I stumbled on this and thought I would put it out here for thoughts. I have not dug deep into it yet and of course I will have some converse thoughts as my mind always tends to trend towards the body's natural innate ability to adjust to conditions. However, I am always open to learning to constructs that while the body is still making remarkably fast adjustments, but to consider the negatives that remain regardless, as well as whatever other conditions might occur concomitantly as an overall result. But I found this vid as an interesting lead in for though motivation..
As you may know I am a huge proponent of dispelling the myth that free-testosterone is the holy grail. When in fact the only testosterone with REAL value is that which HAS BEEN "Kidnapped" (facetious LOL) by SHBG and ALBUMIN. In fact I would tend to want to chase an investigation an more clarification as to how Albumin bound testosterone/hormones relate to the overall picture. And lets not forget that the blood proteins involve with hormones other than just testosterone. But of course I always prelude that FREE TESTOSTERONE is nothing more than proof we are making enough to be picked up to serve, and that Free-T may best POSSIBLY only offer a relative measure of hormone metabolism RATES (the real proposition which is really not measurable). I always like to also consider the constructs of metabolic structural life-cycle changes to hormones as they are employed, ELIMINATION RATES which no one seems to care to measure, and how receptor competition really behaves amongst active hormone populations and activity in the blood and receptors. I am not a medical professional but I have studied these concepts and have a few threads going over the years. I feel like this concept of blood components such as Iron, Ferritin, etc... merits its own chain of thought examination.
It should be noted that when doing blood donations (Phlebotomies)to lower blood components, there are many more factors than measuring Hemoglobin in terms of "RED BLOOD". The important thing about this is that they do not all restore at the same rate, and they may not all be available in proper proportions. E.G. When you dump blood in terms of "red cells" you are dumping the culmination of Red blood cells, the hemoglobin attached to some of them, Iron to make blood, and Ferritin (Protein) to make hemoglobin. And this is amongst the plasma which carries all blood protein as the "legitimizing enabler", whites cells, platelets, etc... So its not just about "dumping red blood cells" is all I am saying.
(Interestingly there are medically employed blood donation centers that will encourage as much as weekly blood donations as long as your hemoglobin is above 13. Consider the "Condition" of the hemoglobin in your blood is a factor as well. A guy around here once opened my eyes to some of this. But as you could imagine donating blood every week for 6 weeks straight could wind you up in a situation where the "body materials" to generate new blood may be out of whack and thus compromised for some time, and with further considerations as to what conditions the blood donor may also be experiencing as co-factors..). I found out the hard way that just because blood hemoglobin continues to appear within operational reference ranges, it may not be the best idea to just start dumping weekly. So I am just putting that out there... But here is the video that prompted this further thought. And while I think this path in interesting, it remains just another tiny piece of the puzzle.
View: https://youtu.be/qdO9btq1W3k?t=177
Moving beyond the YOU TUBE NOBLE NOVEL CAT...
This has apparently been around for some time..:
pubmed.ncbi.nlm.nih.gov
"Abstract
Aims: To assess the relation between moderate iron overload on sex hormone binding globulin (SHBG) levels and gonadotroph function in men with dysmetabolic iron overload syndrome and the effects of phlebotomy.
Methods: The relationship between magnetic resonance imaging assessed liver iron concentration (LIC) and plasma ferritin levels with total testosterone, bioavailable testosterone (BT), SHBG and LH levels, were studied in 50 men with moderate dysmetabolic iron excess, in the absence of genetic haemochromatosis, who were randomised to phlebotomy therapy or to normal care.
Results: Four patients (8%) had low total testosterone (<10.4 nmol/l) and 13 patients (26%) had low BT (<2.5 nmol/l). In the entire population, those with LIC above the median (90 μmol/l) had a higher mean SHBG (P=0.028), lower LH (P=0.039) than those with LIC below the median. In multivariable analysis (adjusted for age, and fasting insulin) LIC was significantly associated with SHBG (positively) and LH (negatively). Patients in the highest quartile of SHBG had higher LIC (P=0.010) and higher ferritinaemia (P=0.012) than those in the three other quartiles. Iron depletion by venesection did not significantly improve any hormonal levels.
Conclusions: Hypogonadism is not infrequent in men with dysmetabolic iron overload syndrome. Liver iron excess is associated with increased plasma SHBG and moderate hypogonadotrophic hypogonadism. Phlebotomy therapy needs further investigation in symptomatic hypogonadal men with dysmetabolic iron excess."
