IGF-1 LR3.....WHAT WILL IT DO FOR ME ???

[BulgingKingFlair]

Hello fellow muscle enthusiasts......

Not sure if you can see my posting history, so I will brief you on my background story.

Im 40 years old, have been lifting for 25 years and cycling AAS for about 12 years. Im 5'11" and just weighed in at 244 pounds yesterday. In early May I had my right pec reattached as I blew it off the bone while warming up for the National Bench-Only record. My weight dipped to 225 by mid June, as I was just running a "light" sustanon/deca dosage to aid in a quality heal. Although im still leary to do much if any pectoral isolation exercises - I am back going very heavy on all other bodyparts and am currently running

1000mg Sustanon/wk
60 mg DBol/day
60 mg Anavar/day.

I am aware of the increased risk of liver harm from running 2 orals simultaneously - but ive run the DBol/Var combo in the past (6 weeks at a time) and it is an explosive combo for me. In 2 weeks when its time to come off the orals, I will be subbing in

Tren Enanthate 600mg/week
Equipoise 900mg/wk

in addition to the 1000mg/wk of Sustanon I am running.

Now, I was given 3x 1mg human-grade IGF-1 LR3 by a friend in the pharmaceutical business. I have no clue how to use this stuff (besides the 15-20 completely different dosing instructions ive seen on various websites).

My understanding now is that I want to inject a total of 50mcg into the muscle group I just finish training. So post shoulder workout for instance, 25mcg per delt. And that this should be run for no longer than 8 weeks.

My questions are as follows ;

1. Will this aid in the quality of heal from my pec reattachment surgery?

2. Am I correct in the dosing advice I have deciphered?

3. Since I lift 3-4 days per week - do I only inject on workout days, or also on off days? Where do I inject on off-days?

4. What kind of gains/results should I reasonably expect running this concurrently with the sustanon/tren/EQ cycle ive listed above?

I greatly appreciate any response/advice you guys can give me. As always, thanks in advance fellas.....

- KF

 

[Dr JIM]

1) if there's any evidence ANY PED promotes post-operative or post traumatic healing, I've not seen it

2) same as number ONE

3) ". ". "

4). ". ". "

 

[Dr JIM]

In fact there's more evidence that supports the notion, AAS in particular, are likely to WORSEN articular healing.

 

[Docd187123]

What will IGF1 LR3 do for you? It will leave you with a lighter wallet and possibly help with tight hips bc if that

 

[Dr JIM]

One thing AAS well do is worsen the GCM it seems your developing already!

 

[BulgingKingFlair]

One thing AAS well do is worsen the GCM it seems your developing already!

Well Jim (Dr. Numnuts), for being a "doctor" you certainly dont seem overly bright. Slight problem with literary comprehension.

You "liked" a comment about IGF-1 LR3 making my pockets lighter - when I clearly explained it was provided to me for free. Also, dont let a picture with an odd shadow and a bad "manscaping" job around my nipple cause you to rip on my physique by commenting about my supposedly developing gyno. If anything, besides what I just noted, bf% across my chest has increased slightly by not working out the muscle group for over 3 months due to my accident.

With such simple errors, I think I will just disqualify your info/advice on anything significantly more important or requiring intelligence.

 

[Juced]

I have liked the stuff personally. but there is alot of crappy quality out. it has to be properly made.
sure there is a patent on it but its still being made, just like some SARMS...
here is some info that could be of some use to some of you, I made it a while back:
Why peptides you use should be from a recombinant DNA source and not a chemically synthesized source

I want to bring something up about peptides and peptide quality. I see many people going the cheap route but there is a reason that they may be simply wasting their money. That is why I wanted to start a thread about an issue I think is going on related to efficacy of chemically synthesized IGF and most other peptides vs. recombinantly made ones.

There are many threads on here about IGF-1 and other peps giving good gains and I feel some of it may be BS or the person is having a "placebo affect", while others swear peptides are a complete scam and do nothing at all! (not true)... There might be a reason your igf1 cycle didn't give you jack shit?

