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Thanks for the link. Do you realize, probably NOT, that the study supports ALL that I have posted and NONE of what you posted!!!
We will ignore your already backtracking from "At some point, large increases in dose produce negligible increases in serum concentrations" to "I may have mispoken earlier. Maybe I can clarify. The effect of doubling the dose does not seem to double the serum concentration. Mathematically,"
You went from "negligible" increases to have "mispoken" [sic].
But, still WRONG. There is a linear relationship between the dose administered and the serum level. You even demonstrate this fact by the values posted taken directly from the study.
weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk ... graded doses of testosterone resulted in mean nadir testosterone concentrations of 253, 306, 542, 1,345, and 2,370 ng/dl at the 25-, 50-, 125-, 300-, and 600-mg doses, respectively.
Hint: 2,370/1,345 = 1.76; 1,345/542 = 2.48; 542/306 = 1.77; 306/253 = 1.21
Do you know why one would not expect a linear relationship at the lower end?
And, at the upper end with even greater doses, the linear relationship might prove even greater?
Regardless, if you plot this, one obtains a linear relationship. [And, this even comes with a surprise (later).]
Further, the study supports the 10X rough estimate.
Hint: "nadir"
Now, if one was to check for PCT or UG would it be of import to know the timing of the test to the drug administration?
Another point, what do you have to offer or propose as a method? I did not read anything except the obvious costly analysis, which is beyond almost all and as I will show later not necessary.
There is another point I will address later.
Hormone levels.
Serum total and free testosterone levels (Table
2), measured during
week 16, 1 wk after the previous injection, were linearly dependent on the testosterone dose (
P = 0.0001). Serum total and free testosterone concentrations decreased from baseline in men receiving the 25- and 50-mg doses and increased at 300- and 600-mg doses. Serum LH levels were suppressed in all groups. Serum SHBG levels decreased dose dependently at the 300- and 600-mg doses but did not change in other groups. Serum IGF-I concentrations increased dose dependently at the 300- and 600-mg doses (correlation between log testosterone level and change in IGF-I = 0.55,
P = 0.0001). IGFBP-3 levels did not change significantly in any group.
- http://ajpendo.physiology.org/highwire/markup/118276/expansion?width=1000&height=500&iframe=true&postprocessors=highwire_figures%2Chighwire_math (View popup)
- Collapse inline
Table 2.
Serum total and free testosterone, LH, FSH, SHBG, and IGF-I levels
Testosterone
DoseBaseline
Week 16Change from BaselineP vs. Zero Change
Testosterone (ng/dl) (overall ANOVA P = 0.0001)
25 mg593 ± 48253 ± 66−340 ± 850.0029
50 mg566 ± 78306 ± 58−260 ± 640.0037
125 mg553 ± 53570 ± 7557 ± 750.7425
300 mg653 ± 501,345 ± 139691 ± 1430.0005
600 mg632 ± 632,370 ± 1501,737 ± 1560.0001
Free testosterone (pg/ml) (overall ANOVA P = 0.0001)
25 mg62 ± 629 ± 5−33 ± 80.0014
50 mg57 ± 632 ± 3−25 ± 50.0009
125 mg49 ± 552 ± 83 ± 70.8601
300 mg71 ± 7138 ± 2167 ± 180.0012
600 mg64 ± 5275 ± 30211 ± 310.0001
LH (U/l) (overall ANOVA P = 0.8054)
25 mg3.5 ± 0.40.3 ± 0.1−3.2 ± 0.40.0001
50 mg3.8 ± 0.30.6 ± 0.3−3.0 ± 0.40.0008
125 mg3.4 ± 0.30.5 ± 0.1−2.8 ± 0.40.0001
300 mg3.7 ± 0.50.6 ± 0.1−3.5 ± 0.50.0002
600 mg3.3 ± 0.30.6 ± 0.4−2.9 ± 0.40.0001
SHBG (nmol/l) (overall ANOVA P = 0.0001)
25 mg29.1 ± 2.928.5 ± 3.6−0.6 ± 2.90.8497
50 mg24.4 ± 3.421.1 ± 3.2−3.3 ± 1.10.0202
125 mg33.1 ± 4.228.9 ± 3.8−4.2 ± 2.60.1410
300 mg31.4 ± 3.822.4 ± 3.9−9.1 ± 3.70.0348
600 mg40.1 ± 4.920.6 ± 3.2−19.5 ± 2.80.0001
IGF-I (ng/ml) (overall ANOVA P = 0.0001)
25 mg268 ± 26261 ± 35−7 ± 190.7462
50 mg246 ± 14225 ± 12−20 ± 100.0797
125 mg299 ± 24282 ± 31−18 ± 170.3284
300 mg314 ± 24388 ± 3074 ± 280.0272
600 mg227 ± 20304 ± 2177 ± 130.0001
- Values on each day represent the mean (±SE) of all available values on that day. However, the change represents the difference between paired values only. Treatment values represent the day 113 (week 16) values, obtained 1 wk after the previous testosterone injection. We used week 16 rather thanweek 20 values because week 20 values were not always drawn exactly 1 wk after the previous injection. LH and FSH, luteinizing and follicle-stimulating hormones, respectively; SHBG, sex hormone-binding globulin; IGF-I, insulin-like growth factor I. To convert total testosterone levels to nmol/l, multiply by 0.03467. To convert free testosterone levels to pg/ml, multiply by 3.467.
