I really like Modafinil - even at low doses

[mikeh1998]

Does anyone know what shelf life is like? I have some Modavigil from maybe 10-12 years back.

If it's in the blister pack it's vacuum sealed so it should last forever at room temperature away from light.

 

[Blitz Comet]

Same here. I've been on Adderall for years and have been tempted to try Modafinil just to experiment and compare, plus I've heard good things about it but I suspect the Adderall would override it's stim effect.

I've been using both and still always feel the effects of both. I don't take adderall daily though only two days a week

 

[ineffectual]

What's the best suggestion to get a legit prescription for Modafinil or armodafinil through telehealth or pcp?

 

[petit_rafalet]

My experience with modafinil is very positive. I take 100 mg every midday.
It helps me to beat the afternoon fatigue and give me an extra focus for the work out. No sides at the moment

 

[17SS]

What's the best suggestion to get a legit prescription for Modafinil or armodafinil through telehealth or pcp?

Have sleep apnea or work shift.

 

[Ghoul]

Does anyone know what shelf life is like? I have some Modavigil from maybe 10-12 years back.

Anecdotally a very long time. Seems to be a brick of a molecule, and that glorious aluminum strip India packaging to protect drugs against Monsoon season humidity is pretty much ideal. Please let us know if it works. I've heard of 8 year Moda working well, so you're is an exceptional "vintage". We know many pharmaceuticals are good for 30 years.

It doesn't degrade into anything toxic, just inert.

If you're into it, without knowing how difficult it may be to acquire in the future, 50 strips at a time, the most that PCT places will send in one pack. isn't unreasonable for building up a stash.

 

[Ghoul]

When dieting, consider using 50mg of Modafinil daily. It can significantly reduce food focus by keeping you mentally engaged and feeling productive throughout the day.

It's been clinically observed long term daily Modafinil users, over two years, have a significantly lower rates of obesity than the general population.

 

[Ghoul]

I keep forgetting to order some Armoda. At 200mg Moda does nothing for me. I need to try 300mg but that seems excessive and I’ll blow through my stock fast. And that’s if it has an effect at 300.

Often a different brand can make a difference. Which are you using?

Moda has been taken up to 5000mg without any harm besides insomnia for a couple days.

Doses over 400mg don't provided any added benefit though.

Get a different brand and some Armoda as you suggested to see what works for you,

 

[Ghoul]

I have been playing with different doses for a few weeks now. My sleep is trash really and I think I need to stop for a minute. I will wake up after only a few hours but when I wake up, I'm awake. The more I think about it my issue seems to be I'm not groggy or really tired when waking. I feel its the moda/armo. Not "feeling" taking different doses like to where I know I took it but overall not as tired during the day. Amazing stuff. Thanks @Ghoul

If sleep is an issue stick to Moda only, will wear off much earlier than Armoda.

Always take as early as possible too.

 

[BamaCrazy]

Often a different brand can make a difference. Which are you using?

Moda has been taken up to 5000mg without any harm besides insomnia for a couple days.

Doses over 400mg don't provided any added benefit though.

Get a different brand and some Armoda as you suggested to see what works for you,

I purchased Modalert 100mg.

 

[Ghoul]

I purchased Modalert 100mg.

.

Try Artvigil 150.

Also some Artvigil 50 (it's bargain priced at the right vendor), makes it easy to modulate the dose. IE, if 150 isn't enough just add a 50. The official doses for Armoda go to 250/day. I know some who find 50 strong, lol, so clearly there's a lot of individual response variation.

While you're ordering, get a few strips of Modawake 200, the different excipients and release profile may be more effective for you (a stronger initial "burst" than Modalert).

 

[NotHuman]

It's been clinically observed long term daily Modafinil users, over two years, have a significantly lower rates of obesity than the general population.

I do notice appetite suppression for the first half of the day after taking it upon rising in the morning, so I imagine that’s the mechanism.

 

[17SS]

Sunosi and Modafinil combined are good for a 1,000 mile drive or spending a few days awake. It’s just expensive if you can’t get the discount.

 

[NotHuman]

I just got some labs back and noticed my A1C went up a little and so did my LDL. I wouldn’t have considered the 200mg daily Modafinil I’ve been taking the last couple of months as a potential cause until I re-read this study showing hyperglycemia and dyslipidemia in rats.

https://www.sciencedirect.com/science/article/abs/pii/S0161813X2030036X#

There isn’t really good human evidence to back up this rat study but absence of evidence doesn’t necessarily mean evidence against.

It might be unrelated to the Modafinil but I’m wondering if anyone else who uses it daily has ever encountered anything like this.

In the meantime, I will stop taking it daily and only use sparingly.