That article basically says nahh we didn't find a whole lot of hormone help here with blood letting but we def want to study more. This was 2011 of course. But if a brief test in blood letting to improve hormone levels (NOTE THIS DOES NOT MEAN FUNCTION), then what is the point of this line of study.?
Assuming SHBG blood measure as "Free" and not already involved with a hormone or who knows what else and factors. BUT, it's obviously always been my supposition that if you have High SHBG then there is a preclusion blocking the necessitation of said employment. But then WHY the high levels if the body adjust on a dime.? Keep in mind SHBG is produced in the LIVER, and we must consider IRON'S relation to liver function, and if we get outside the box then what other factors could be involved preventing a clear picture. The body is a "SYSTEM" after all... Its also been generally correlated over the years that otherwise healthy males on TRT have low SHBG levels around 12. I would assume this is because the excess exogenous testosterone supply is utilizing the SHBG. But IS IT? Or has the body just decreased SHBG production to prevent the already intentionally downward natural T production from being circumvented. So what conditions are applying to this correlation of Excess Iron and High SHBG, as I do not believe the minds behind these minds behind this line of questioning as considering how exogenous T application applies to their initial observations. I believe we are just talking about folks with high SHBG and high IRON and how that relates to blood lettings from a hormonal perspective so far...
*** Can you ever really truly "remove iron" from the human system?? really. I am here to testify the mass of my skeletal system would indication it would take a lifetime to spend it all and I have one of the heaviest set of bones on the planet. Further again we just scientifically have very difficult times discerning the difference between "Excess" and "True active metabolism rates", and how these factors act in REAL TIME.. It does kinda look like these guys started smothering up advancing the subject of iron in the body back around 2010 and beginning the quest to see how it involves with hormones and general metabolic dysfunction. But not yet so hormone oriented as a primary.
pubmed.ncbi.nlm.nih.gov
This one is just general sci-fi tally-in-time way above my pay grade, but I find it interesting that while they discuss "Iron regulating proteins", they fail to discern "Protein regulating iron".... So read that sentence again and if you already know me you knew I was going to blow that wall right off the box out of the gate. This reverse take on this may be what these guys are currently onto at last.
NOW... Is interesting and I will offer some improv...
pubmed.ncbi.nlm.nih.gov
_____________________________________________
NOTE This article actually dates to 1992 as doc'd on PudMed opening language format. But what does that mean in the forum of PUBMED.?? I wonder how long it took to publish this article from the date of the study conclusion? I wonder how you tell the actual RESEARCH DATE vs. The DATE OF PUBMED PUBLICATION? Am i missing something? Never thought to ask before. But do ya think they can just "Manually Mandela Effect" past studies into the flow quietly as subjects become more politically feasible over time??
_______________________________
Thats it for now on this one and I'll be back. But I just think its interesting the possible link with body iron supersaturation as "Overload" as it related to SHBG and hormones, if this really exist, and how relating to co-factors unclear and many for sure. One thing that always catches my attention in medicine is when we start discussing body minerals and METALS as they relate as I believe there has been a total failure in medical science to determine the relation of ELECTRICAL CHARGES pertaining the animal life, health, and modulation thereof. I'm saying we tend to want to modulate the body the Chemicals and Organic substrates, as opposted to even making the attempt to just see what is going on electrically throughout the body in various conditions. So when I see worlds like IRON, ZINC, POTASSIUM, and especially the miniscule metals like Copper and chromium, I get excitable as we are essentially a "Walking SOLS, Stars, or even BIOLOGICAL ROBOTS operating on complex code which is modfiable from a full range of things varying from "Food" to chems to VIRAL CODE APPLICATION(RNA). If you consider with both D/C (BATTTERY STORES) and A/C like (ACTIVE CURRENT) activity involved in life processes, I just don't see how these constructs can be omitted my current science any longer).
More interestingly is how does electrical modulation of animal biological systems relate to spirituality, as technically we are eternal electrical signals and waveforms in TIME which capture, involve with, and modulate the activity of various matter (Earthborn matter for our purpose in this dimension). So you have ENERGY, MATTER, and VIBRATION (RESONANCE). TIME being the yardstick that the vibration of matter is measured by. The frequency/resonance of said matter pertaining directly to our defined FUNCTIONAL DIMENSION.. One would think that to measure body electrics might even offer a possible glace in the never ending organic hunt for the soul. One would wonder would tinkering with such even tend to possibly change the intended eternal waveform and physical manifestation of a person, and alter their spirit as the connection to the soul? And once you consider this construct to this extreme degree, if you just take two steps back doesn't it start to look like there is a relation in biological science. NOTE the INATE CONTRADICTION in the prase "Biological Science". While it does not, it somehow accidentally imparts for get that 220 over on the wall it'l kill ya...
