, which is likely why my previous attempts to taper felt so brutal.

The Problem
I am a massive high-responder. At 187.5mg/week, my levels are pinned at >15ng/mL. When I previously tried to taper by 20% (down to 150mg/week), I crashed hard—specifically libido and mental well-being—though my gym performance stayed decent. I want to get healthy and bring these markers down, but I am looking for a way to avoid that depressive hole.

Latest Lab Results (Feb 2026)

Total Testosterone: >15.00 ng/mL (Ref: 1.93 – 7.40)

Estradiol (E2): 90.0 pg/mL (Ref: 11.3 – 43.2)

Hematocrit: 51.8% (Ref max: 48.6%)

eGFR (Kidney): 67 mL/min (Ref: >90)

Creatinine: 12.2 mg/L (Ref max: 11.7)

HOMA-IR: 2.34 (Rising insulin resistance)

Vitamin D: 28.3 (Low)

Folate (B9): 2.9 (Critically Low)

Questions for the Forum

1. The Crash: Was the previous crash likely due to the T:E2 ratio shifting too fast after 2 years of being enhanced? How do I drop dose without the mental and libido side effects?

2. E2 Management: At 90 pg/mL, should I use a micro-dose AI (0.125mg) while I slowly lower the Test dose to stabilize the transition?

3. Health Priority: With an eGFR of 67 and Hematocrit of 51.8 after 2 years of B&C, how urgent is this? Will 4L of water and lower salt pull these back, or do I need a phlebotomy?

4. Nutritional Link: Should I fix the Folate and Vitamin D first to stabilize my mood before I touch the Testosterone dose?

5. The Micro-Taper: Has anyone successfully used very small drops (e.g., 5-10mg a week) to get off a cruise without the brain noticing the dip?

I am trying to move away from using TRT as a crutch for stress, but I need a sustainable exit strategy. I have nowhere else to go for advice other than this forum as a starting point.

I appreciate any experience you guys can share. I need to get off the "stress-crutch" without falling apart.

The problem is most likely psychosomatic.

I have played your game for way longer than you have.

The best I have ever felt and all of my health markers have been great and I was just as strong is

50mg Test cyp + 500iu HCG e3.5D the END

If you cycle when you are done you just got right back to this OR YOU DO AN HCG RESET

an HCG reset to you stop everything but HCG at 1000iu MWF and do that for 4 weeks then you go to TRT at 50mg test cyp + 500iu HCG e3.5D
 
I’m not an expert, but wanted to mention this vitamin. Folate deficiency very often coincides with poorer cardiovascular health, because of its effects on endothelial function and homocysteine. I’m not sure if you’ve looked, but low folate has a direct link to depression and poor mental health. Since you mentioned thyroid, it impacts that also.

My husband has a family history of CVD, and this is one of the supplements I put him on. The folate is an active form that bypasses any possible conversion dysfunction due to genetic mutations. It also has all the cofactors needed. If you tolerate once daily dosing, then you can try twice daily for more folate exposure then taper, and it will replenish your levels sooner. I’d recheck levels at 6-8 weeks. It doesn’t have to be this one, just giving you a jumping point.

Do you have any gut dysfunction? Folate deficiency isn’t common, wondering if there’s an absorption issue. If not, it’s most likely dietary or alcohol related. I also saw you mention thyroid which often goes along with gastro issues.

Last thing, I may have missed it, but I have higher shbg and dosing eod helps with stability and symptoms when making dose adjustments.

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