birthdefectAU
New Member
Hi Meso, this is my first post here. I originally made an account just so it would be easier to lurk on the site and view images, but I realised I couldn't comment on the Steroid Underground until I earn privileges to do so. This poll is something I've thought about for a while, I imagine its bound to happen eventually.
What I mean by the ideal SARM + SERM, is something that acts as both an estrogen and androgen antagonist within the pituitary and hypothalamus glands, and acts as an androgen agonist in muscle tissue. I'm sure readers here would know, maintaining separation between different androgen receptors can be a bit of a pain in the ass, which is why fully non suppressive SARMs don't seem to exist yet.
Out of the current SERMs that are available, I, and I'm sure many others, agree that enclomiphene is the best acting SERM for PCT. But there is one thing that, mechanistically, which I'm not the biggest fan of, it's effect on IGF-1. I'm sorry if this is a misinformed post and that its negative effect isn't that noticeable. I would imagine that the theoretical SARM+SERM would either not act on the liver at all or potentially act as a mild androgen receptor agonist.
What do you think?
What I mean by the ideal SARM + SERM, is something that acts as both an estrogen and androgen antagonist within the pituitary and hypothalamus glands, and acts as an androgen agonist in muscle tissue. I'm sure readers here would know, maintaining separation between different androgen receptors can be a bit of a pain in the ass, which is why fully non suppressive SARMs don't seem to exist yet.
Out of the current SERMs that are available, I, and I'm sure many others, agree that enclomiphene is the best acting SERM for PCT. But there is one thing that, mechanistically, which I'm not the biggest fan of, it's effect on IGF-1. I'm sorry if this is a misinformed post and that its negative effect isn't that noticeable. I would imagine that the theoretical SARM+SERM would either not act on the liver at all or potentially act as a mild androgen receptor agonist.
What do you think?