 

[Ghoul]

I just got some labs back and noticed my A1C went up a little and so did my LDL. I wouldn’t have considered the 200mg daily Modafinil I’ve been taking the last couple of months as a potential cause until I re-read this study showing hyperglycemia and dyslipidemia in rats.

https://www.sciencedirect.com/science/article/abs/pii/S0161813X2030036X#

There isn’t really good human evidence to back up this rat study but absence of evidence doesn’t necessarily mean evidence against.

It might be unrelated to the Modafinil but I’m wondering if anyone else who uses it daily has ever encountered anything like this.

In the meantime, I will stop taking it daily and only use sparingly.

I'm pretty open minded to possibilities based on tentative evidence, but in this experiment they used other drugs to make the rats diabetic first and then gave them 50-100x the usual human dose of Modafinil.

No other evidence shows any effect of Modafinil on lipids or glucose. I don't know what they were trying to discover with this wild experiment, but it doesn't seem to have any connection to human biology.

 

[frenske]

This is where we have a conundrum similar to GLPs. "These benefits only apply to the obese, or diabetics.".

There is significant evidence suggesting benefits for "healthy" people using either Moda or GLPs, however, the ethics review for medical research required for approval of studies doesn't allow for long term experimentation in those without a "problem" that's supposed to be the target of the research. So we see a benefit, like white matter increasing after long term use "in narcolepsy" sufferers, and "stroke victims with fatigue", and the temptation is to dismiss these effects as being limited to those groups (which is always possible of course), but when you dig into the mechanism of action, it's not really anything to do with those conditions, and could very well apply to everyone, but modern research methods simply doesn't accommodate experimentation for "enhancement" purposes, only for treating illness.

There's a drug called "dalfampridine" that's showing the ability to boost "working memory", a major element of cognition closely associated with success and accomplishment, significantly, in healthy people. It's a drug for multiple sclerosis, and TLDR, improves the "electrical insulation" around nerves to prevent signals from "leaking" and therefore work more efficiently. It appears quite safe, with the major risk being making nerves too efficient, inducing tremors at too high of a dose.

It sounds like it's potentially an amazing physical and cognitive performance enhancer. Yet, studies on healthy people have been limited to 3 days. I'm eager to get my hands on some from India pharma.

@Ghoul Were you able to try out dalfampridine? Really interested in hearing your thoughts.

 

[HeatherSwanson]

It's been clinically observed long term daily Modafinil users, over two years, have a significantly lower rates of obesity than the general population.

When I take I stand all day. Makes sense.

 

[NotHuman]

I'm pretty open minded to possibilities based on tentative evidence, but in this experiment they used other drugs to make the rats diabetic first and then gave them 50-100x the usual human dose of Modafinil.

No other evidence shows any effect of Modafinil on lipids or glucose. I don't know what they were trying to discover with this wild experiment, but it doesn't seem to have any connection to human biology.

It’s not a perfect study but I don’t really know why else my A1C would jump from 5.2% to 5.6% especially on 2-3mg Retatrutide and not changing any others factors. Just an anecdote I have here that kind of blindsided me. I’ll see what coming off (which I don’t want to do) ends up doing. Still looking to see if anyone else who takes it daily noticed anything weird like that. Having glucose go up after dosing Modafinil could suggest something like this could happen.

I don’t want people to fear taking it because of this though. It could just be a “me” problem.

It could also be something unrelated I am missing.

 

[Ghoul]

It’s not a perfect study but I don’t really know why else my A1C would jump from 5.2% to 5.6% especially on 2-3mg Retatrutide and not changing any others factors. Just an anecdote I have here that kind of blindsided me. I’ll see what coming off (which I don’t want to do) ends up doing. Still looking to see if anyone else who takes it daily noticed anything weird like that. Having glucose go up after dosing Modafinil could suggest something like this could happen.

Or it could be something unrelated I am missing.

The curse of polypharmacy many of us have to deal with. 1 drug=simple. 2 drugs=check the interaction chart, 3 drugs=unlikely to find studies covering that specific combo, 5 drugs+ combinations = an unexplored frontier and on your own.

The only possible connection, if there is one, is that Moda is chewing up an enzyme necessary to metabolize something else into an active form. That's the primary way drugs interfere with each other. Enzymes, basically, either break down a drug to clear it from the body, or convert the drug into another form that has the effect we're seeking. These enzymes are limited in supply and can be exhausted, making some drugs not work, and others last longer. For instance, the elderly or those with liver dysfunction have to adjust Moda doses downwards, because it lasts much longer in those people.

If you can tell me what drugs and supplements you're using, I'll give it my best shot.

 

[keenpen]

How are you guys traveling with moda without prescription? Is it a DGAF by the TSA?