Why?

I believe most are purchasing IGF-1 (for an example of a popular peptide being used) made by cheap peptide synthesis companies. However, chemical synthesis of IGF-1 lacks the correct disulfide bonds that cause the proper folding and function in the peptide chain. IGF-1 and its many analogs require 3 disulfide bonds to generate the correct folded form of the protein and this can only be accomplished in the body as naturally produced, or in E.coli bacteria as a recombinant source which is similar to how HGH is made (recombinantly).

Insulin is also very similar to the structure of IGF-1 and it also is inactive and/or unstable if synthesized chemically, it has to be made recombinantly or extracted from a biologic source (they used to extract insulin from bovine and HGH from cadavers).
Made with "recombinant DNA" means it is made in bacteria which have data input into it and "fermented" create enzymes that make these intramolecular disulfide bonds so that the protein folds into the right configuration and has the biological function it is supposed to have, having the proper amino chain is NOT enough and it is NOT that simple!

If you look into human clinical trials or current clinical treatment of patients, they now use some of these peptides as part of a therapy protocol and they use recombinant DNA made peptides, not chemically synthesized ones and for good reason.

Here is just one of many studies on how important the correct bonds are, not just the structure>
Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI > Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI


There are many cheap peptide sellers popping out like CRAZY the last couple years with ridiculously low prices that just doesn't make any sense. So I say if it seems too good to be true, then it probably is!
There is a reason some places are so cheap while others can cost more than 2X or 3X the amount of the cheaper places.

You usually get what you pay for so PLEASE do your research first!

Just because it's pricy doesn't automatically mean its top quality, you still need to research the company.
But if it is really cheap then I would just avoid it because the chances of it being properly made are minimal in this case. IMO

There is a flood of shotty quality peptides coming from china, BE SAFE AND AVOID!

What you want is the more expensive recombinant DNA made peptides! NOT the cheaply made, unstable and largely biologically inactive chemically synthesized peptides!

Many don't even have a clue about all this and that is why I am posting this thread.

Hope it helps someone!


Cheers

 

[BulgingKingFlair]

I have liked the stuff personally. but there is alot of crappy quality out. it has to be properly made.
sure there is a patent on it but its still being made, just like some SARMS...
here is some info that could be of some use to some of you, I made it a while back:
Why peptides you use should be from a recombinant DNA source and not a chemically synthesized source

I want to bring something up about peptides and peptide quality. I see many people going the cheap route but there is a reason that they may be simply wasting their money. That is why I wanted to start a thread about an issue I think is going on related to efficacy of chemically synthesized IGF and most other peptides vs. recombinantly made ones.

There are many threads on here about IGF-1 and other peps giving good gains and I feel some of it may be BS or the person is having a "placebo affect", while others swear peptides are a complete scam and do nothing at all! (not true)... There might be a reason your igf1 cycle didn't give you jack shit?

Why?

I believe most are purchasing IGF-1 (for an example of a popular peptide being used) made by cheap peptide synthesis companies. However, chemical synthesis of IGF-1 lacks the correct disulfide bonds that cause the proper folding and function in the peptide chain. IGF-1 and its many analogs require 3 disulfide bonds to generate the correct folded form of the protein and this can only be accomplished in the body as naturally produced, or in E.coli bacteria as a recombinant source which is similar to how HGH is made (recombinantly).

Insulin is also very similar to the structure of IGF-1 and it also is inactive and/or unstable if synthesized chemically, it has to be made recombinantly or extracted from a biologic source (they used to extract insulin from bovine and HGH from cadavers).
Made with "recombinant DNA" means it is made in bacteria which have data input into it and "fermented" create enzymes that make these intramolecular disulfide bonds so that the protein folds into the right configuration and has the biological function it is supposed to have, having the proper amino chain is NOT enough and it is NOT that simple!

If you look into human clinical trials or current clinical treatment of patients, they now use some of these peptides as part of a therapy protocol and they use recombinant DNA made peptides, not chemically synthesized ones and for good reason.

