Improvement in Endurance training with peds

[RekTest]

What about meldonium?
It hit the headlines, briefly, but it kinda disappeared

Its interesting to me no one replied to this. I did a little dive on this drug… I am so puzzled.

So it does two things for endurance,
It increases blood vessel size, thus better blood flow.
It also changes how your body uses energy, this is what puzzles me, instead of your body using fat stores it converts fully to only using carbs, glycogen stores, which is a faster process than grabbing from fat stores?

“ Meldonium is antiischemic, which means it stops things that stop blood flow, and while this may mean it improves blood flow, it's not necessarily the case. It works by blocking the use of fat for energy, which it turn prevents the production of by-products that harm the heart and arteries. Or more technically "inhibits carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process".

In effect this means it blocks carnitine from working, and thus utilization of fat for energy. The benefit of this is it drives your body to use glucose/ glycogen, which is a quicker process, and uses less oxygen. This is where it gets its performance enhancing reputation from. In theory it means more energy/endurance.”

Mildronate (Meldonium) in professional sports - monitoring doping control urine samples using hydrophilic interaction liquid chromatography - high resolution/high accuracy mass spectrometry - PubMed

To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after...

pubmed.ncbi.nlm.nih.gov

So like.. could you have “endless” energy if you just kept carbing up on this?

 

[bossetti]

In this study, the positive tests date back 21 days after the last injection. Could you send the other study pls ? Maybe this one is more recent
https://www.zora.uzh.ch/id/eprint/85281/1/Detection_of_EPO.pdf

If its like this not really good, but Better because safe than Sorry btw Data from a microdosed recombinant human erythropoietin administration study applying the new biotinylated clone AE7A5 antibody and a further optimized sarcosyl polyacrylamide gel electrophoresis protocol - PubMed

 

[bossetti]

Its interesting to me no one replied to this. I did a little dive on this drug… I am so puzzled.

So it does two things for endurance,
It increases blood vessel size, thus better blood flow.
It also changes how your body uses energy, this is what puzzles me, instead of your body using fat stores it converts fully to only using carbs, glycogen stores, which is a faster process than grabbing from fat stores?

“ Meldonium is antiischemic, which means it stops things that stop blood flow, and while this may mean it improves blood flow, it's not necessarily the case. It works by blocking the use of fat for energy, which it turn prevents the production of by-products that harm the heart and arteries. Or more technically "inhibits carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process".

In effect this means it blocks carnitine from working, and thus utilization of fat for energy. The benefit of this is it drives your body to use glucose/ glycogen, which is a quicker process, and uses less oxygen. This is where it gets its performance enhancing reputation from. In theory it means more energy/endurance.”

Mildronate (Meldonium) in professional sports - monitoring doping control urine samples using hydrophilic interaction liquid chromatography - high resolution/high accuracy mass spectrometry - PubMed

To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after...

pubmed.ncbi.nlm.nih.gov

So like.. could you have “endless” energy if you just kept carbing up on this?

Its pretty interesting, for sure the bigger vessels part, but i dont really know if you can get benefits about the carb part

 

[bossetti]

Its pretty interesting, for sure the bigger vessels part, but i dont really know if you can get benefits about the carb part

Sry i was coming back from training and was cold af so i was writing too fast, btw i think that there are compounds like cardarine and aicar (ppar delta agonists) that improve Endurance by improving fat metabolism (that Is important for aerobic things) so i have a doubt about going full carb and also you can carb max 120g for hour and its like 480 kcal in Z1 if u weight more than 30kg you probably going to burn more but i mean that i could be and i am probably wrong

 

[bossetti]

Sry i was coming back from training and was cold af so i was writing too fast, btw i think that there are compounds like cardarine and aicar (ppar delta agonists) that improve Endurance by improving fat metabolism (that Is important for aerobic things) so i have a doubt about going full carb and also you can carb max 120g for hour and its like 480 kcal in Z1 if u weight more than 30kg you probably going to burn more but i mean that i could be and i am probably wrong

I have seen that a football player and a female tennis player were probably caught using that(so It probably works lol) i dont really know why It works but tbh i dont care about how but i care about results