MESO-Rx

Anabolic Steroids

how to make transdermal testosterone?

KingDHT said:
I am also interested in taking testosterone in dmso for TRT because i find it extremely simple and easy to integrate in a daily routine

The problem with testosterone base in dmso is it hits you very hard and very fast but the effects do not last long. So you need to apply it 2-3 times per day. This method also has a major problem: it loses some power over time, likely because of repeating extreme stimulation of the dopamine system caused by sudden and brief sky high testosterone levels. This probably cause some dopamine desensitization over time.

remember guys, men only produces a total of around 3-9mg of test through an entire day.

with testosterone in dmso, it's dozens of mg absorbed in a matter of minutes ! I dont think it's very natural. Testosterone TNE and suspension are also pure testosterone but the absorption is slower because of the oil and crystals. With dmso its straight to the blood in minutes.

we are interested in trying testosterone acetate in dmso for a steady level of test through the day. It seems acetate ester is soluble in dmso, a lot of guys used trenbolone acetate from implant pellets (Finaplix) in dmso back in the days. I just hope the ester can pass the skin because it will be live changing for TRT
Click to expand...
Just ordered testosterone acetate thanks to you and will let you know what its solubility is in DMSO.
Imagine just having to put a few drops of DMSO every morning on your balls or shoulders to achieve 3000-5000ng/dl.

Will obviously draw bloods after 15 days of continuous use.
 
Goingstronger said:
Just ordered testosterone acetate thanks to you and will let you know what its solubility is in DMSO.
Imagine just having to put a few drops of DMSO every morning on your balls or shoulders to achieve 3000-5000ng/dl.

Will obviously draw bloods after 15 days of continuous use.
Click to expand...
Truely a game changer if it works
 
Goingstronger said:
Just ordered testosterone acetate thanks to you and will let you know what its solubility is in DMSO.
Imagine just having to put a few drops of DMSO every morning on your balls or shoulders to achieve 3000-5000ng/dl.

Will obviously draw bloods after 15 days of continuous use.
Click to expand...
Interesting experiment. Looking forward to your results.
 
Alright I also just ordered some acetate and tne. I would like to try this as well. I’m going to use bass killers recipe for the most part. DMSO, IPA and prop glycol.
 
JoMamma69 said:
Alright I also just ordered some acetate and tne. I would like to try this as well. I’m going to use bass killers recipe for the most part. DMSO, IPA and prop glycol.
Click to expand...
I have a super easy and effective recipe. 1% azone and just use ethanol as the solution and to dissolve the Raws. Azone is the best skin penetrator
 
This is the first I have heard of azone. So 1% azone, the rest ethanol?

It looks like azone is a mix of dmso for the most part. Do you have personal experience with this?
 
Goingstronger said:
Just ordered testosterone acetate thanks to you and will let you know what its solubility is in DMSO.
Imagine just having to put a few drops of DMSO every morning on your balls or shoulders to achieve 3000-5000ng/dl.

Will obviously draw bloods after 15 days of continuous use.
Click to expand...


Do note bro, i investigated transdermal testosterone ESTERS and the data i saw indicated practically all the ester is lost during transdermal penetration of the skin. This is not to say the testosterone did not absorb, but rather during the absorption process the esterification was lost and more or less it just became testosterone freebase by the time it reached the blood stream.

I dont recall off the top of my head what esters they had studied. Let me see if i can locate the stidy i had read.

