Lab work should I be concerned?

[accidentaljedi173]

Can finasteride produce these results for ast/alt. Also how can I reduce my rbc, hemoglobin and hematocrit. The ldl is for sure from masteron. Are any of these elevated results worrying?

 

[readalot]

Also how can I reduce my rbc, hemoglobin and hematocrit.

What are you running? Your Hgb, Hct is very high. Reduce your dosages and consider cRP/ESR testing. Past my comfort zone.


More info here if interested.

Grapefruit vs. Hematocrit

In your research, have you come across any promising ways to lower H/H in steroid users? @readalot any data on enarapril’s effects on lowering H and H?

thinksteroids.com

Your LFTs slightly elevated. Not too bad.

 

[accidentaljedi173]

What are you running? Your Hgb, Hct is very high. Reduce your dosages and consider cRP/ESR testing. Past my comfort zone.


More info here if interested.

Grapefruit vs. Hematocrit

In your research, have you come across any promising ways to lower H/H in steroid users? @readalot any data on enarapril’s effects on lowering H and H?

thinksteroids.com

Your LFTs slightly elevated. Not too bad.

Currently running 250test c and 250 mast e. Unfortunately I cannot have grapefruit as my medication states it's to be avoided. I've now doubled up on fish oil, increase fiber, added citrus bergamot, and will look into donating blood. Hopefully this will be enough

 

[readalot]

Currently running 250test c and 250 mast e. Unfortunately I cannot have grapefruit as my medication states it's to be avoided. I've now doubled up on fish oil, increase fiber, added citrus bergamot, and will look into donating blood. Hopefully this will be enough

I didn't recommend grapefruit. Take a look at the link when you have time.

 

[accidentaljedi173]

I didn't recommend grapefruit. Take a look at the link when you have time.

My apologies the title mislead me a bit. I should start baby aspirin. I have no experience in natokinase research. I am currently on Lisinopril already also on atorvistatin.

 

[Middus]

Did you exercise the day before or same day as the bloodwork? That can account for the elevated AST/ALT.
Might need to watch the red blood cell values. Some of your test is being converted to estrogen

 

[accidentaljedi173]

Did you exercise the day before or same day as the bloodwork? That can account for the elevated AST/ALT.
Might need to watch the red blood cell values. Some of your test is being converted to estrogen

I did work out quite extensively. My e2 has usually remained in the 50's when on 250mg test so I didn't put it on the panel.

 

[Middus]

I did work out quite extensively. My e2 has usually remained in the 50's when on 250mg test so I didn't put it on the panel.

I only mentioned the e2 cos that is what is believed to stimulate the increased red-blood production in stem cells. However this rbc count isn't worrisome. Just something to keep an eye on in case it gets worse.

 

[accidentaljedi173]

I only mentioned the e2 cos that is what is believed to stimulate the increased red-blood production in stem cells. However this rbc count isn't worrisome. Just something to keep an eye on in case it gets worse.

I'm taking action to reduce it so hopefully everything helps

 

[readalot]

e2 cos that is what is believed to stimulate the increased red-blood production in stem cells

Really? Tell me more. So OP just needs to drop his E2 and he should be g2g?

Please provide evidence for your claim.

Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis - PMC

Context: The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown. Objective: The aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory ...

www.ncbi.nlm.nih.gov

Protective role of estrogen against excessive erythrocytosis in Monge's disease - PubMed

Monge's disease (chronic mountain sickness (CMS)) is a maladaptive condition caused by chronic (years) exposure to high-altitude hypoxia. One of the defining features of CMS is excessive erythrocytosis with extremely high hematocrit levels. In the Andean population, CMS prevalence is vastly...

pubmed.ncbi.nlm.nih.gov

Longitudinal Changes in Hematologic Parameters Among Transgender People Receiving Hormone Therapy - PubMed

Our results support previous recommendations that hematological parameters of transgender people receiving HT should be interpreted based on their affirmed gender, rather than their sex documented at birth. The clinical significance of erythrocytosis following testosterone therapy, as well as...

pubmed.ncbi.nlm.nih.gov

 

[readalot]

I'm taking action to reduce it so hopefully everything helps

Why?

 

[accidentaljedi173]

Why?

Not my e2, but my hematocrit, rbc, hemoglobin. I will put e2 on my next blood test but this is never a problem when I'm on just testosterone. My assumption is it's because I'm on 500mg total of gear between test and mast.