Trip over for now. But we are going to focus on how IRON relates to HORMONE ACTIVITY in the body, and what goes from that
.
And if anyone reads this and sees typos or obvious errors or misconceptions please point them out as i always fire from hip with little edit and leaves much room for error and well as personal growth and learning. Thanks in advance.
-note to self next time review and open study into IRON, PANCREAS, and INSULIN SENSITIVITY are involved and potentially related to SHBG,,
As you may know I am a huge proponent of dispelling the myth that free-testosterone is the holy grail. When in fact the only testosterone with REAL value is that which HAS BEEN "Kidnapped" (facetious LOL) by SHBG and ALBUMIN. In fact I would tend to want to chase an investigation an more clarification as to how Albumin bound testosterone/hormones relate to the overall picture. And lets not forget that the blood proteins involve with hormones other than just testosterone. But of course I always prelude that FREE TESTOSTERONE is nothing more than proof we are making enough to be picked up to serve, and that Free-T may best POSSIBLY only offer a relative measure of hormone metabolism RATES (the real proposition which is really not measurable). I always like to also consider the constructs of metabolic structural life-cycle changes to hormones as they are employed, ELIMINATION RATES which no one seems to care to measure, and how receptor competition really behaves amongst active hormone populations and activity in the blood and receptors. I am not a medical professional but I have studied these concepts and have a few threads going over the years. I feel like this concept of blood components such as Iron, Ferritin, etc... merits its own chain of thought examination.
It should be noted that when doing blood donations (Phlebotomies)to lower blood components, there are many more factors than measuring Hemoglobin in terms of "RED BLOOD". The important thing about this is that they do not all restore at the same rate, and they may not all be available in proper proportions. E.G. When you dump blood in terms of "red cells" you are dumping the culmination of Red blood cells, the hemoglobin attached to some of them, Iron to make blood, and Ferritin (Protein) to make hemoglobin. And this is amongst the plasma which carries all blood protein as the "legitimizing enabler", whites cells, platelets, etc... So its not just about "dumping red blood cells" is all I am saying.
(Interestingly there are medically employed blood donation centers that will encourage as much as weekly blood donations as long as your hemoglobin is above 13. Consider the "Condition" of the hemoglobin in your blood is a factor as well. A guy around here once opened my eyes to some of this. But as you could imagine donating blood every week for 6 weeks straight could wind you up in a situation where the "body materials" to generate new blood may be out of whack and thus compromised for some time, and with further considerations as to what conditions the blood donor may also be experiencing as co-factors..). I found out the hard way that just because blood hemoglobin continues to appear within operational reference ranges, it may not be the best idea to just start dumping weekly. So I am just putting that out there... But here is the video that prompted this further thought. And while I think this path in interesting, it remains just another tiny piece of the puzzle.
View: https://youtu.be/qdO9btq1W3k?t=177
Moving beyond the YOU TUBE NOBLE NOVEL CAT...
This has apparently been around for some time..:
Liver iron overload is associated with elevated SHBG concentration and moderate hypogonadotrophic hypogonadism in dysmetabolic men without genetic haemochromatosis - PubMed
Hypogonadism is not infrequent in men with dysmetabolic iron overload syndrome. Liver iron excess is associated with increased plasma SHBG and moderate hypogonadotrophic hypogonadism. Phlebotomy therapy needs further investigation in symptomatic hypogonadal men with dysmetabolic iron excess.
pubmed.ncbi.nlm.nih.gov
"Abstract
Aims: To assess the relation between moderate iron overload on sex hormone binding globulin (SHBG) levels and gonadotroph function in men with dysmetabolic iron overload syndrome and the effects of phlebotomy.
Methods: The relationship between magnetic resonance imaging assessed liver iron concentration (LIC) and plasma ferritin levels with total testosterone, bioavailable testosterone (BT), SHBG and LH levels, were studied in 50 men with moderate dysmetabolic iron excess, in the absence of genetic haemochromatosis, who were randomised to phlebotomy therapy or to normal care.