Skin permeation of testosterone and its ester derivatives in rats​

M K Kim 1, C H Lee, D D Kim
Affiliations expand

Abstract​

To establish the optimum conditions for improving the transdermal delivery of testosterone, we studied the relationship between the lipophilicity of testosterone ester derivatives and the rat skin permeation rate of testosterone. We performed a rat skin permeation study of testosterone and its commercially available ester derivatives, testosterone hemisuccinate, testosterone propionate and testosterone-17beta-cypionate, using an ethanol/water co-solvent system. The aqueous solubility and rat skin permeation rate of each drug, saturated in various compositions of an ethanol/water system, was determined at 37 degrees C. The aqueous solubility of testosterone and its ester derivatives increased exponentially as the volume fraction of ethanol increased up to 100% (v/v). The stability of testosterone propionate in both the skin homogenate and the extract was investigated to observe the enzymatic degradation during the skin permeation process. Testosterone propionate was found to be stable in the isotonic buffer solution and in the epidermis-side extract for 10h at 37 degrees C. However, in the skin homogenate and the dermis-side extract testosterone propionate rapidly degraded producing testosterone, implying that testosterone propionate rapidly degraded to testosterone during the skin permeation process. The steady-state permeation rates of testosterone in the ethanol/water systems increased exponentially as the volume fraction of ethanol increased, reaching the maximum value (2.69+/-0.69 microg cm(-2)h(-1)) at 70% (v/v) ethanol in water, and then decreasing with further increases in the ethanol volume fraction. However, in the skin permeation study with testosterone esters saturated in 70% (v/v) ethanol in water system, testosterone esters were hardly detected in the receptor solution, probably due to the rapid degradation to testosterone during the skin permeation process. Moreover, a parabolic relationship was observed between the permeation rate of testosterone and the log P values of ester derivatives. Maximum flux was achieved at a log P value of around 3 which corresponded to that of testosterone (log P = 3.4). The results showed that the skin permeation rate of testosterone and its ester derivatives was maximized when these compounds were saturated in a 70% ethanolic solution. It was also found that a log P value of around 3 is suitable for the skin permeation of testosterone related compounds.



Its possible i am misinterpreting this data, but it seems to indicate esters are degraded into their freebase during transdermal absorption.
 
Megadick3000 said:
Do note bro, i investigated transdermal testosterone ESTERS and the data i saw indicated practically all the ester is lost during transdermal penetration of the skin. This is not to say the testosterone did not absorb, but rather during the absorption process the esterification was lost and more or less it just became testosterone freebase by the time it reached the blood stream.

I dont recall off the top of my head what esters they had studied. Let me see if i can locate the stidy i had read.

Skin permeation of testosterone and its ester derivatives in rats​

M K Kim 1, C H Lee, D D Kim
Affiliations expand

Abstract​

To establish the optimum conditions for improving the transdermal delivery of testosterone, we studied the relationship between the lipophilicity of testosterone ester derivatives and the rat skin permeation rate of testosterone. We performed a rat skin permeation study of testosterone and its commercially available ester derivatives, testosterone hemisuccinate, testosterone propionate and testosterone-17beta-cypionate, using an ethanol/water co-solvent system. The aqueous solubility and rat skin permeation rate of each drug, saturated in various compositions of an ethanol/water system, was determined at 37 degrees C. The aqueous solubility of testosterone and its ester derivatives increased exponentially as the volume fraction of ethanol increased up to 100% (v/v). The stability of testosterone propionate in both the skin homogenate and the extract was investigated to observe the enzymatic degradation during the skin permeation process. Testosterone propionate was found to be stable in the isotonic buffer solution and in the epidermis-side extract for 10h at 37 degrees C. However, in the skin homogenate and the dermis-side extract testosterone propionate rapidly degraded producing testosterone, implying that testosterone propionate rapidly degraded to testosterone during the skin permeation process. The steady-state permeation rates of testosterone in the ethanol/water systems increased exponentially as the volume fraction of ethanol increased, reaching the maximum value (2.69+/-0.69 microg cm(-2)h(-1)) at 70% (v/v) ethanol in water, and then decreasing with further increases in the ethanol volume fraction. However, in the skin permeation study with testosterone esters saturated in 70% (v/v) ethanol in water system, testosterone esters were hardly detected in the receptor solution, probably due to the rapid degradation to testosterone during the skin permeation process. Moreover, a parabolic relationship was observed between the permeation rate of testosterone and the log P values of ester derivatives. Maximum flux was achieved at a log P value of around 3 which corresponded to that of testosterone (log P = 3.4). The results showed that the skin permeation rate of testosterone and its ester derivatives was maximized when these compounds were saturated in a 70% ethanolic solution. It was also found that a log P value of around 3 is suitable for the skin permeation of testosterone related compounds.