Here is just one of many studies on how important the correct bonds are, not just the structure>
Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI > Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI


There are many cheap peptide sellers popping out like CRAZY the last couple years with ridiculously low prices that just doesn't make any sense. So I say if it seems too good to be true, then it probably is!
There is a reason some places are so cheap while others can cost more than 2X or 3X the amount of the cheaper places.

You usually get what you pay for so PLEASE do your research first!

Just because it's pricy doesn't automatically mean its top quality, you still need to research the company.
But if it is really cheap then I would just avoid it because the chances of it being properly made are minimal in this case. IMO

There is a flood of shotty quality peptides coming from china, BE SAFE AND AVOID!

What you want is the more expensive recombinant DNA made peptides! NOT the cheaply made, unstable and largely biologically inactive chemically synthesized peptides!

Many don't even have a clue about all this and that is why I am posting this thread.

Hope it helps someone!


Cheers

Thank you so much, Juced. Now that was a quality, fact based response which I found extremely helpful.

The IGF-1 LR3 I was given is pharma-grade, given to me from a good friend who works for a Canadian Pharmaceutical company that also produces peptides, etc. for use in a laboratory/testing environment. It has been tested and is guaranteed at 98% purity.

This is why I am not at all concerned with the quality/purity of what I have received - but only whether it will benefit me in terms of continued healing of my injury as well as gaining new muscle mass - if taken "properly".

So, my answer seems to be yes - after the info provided by Juced and other research I have done today. Saw a very compelling video from an endocrinologist/North American champion bodybuilding champion who cycles IGF-1 LR3 religiously and swears by the muscle recovery/permanent new lean mass generation properties.

 

[Docd187123]

Thank you so much, Juced. Now that was a quality, fact based response which I found extremely helpful.

The IGF-1 LR3 I was given is pharma-grade, given to me from a good friend who works for a Canadian Pharmaceutical company that also produces peptides, etc. for use in a laboratory/testing environment. It has been tested and is guaranteed at 98% purity.

This is why I am not at all concerned with the quality/purity of what I have received - but only whether it will benefit me in terms of continued healing of my injury as well as gaining new muscle mass - if taken "properly".

So, my answer seems to be yes - after the info provided by Juced and other research I have done today. Saw a very compelling video from an endocrinologist/North American champion bodybuilding champion who cycles IGF-1 LR3 religiously and swears by the muscle recovery/permanent new lean mass generation properties.

Your answer is no. It will not help with healing an injury nor is it a potent mass builder.

Despite the observations of an effect of GH and IGF-I on protein synthesis, the fact remains that gains in muscle mass are not observed in healthy subjects after long-term GH administration so any benefits are unlikely to be due to muscle mass gains. In the GH plus exercise groups, circulating IGF-I levels and fat-free mass were consistently increased in comparison to placebo groups. Thus, it is possible to extrapolate that increasing circulating IGF-I would also be without consequence for muscle mass in healthy humans. Administration of IGF-I acutely activates muscle protein synthesis (Fryburg et al., 1995), but similarly to GH a 1-year administration did not result in increased lean body mass (Friedlander et al., 2001). The effects of GH on fat-free mass may be due to water retention, which is a known side effect of GH administration, or to an increase in soft tissue due to the stimulatory effects of GH on collagen synthesis.

In summary, normal GH/IGF-I function does have a role in the development and maintenance of muscle mass, as gathered from evidence in GH-deficient patients, burn patients, hypophysectomized animals, and animal models in which GH receptor and IGF-IR activity are lacking. GH or IGF-I administration have, however, no proven benefits for muscle mass in healthy subjects in whom GH function is normal (Figure 3). In most animal studies, GH is administered while the animals are still growing and this may confound the results in comparison to administration in fully grown animals. In addition, the species differences between rodents and humans in the functioning of the GH/IGF-I axis must be taken into account. Studies with transgenic and knockout animals are also complicated by the fact that the embryonic development of the tissue can be affected and this can have different consequences to altering gene expression once the animal has reached maturity.

