mikestrong - BACK AGAIN! INTL & USD Source (For VIPs)!

[johnnyBALLZ]

Eminem I stand by my gear being dosed correctly. I think we have something pending, I will cancel it if it is not to late & then refund you. I don't want unhappy VIP
For anyone to claim my product is underdosed due to blood work is ignorant. Test my product instead, to see it is the real deal. I remember reading about Androgen Receptors being non receptive, saturated & also blocked.
Tileguy had high Estadiol:
Here is an article:
efer people to this information.

From the beginning...

Estradiol is an estrogen. It is known on blood tests as E2. Many people (even doctors) simply call it estrogen.

Why it Matters

There are basically two reasons we care about estradiol.

The first is that E2 is a powerful testosterone receptor antagonist. What this means is that estradiol binds to androgen receptors and renders them useless. When testosterone binds to an androgen receptor, it activates the receptor and you get the effect you're looking for. When estradiol binds to that receptor, it blocks testosterone from binding, yet it does not active the receptor, so nothing happens.

This means that if your estradiol is high, no matter how much testosterone you have, it isn't helping you as it should because too many of your androgen receptors are blocked by estradiol and your free testosterone has no where to go. Testosterone can't do you any good if it doesn't have receptors available to activate.

It can even get worse... because high levels of estradiol can cause the downregulation of androgen receptors. This means that your body may respond to higher levels of estradiol by creating fewer androgen receptors as cells are replaced in normal regeneration. In other words, not only does estradiol block the available androgen receptors, it causes your body to produce fewer of them in the future! This is one reason why raising testosterone levels may not have any immediate effect. It may be that your receptors have downregulated and so you'll need to lower estradiol and increase testosterone in order to get your body to upregulate again and this takes time.

The second reason we care about estradiol is that you also have estrogen receptors and estradiol binds to them and causes them to activate. This is fine if you want to grow man boobs, store fat on your belly, and have an enlarged prostate, but not so good if you want to look and feel like a man.

Where It Comes From

Brushing aside the highly controversial subject of environmental estrogens, the primary pathway for estradiol production is via the conversion of testosterone by aromatase. This means that the aromatase enzyme binds to testosterone and chemically converts it to estradiol. Think about that for a minute. Realize that this conversion is a double whammy. In one process you're losing T and gaining E. Obviously this is not good.

This is where aromatase inhibitors (AI) like anastrozole (brand name Arimidex - aka "adex" etc.) come into the picture. They bind to the aromatase enzyme and prevent it from converting your testosterone to estradiol. They do not work directly on estradiol nor on estrogen receptors. It is SERM's like Clomid and Nolvadex that bind to estrogen receptors. SERM's and AI's are different animals, so don't get them confused.

So an AI gives you the double whammy in reverse. It prevents the loss of testosterone to conversion and consequently lowers your estradiol which helps keep your androgen receptors available for testosterone.

E Follows T

Here's where doctors fuck up. They forget that E follows T. As your T levels go up, so will your E levels. If you're not doing something to control your E (like taking an AI) then you aren't really going to get anywhere with higher T levels because your higher E levels are just going to cancel out any beneficial effect from the T. Like I said, your T can't do you any good if all your androgen receptors are bound with estradiol.

For those of us with "age related" low T, this is a serious issue because our bodies are naturally trying to keep T low and E high by pumping out aromatase.

If you're younger and have low T for some other reason, aromatase may not be as much of an issue, but it still matters.

Fat

Fat produces estrogen and aromatase; even in men. If you're carrying extra fat, one of the best things you can do to help your hormone balance is to lose the fat.

In Range does not equal Normal

One of the problems you're likely to face is the problem of doctors believing that any blood test value that is "in range" is "normal" and therefor fine. I wish it was that simple.

Let's look at testosterone values. The range for Quest is 241-847 ng/dL. But those values are derived simply by looking at the values of everyone who has a blood test for testosterone. What's normal for a younger man is to be in the higher end of the range. What's normal for an older man is to be in the lower end of the range. Well low T might be "normal" but that doesn't mean it's good! I may be an older guy, but why should I be happy with low T simply because it's normal? ALL men of all ages should be in the higher end of the range if they want to feel good and perform athletically and sexually as men.

The same holds true for estradiol. The range is 13-54 pg/mL but "normal" young men are at the low end of the range and that's where you want to be as well.

Trust me, if your T is 250 and your E is 50, you may be "in range" for both values, but you aren't going to feel good or have anywhere near the athletic and sexual performance that would have if your T was 800 and your E was 15.

Natural Variation

All populations exhibit variation. The average height for men might be 5' 10" but we all know guys who are much taller and much shorter. This same variation applies to T levels, E levels, and reactions to various therapies. In other words, while the principals I've outlined hold true in general, how they specifically apply to you will vary. Be smart and deal with it.