Its possible i am misinterpreting this data, but it seems to indicate esters are degraded into their freebase during transdermal absorption.
Click to expand...
I've read this study countless times, and it doesn't hold water in real life.
A friend is using testosterone propionate cream, coupounded from the pharmacy, and his levels 24h after application are at 1400ng/dl.
I had him apply my own cream which is the same concentration and same dosage, only it's made with testosterone base, his levels at the 24h mark were only 800ng/dl.
The ester does make it past the skin layers.
 
Goingstronger said:
I've read this study countless times, and it doesn't hold water in real life.
A friend is using testosterone propionate cream, coupounded from the pharmacy, and his levels 24h after application are at 1400ng/dl.
I had him apply my own cream which is the same concentration and same dosage, only it's made with testosterone base, his levels at the 24h mark were only 800ng/dl.
The ester does make it past the skin layers.
Click to expand...
Interesting, has your friend tried other esters?
 
Goingstronger said:
Just ordered testosterone acetate thanks to you and will let you know what its solubility is in DMSO.
Imagine just having to put a few drops of DMSO every morning on your balls or shoulders to achieve 3000-5000ng/dl.

Will obviously draw bloods after 15 days of continuous use.
Click to expand...
Just checking in to see if you have started this experiment yet. I’m very much looking forward to the results. If you even have the test in that is.
 
Goingstronger said:
No that's irrelevant for DMSO, Jensen stores them in a type of plastic that doesn't leach.

The only relevant point for DMSO is to get a purity higher than 99.99% and sterile-filtered.

The only company that combines these two pre-requesites is Jensen, and stores the DMSO in a plastic that doesn't leach.
You shouldn't get DMSO from anyone else unless you plan on smelling like oyster and absorbing toxins.
Click to expand...
Jensen also sells a non sterile filtered product but still claim it is 99.99% pure. Is that good enough? It’s half the price of sterile filtered.

www.ebay.com

PHARMACEUTICAL GRADE DIMETHYL SULFOXIDE DMSO 8 OUNCE BOTTLE | eBay

DMSO is a colorless liquid solvent with a slight odor that is similar to garlic. The odor is a characteristic of DMSO and a liquid without that characteristic odor is not pure DMSO. A liquid without the odor could be anything.
www.ebay.com
 
GloryUs said:
Jensen also sells a non sterile filtered product but still claim it is 99.99% pure. Is that good enough? It’s half the price of sterile filtered.

www.ebay.com

PHARMACEUTICAL GRADE DIMETHYL SULFOXIDE DMSO 8 OUNCE BOTTLE | eBay

DMSO is a colorless liquid solvent with a slight odor that is similar to garlic. The odor is a characteristic of DMSO and a liquid without that characteristic odor is not pure DMSO. A liquid without the odor could be anything.
www.ebay.com
Click to expand...
It's fine, I buy 99.9% now, as long as it's pharm grade. Still no smell at all, just faint corn.
 
You must log in or register to reply here.

Similar threads

mikeh1998
Raw storage sanity check
Replies
6
Views
206
qadsan
qadsan
F
Toxicity of benzyl alcohol and benzyl benzoate
Replies
7
Views
211
filtros29
F
Ghoul
Skin penetration base
Replies
10
Views
371
Kermit
K
4
Making prami liquid
Replies
10
Views
173
MfgEng
M
Trenbolonetax
SLU-PP-332 Solution Discussion
3 4 5
Replies
80
Views
3K
vulpinis
V

Sponsors

Latest posts

Back
Top