 

[Jin23]

Can finasteride produce these results for ast/alt. Also how can I reduce my rbc, hemoglobin and hematocrit. The ldl is for sure from masteron. Are any of these elevated results worrying?
View attachment 277792View attachment 277793

I will echo @readalot 's opinion. Hematocrit is venturing out of my comfort zone too. With 500mg's of total gear you consider to be on cycle, correct?

You need an iron panel. Always do an iron panel (TSAT, serum iron, ferritin). And do check hsCRP.

Depending on your iron panel, you should consider doing a blood donation and/or dropping your androgen load down to a normal physiological range, ie. app. 750 ngdl at Tmax.

 

[readalot]

Not my e2, but my hematocrit, rbc, hemoglobin. I will put e2 on my next blood test but this is never a problem when I'm on just testosterone. My assumption is it's because I'm on 500mg total of gear between test and mast.

Gotcha. Thanks for clarifying.

 

[accidentaljedi173]

I will echo @readalot 's opinion. Hematocrit is venturing out of my comfort zone too. With 500mg's of total gear you consider to be on cycle, correct?

You need an iron panel. Always do an iron panel (TSAT, serum iron, ferritin). And do check hsCRP.

Depending on your iron panel, you should consider doing a blood donation and/or dropping your androgen load down to a normal physiological range, ie. app. 750 ngdl at Tmax.

I do absolutely consider even 250mg a cycle for myself. 500 total mg is definitely a cycle. I will look into an iron panel ASAP for my next blood test. Also have been looking into donating blood already as an option to lower my hct. I will be dropping my dose soon as well.

 

[Middus]

Really? Tell me more. So OP just needs to drop his E2 and he should be g2g?

Please provide evidence for your claim.

Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis - PMC

Context: The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown. Objective: The aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory ...

www.ncbi.nlm.nih.gov

Protective role of estrogen against excessive erythrocytosis in Monge's disease - PubMed

Monge's disease (chronic mountain sickness (CMS)) is a maladaptive condition caused by chronic (years) exposure to high-altitude hypoxia. One of the defining features of CMS is excessive erythrocytosis with extremely high hematocrit levels. In the Andean population, CMS prevalence is vastly...

pubmed.ncbi.nlm.nih.gov

Longitudinal Changes in Hematologic Parameters Among Transgender People Receiving Hormone Therapy - PubMed

Our results support previous recommendations that hematological parameters of transgender people receiving HT should be interpreted based on their affirmed gender, rather than their sex documented at birth. The clinical significance of erythrocytosis following testosterone therapy, as well as...

pubmed.ncbi.nlm.nih.gov

I don't know what you are trying to get at. E2 is one of the theories behind why haematocrit rises when you use exogenous androgen. The lowering MCH and MCV and increasing RDW tells me some erythropoiesis is happening. Testosterone has a few more theories, one of which you posted. There are studies that show E2 promoting haematopoietic stem cell proliferation. you can google them. He asked What he should be concerned about and has been told.

 

[Jin23]

I only mentioned the e2 cos that is what is believed to stimulate the increased red-blood production in stem cells.

You aren't a native english speaker right? The way in which this sentence is worded it sounds like "estradiol is What stimulates rbc's" as in, estradiol is The primary reason why rbc's and htc elevate on cycle. Do you understand now why @readalot was concerned?

 

[accidentaljedi173]

How much of a role will dehydration play to these results? I did do this test fasted and with no water for 12+ hours. Normally I have around 1.5-2 gallons a day with 1 gallon being with electrolytes. My question being is if I did this test hydrated would the results be better? Or would these "hydrated results" be false compared to "dehydrated results?"

 

[Middus]

How much of a role will dehydration play to these results? I did do this test fasted and with no water for 12+ hours. Normally I have around 1.5-2 gallons a day with 1 gallon being with electrolytes. My question being is if I did this test hydrated would the results be better? Or would these "hydrated results" be false compared to "dehydrated results?"

Dehydration will affect HCT and HB if severe enough, but looking at your metabolic panel, if you were 'badly' dehydrated, your BUN, Creatinine should also track higher and EGFR should drop

 

[Jin23]

One doesn't need to be severely dehydrated for their bloods to be affected. Granted, the more dehydrated the more bloods will be affected. His hct, however, certainly isn't that high because of dehydration. Might be 0.5% or something in that ballpark.