Regulation of muscle mass by growth hormone and IGF-I

 

[BulgingKingFlair]

Well, thats spectacular. Another well-written and clearly educated response....although appreciated....has me simply more confused.

So those who swear by it.....if it DOES work to any noticeable extent for them.....must be due to an initial lack of GH or a glitch in pituitary system function which was unknowingly "corrected" by proper supplementation of IGF-1 LR3 ???

Man, in all the hours ive spent researching this - ive never come across a subject with such conflicting answers and opinions. Crazy. Its seemingly really about 50/50. Thats not good enough for me to use it, even if its free.

Anybody out there have actual experience dosing themselves and want to weigh in? It DOES seem users are the ones who swear it works - while those who have only done research swear its useless.......

 

[Docd187123]

Well, thats spectacular. Another well-written and clearly educated response....although appreciated....has me simply more confused.

So those who swear by it.....if it DOES work to any noticeable extent for them.....must be due to an initial lack of GH or a glitch in pituitary system function which was unknowingly "corrected" by proper supplementation of IGF-1 LR3 ???

Man, in all the hours ive spent researching this - ive never come across a subject with such conflicting answers and opinions. Crazy. Its seemingly really about 50/50. Thats not good enough for me to use it, even if its free.

Anybody out there have actual experience dosing themselves and want to weigh in? It DOES seem users are the ones who swear it works - while those who have only done research swear its useless.......

For those it does work on..... Placebo is a hell of a drug man.

 

[BulgingKingFlair]

For those it does work on..... Placebo is a hell of a drug man.

No doubt - lol - since im leaning massively towards this NOT working, maybe I should use it report back.....?

 

[Juced]

I would rec looking at TB500 if you are unsure. I know IGF1 helped me, but its mild and if you are looking for just mass then a simple test cycle would yield more. but i do love IGF1 and do feel it does work.
shit my deca script insert stated it wont help build muscle or enhance any physical abilities, which is clearly not true, i take studies with a grain of salt as well.. BUT i DO agree with doc on needing to take into consideration the test and conditions, specially when using mouse model, they dont always relate in the same ways specially when the mice have already been altered in some form and/or the age of the mice. I do dissagree igf1 doesnt help at all or have actions in the body to our goals here. but i do think some will find more use out of it than others depending on their genetic make up, training etc.
for ME i feel it is worth while and a decent tool.
but TB500 might be even more useful to you and i rec you look into that one.
shit OP if you got it then give it a go. just know not to expect anything too big from just one run of igf1. a few a year over a few years i feel there is an accumulation of effect ( much like HGH being used longer than 6months for most out of it) but i would not use the igf1 6mo- year straight, i would rec it cycled and re asses after about a year if its worth while to you.

 

[Juced]

Thank you so much, Juced. Now that was a quality, fact based response which I found extremely helpful.

The IGF-1 LR3 I was given is pharma-grade, given to me from a good friend who works for a Canadian Pharmaceutical company that also produces peptides, etc. for use in a laboratory/testing environment. It has been tested and is guaranteed at 98% purity.

This is why I am not at all concerned with the quality/purity of what I have received - but only whether it will benefit me in terms of continued healing of my injury as well as gaining new muscle mass - if taken "properly".

So, my answer seems to be yes - after the info provided by Juced and other research I have done today. Saw a very compelling video from an endocrinologist/North American champion bodybuilding champion who cycles IGF-1 LR3 religiously and swears by the muscle recovery/permanent new lean mass generation properties.

No prob man.
also its not just general quality, but its how its made. make sure its made like i mentioned in that post. you could ask him.

for an injury i would strongly rec trying the TB500

 

[BulgingKingFlair]

No prob man.
also its not just general quality, but its how its made. make sure its made like i mentioned in that post. you could ask him.

for an injury i would strongly rec trying the TB500

I will enquire about the processing procedure for sure. Since I already have it - and it was free, im gonna give it a shot. I dont have to worry about it being rat poison or freeze-dried spunk, so as long as I keep the dose low its very unlikely to harm me.