Results: Four patients (8%) had low total testosterone (<10.4 nmol/l) and 13 patients (26%) had low BT (<2.5 nmol/l). In the entire population, those with LIC above the median (90 μmol/l) had a higher mean SHBG (P=0.028), lower LH (P=0.039) than those with LIC below the median. In multivariable analysis (adjusted for age, and fasting insulin) LIC was significantly associated with SHBG (positively) and LH (negatively). Patients in the highest quartile of SHBG had higher LIC (P=0.010) and higher ferritinaemia (P=0.012) than those in the three other quartiles. Iron depletion by venesection did not significantly improve any hormonal levels.
Conclusions: Hypogonadism is not infrequent in men with dysmetabolic iron overload syndrome. Liver iron excess is associated with increased plasma SHBG and moderate hypogonadotrophic hypogonadism. Phlebotomy therapy needs further investigation in symptomatic hypogonadal men with dysmetabolic iron excess."
That article basically says nahh we didn't find a whole lot of hormone help here with blood letting but we def want to study more. This was 2011 of course. But if a brief test in blood letting to improve hormone levels (NOTE THIS DOES NOT MEAN FUNCTION), then what is the point of this line of study.?
Assuming SHBG blood measure as "Free" and not already involved with a hormone or who knows what else and factors. BUT, it's obviously always been my supposition that if you have High SHBG then there is a preclusion blocking the necessitation of said employment. But then WHY the high levels if the body adjust on a dime.? Keep in mind SHBG is produced in the LIVER, and we must consider IRON'S relation to liver function, and if we get outside the box then what other factors could be involved preventing a clear picture. The body is a "SYSTEM" after all... Its also been generally correlated over the years that otherwise healthy males on TRT have low SHBG levels around 12. I would assume this is because the excess exogenous testosterone supply is utilizing the SHBG. But IS IT? Or has the body just decreased SHBG production to prevent the already intentionally downward natural T production from being circumvented. So what conditions are applying to this correlation of Excess Iron and High SHBG, as I do not believe the minds behind these minds behind this line of questioning as considering how exogenous T application applies to their initial observations. I believe we are just talking about folks with high SHBG and high IRON and how that relates to blood lettings from a hormonal perspective so far...
*** Can you ever really truly "remove iron" from the human system?? really. I am here to testify the mass of my skeletal system would indication it would take a lifetime to spend it all and I have one of the heaviest set of bones on the planet. Further again we just scientifically have very difficult times discerning the difference between "Excess" and "True active metabolism rates", and how these factors act in REAL TIME.. It does kinda look like these guys started smothering up advancing the subject of iron in the body back around 2010 and beginning the quest to see how it involves with hormones and general metabolic dysfunction. But not yet so hormone oriented as a primary.
[Regulation of the iron metabolism] - PubMed
Regulation of uptake, utilization, release and storage of iron occurs at the gene level. Hepcidin is currently considered to be the <<key regulator>> of the iron balance. Intracellular iron balance is maintained by iron regulating proteins. Synthesis of ferritin increases with high iron …
pubmed.ncbi.nlm.nih.gov
NOW... Is interesting and I will offer some improv...
Testosterone treatment of men with idiopathic hemochromatosis - PubMed
Patients with chronic liver disease usually exhibit low plasma levels of testosterone with loss of libido and potency; this is also valid in male patients suffering from idiopathic hemochromatosis (IHC), in whom nowadays the diagnosis is made at an earlier age. Therefore, the effect of...
pubmed.ncbi.nlm.nih.gov
_____________________________________________
NOTE This article actually dates to 1992 as doc'd on PudMed opening language format. But what does that mean in the forum of PUBMED.?? I wonder how long it took to publish this article from the date of the study conclusion? I wonder how you tell the actual RESEARCH DATE vs. The DATE OF PUBMED PUBLICATION? Am i missing something? Never thought to ask before. But do ya think they can just "Manually Mandela Effect" past studies into the flow quietly as subjects become more politically feasible over time??