Im starting it October 1st, ill report back for sure. In detail.

Thanks guys for helping once again....

-BKF

 

[Ed Plucker]

Hello fellow muscle enthusiasts......

Not sure if you can see my posting history, so I will brief you on my background story.

Im 40 years old, have been lifting for 25 years and cycling AAS for about 12 years. Im 5'11" and just weighed in at 244 pounds yesterday. In early May I had my right pec reattached as I blew it off the bone while warming up for the National Bench-Only record. My weight dipped to 225 by mid June, as I was just running a "light" sustanon/deca dosage to aid in a quality heal. Although im still leary to do much if any pectoral isolation exercises - I am back going very heavy on all other bodyparts and am currently running

1000mg Sustanon/wk
60 mg DBol/day
60 mg Anavar/day.

I am aware of the increased risk of liver harm from running 2 orals simultaneously - but ive run the DBol/Var combo in the past (6 weeks at a time) and it is an explosive combo for me. In 2 weeks when its time to come off the orals, I will be subbing in

Tren Enanthate 600mg/week
Equipoise 900mg/wk

in addition to the 1000mg/wk of Sustanon I am running.

Now, I was given 3x 1mg human-grade IGF-1 LR3 by a friend in the pharmaceutical business. I have no clue how to use this stuff (besides the 15-20 completely different dosing instructions ive seen on various websites).

My understanding now is that I want to inject a total of 50mcg into the muscle group I just finish training. So post shoulder workout for instance, 25mcg per delt. And that this should be run for no longer than 8 weeks.

My questions are as follows ;

1. Will this aid in the quality of heal from my pec reattachment surgery?

2. Am I correct in the dosing advice I have deciphered?

3. Since I lift 3-4 days per week - do I only inject on workout days, or also on off days? Where do I inject on off-days?

4. What kind of gains/results should I reasonably expect running this concurrently with the sustanon/tren/EQ cycle ive listed above?

I greatly appreciate any response/advice you guys can give me. As always, thanks in advance fellas.....

- KF

I am now using IGF-1 in addition to hGH and insulin and clomid. I am currently about 6 weeks PCT and have not lost a single pound after a pretty lengthy steroid cycle. This is amazing when you think about it. IGF-1 should be use at 20mcg per day injected IM. If you're using the Long IGF-1 R3 there's no advantage to site injections. IGF-1 DES should be injected into the muscle you just worked because its half life is less than 30 minutes.
You can inject anywhere on your body. I use my delts because it easiest. I inject 20mcg post training IM. If you go much over 20mcg it won't work as well because protein hormone receptors are very sensitive and sit outside the cell, whereas androgen receptors are inside the cell. If you blast them with mega-doses the receptors will quickly down regulate and you won't gain anything. Also only use for 4 weeks then take at least 2 weeks off before restarting.

 

[BulgingKingFlair]

There we go!!! As I said, its the users who swear by it -- and non users/haters who like to shit on the whole idea.

Thanks so much for the awesome, educational, informative, and "to the point" post. Much appreciated !!!

 

[Docd187123]

There we go!!! As I said, its the users who swear by it -- and non users/haters who like to shit on the whole idea.

Thanks so much for the awesome, educational, informative, and "to the point" post. Much appreciated !!!

How do you know he even knows the IGF-1 works when he's also on clomid, HGH, and insulin????

 

[Ed Plucker]

How do you know he even knows the IGF-1 works when he's also on clomid, HGH, and insulin????

I don't this is true, but its got to be the combo of the 4 that are working and I didn't gain much if any muscle on just hGH and clomid. When I added insulin and IGF-1 I gained about 5 lbs of muscle. So I would say hGH, IGF-1, and insulin are a killer combo. Way stronger than steroids IMO.

 

[BulgingKingFlair]

How do you know he even knows the IGF-1 works when he's also on clomid, HGH, and insulin????

Have you used it?