_______________________________
"Abstract
Patients with chronic liver disease usually exhibit low plasma levels of testosterone with loss of libido and potency; this is also valid in male patients suffering from idiopathic hemochromatosis (IHC), [HALT - Idiopathic Hemochromatosis meaning SPONTANEOUS CAUSED BY UNKNOWN FACTORs BODY TISSUE AND ORGAN BUILD UP AND OVERLOAD OF IRON..], in whom nowadays the diagnosis is made at an earlier age. Therefore, the effect of testosterone treatment was studied in 10 patients with IHC. After the application of 250 mg testosterone enanthate i.m., the plasma testosterone (from 2.4 +/- 1.9 to 20.1 +/- 7.4 ng/ml) and estradiol (from 17.4 +/- 6.3 to 38.5 +/- 14.2 pg/ml) levels increased significantly. The rise of estradiol was in the range of controls and smaller than reported in other chronic liver diseases. In a long-term study, 250 mg testosterone enanthate was given 4-weekly for 33-96 months to 5 patients with IHC. General well-being, libido, and potency recovered almost immediately. [HALT - We can assume that there was ample SHBG is they were measuring hormones recovered. This acticle is not really describing irons relation to SHBG, but moreso possibly sex hormones].Over a treatment period of 27.3 patient years, symptoms of hyperestrogenism (gynecomastia) or (portal vein) thrombosis were not seen, both of which had been described in patients with alcoholic liver cirrhosis. There was no deterioration of liver function. The effect of testosterone treatment on the patients' well-being and plasma hormone concentrations remained unchanged over the whole period of testosterone treatment. [HALT - This is a shitty vague statement about patients with alcohol related cirrhosis UNCLEAR. Are they saying these patients had his issue prior to study or it happened to alcholics in the study?].Thus, in male patients with IHC and lowered plasma testosterone, treatment with testosterone enanthate may be instituted. Because of the positive effects on general well-being, liver regeneration capacity, and potency, testosterone should especially be administered to younger subjects suffering from IHC." [HALT - They are basically saying here that in average 3-8years of patient treatment it was real safe and effective and especially recommending in young people with low hormones correlating with iron overload because they had otherwise healthy bodies and livers - NONE OF THIS ACTUALLY QUALIFIES THAT THEY JUST DID NOT ENJOY A HORMONE JACK UP, WHAT HAPPENED TO THEIR IRON LEVELS, DID THEY BLOOD DUMP, all that jazz. Maybe there is more in the complete article and this is just a very limited summary].Thats it for now on this one and I'll be back. But I just think its interesting the possible link with body iron supersaturation as "Overload" as it related to SHBG and hormones, if this really exist, and how relating to co-factors unclear and many for sure. One thing that always catches my attention in medicine is when we start discussing body minerals and METALS as they relate as I believe there has been a total failure in medical science to determine the relation of ELECTRICAL CHARGES pertaining the animal life, health, and modulation thereof. I'm saying we tend to want to modulate the body the Chemicals and Organic substrates, as opposted to even making the attempt to just see what is going on electrically throughout the body in various conditions. So when I see worlds like IRON, ZINC, POTASSIUM, and especially the miniscule metals like Copper and chromium, I get excitable as we are essentially a "Walking SOLS, Stars, or even BIOLOGICAL ROBOTS operating on complex code which is modfiable from a full range of things varying from "Food" to chems to VIRAL CODE APPLICATION(RNA). If you consider with both D/C (BATTTERY STORES) and A/C like (ACTIVE CURRENT) activity involved in life processes, I just don't see how these constructs can be omitted my current science any longer).
More interestingly is how does electrical modulation of animal biological systems relate to spirituality, as technically we are eternal electrical signals and waveforms in TIME which capture, involve with, and modulate the activity of various matter (Earthborn matter for our purpose in this dimension). So you have ENERGY, MATTER, and VIBRATION (RESONANCE). TIME being the yardstick that the vibration of matter is measured by. The frequency/resonance of said matter pertaining directly to our defined FUNCTIONAL DIMENSION.. One would think that to measure body electrics might even offer a possible glace in the never ending organic hunt for the soul. One would wonder would tinkering with such even tend to possibly change the intended eternal waveform and physical manifestation of a person, and alter their spirit as the connection to the soul? And once you consider this construct to this extreme degree, if you just take two steps back doesn't it start to look like there is a relation in biological science. NOTE the INATE CONTRADICTION in the prase "Biological Science". While it does not, it somehow accidentally imparts for get that 220 over on the wall it'l kill ya...
Trip over for now. But we are going to focus on how IRON relates to HORMONE ACTIVITY in the body, and what goes from that
.And if anyone reads this and sees typos or obvious errors or misconceptions please point them out as i always fire from hip with little edit and leaves much room for error and well as personal growth and learning. Thanks in advance.
-note to self next time review and open study into IRON, PANCREAS, and INSULIN SENSITIVITY are involved and potentially related to SHBG,,
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strange, yet true... think the expirement is putting magnet to steel wool and rusting the steel wool and trying again... something like that