Ok, that's enough from me for now. This is just a basic primer; there's a lot more to this subject so use this as a springboard to do more research on your own.

Anyway I am no expert. But I don't recall anyone on here talking about Androgen Receptors.

Eminem PM so we can arrange a refund/return of your recent order.
Respectfully
MS

No, you surely are not an expert.. As I suspected, this is bullshit.. ^^ @CensoredBoardsSuck found this:

http://e.hormone.tulane.edu/learning/docking-receptor-binding.html

Hormones, though, only bind to certain, compatible receptor types. Thyroid hormones and each steroid hormone group - the estrogens, androgens, progestins, glucocorticoids (stress hormones), and mineralocorticoids (water and ion-regulating hormones) - have a matching hormone receptor type. For instance, estrogen hormones, like estrone, bind to estrogen receptors (ER); androgen hormones, such as testosterone, bind to androgen receptors; and so on.

But, steroid hormone receptors for each hormone group can occur in several versions that differ in form, function, and location. So, steroid and thyroid hormones are not restricted to interact with only one receptor, in one tissue, to produce one kind of action. The hormones can easily bind and activate several versions of their matching receptor type. An example is the estrogen 17-beta-estradiol. It binds to both the ER alpha and ER beta receptors but not to androgen, progestin, or thyroid receptors.

 

[eminem93]

but as of now, he has given me positive outlook. so i will hope for the best and try to smile.

 

[Marcus]

@eminem93 stop fucking posting and go to bed. Your drunk and typing the same shit over and over. Go to bed bro

 

[mikestrong]

So you don't know.. ^^ Yea, TG's blood work is in the pudding.. What's more concerning here is you're so arrogant you won't even look into an issue with this proof..

What proof, blood word was done which I even chipped in for.
Also the lab max the results. Plenty of VIP have stated they are happy with the results.
Seems like you are trying to ruin a good thing for others
It's obvious you are hating on me. How else can you explain your anger towards me & my service.
I think you should start your own thread complaining about my gear & give the reasons why.
MS

 

[eminem93]

@eminem93 stop fucking posting and go to bed. Your drunk and typing the same shit over and over. Go to bed bro

i just wanna help whoever is stuck in my position in the past. gear helped save my life. try being fuckin at level 200's total t's trying to be fucking somebody in life . it doenst' happen / everyones a fucking cheater who ever made it.

 

[mikestrong]

No, you surely are not an expert.. As I suspected, this is bullshit.. ^^ @CensoredBoardsSuck found this:

http://e.hormone.tulane.edu/learning/docking-receptor-binding.html

Hormones, though, only bind to certain, compatible receptor types. Thyroid hormones and each steroid hormone group - the estrogens, androgens, progestins, glucocorticoids (stress hormones), and mineralocorticoids (water and ion-regulating hormones) - have a matching hormone receptor type. For instance, estrogen hormones, like estrone, bind to estrogen receptors (ER); androgen hormones, such as testosterone, bind to androgen receptors; and so on.

But, steroid hormone receptors for each hormone group can occur in several versions that differ in form, function, and location. So, steroid and thyroid hormones are not restricted to interact with only one receptor, in one tissue, to produce one kind of action. The hormones can easily bind and activate several versions of their matching receptor type. An example is the estrogen 17-beta-estradiol. It binds to both the ER alpha and ER beta receptors but not to androgen, progestin, or thyroid receptors.

More hate & negativity,
You found a link to use against me, well done.

 

[Marcus]

i just wanna help whoever is stuck in my position in the past. gear helped save my life. try being fuckin at level 200's total t's trying to be fucking somebody in life . it doenst' happen / everyones a fucking cheater who ever made it.

Your posts aren't making sense! Stop posting please, it's like talking to a friend back in college who got way too drunk.

 

[johnnyBALLZ]

More hate & negativity,
You found a link to use against me, well done.

Hate? You either posted that bullshit copy/paste to confuse people or you didn't know.. If it's the latter how about thanks for clearing that up?? What's wrong with you?

 

[eminem93]

Your posts aren't making sense! Stop posting please, it's like talking to a friend back in college who got way too drunk.

iv gone thru 2 shoulder injuries. rotatur cuff. i was benching over 300 pounds and went from that to benching fucking nothing barely the bar. do u know how depressing that is? do u know how much it feels liek to be a piece of fucking shit cuz u cant be the person you want to ve in life ?

 

[johnnyBALLZ]

What proof, blood word was done which I even chipped in for.
Also the lab max the results. Plenty of VIP have stated they are happy with the results.
Seems like you are trying to ruin a good thing for others
It's obvious you are hating on me. How else can you explain your anger towards me & my service.
I think you should start your own thread complaining about my gear & give the reasons why.
MS

I'm not angry, I'm just trying to open your eyes.. You seem very unhappy with me at the moment though..

And I'm sure TG is happy with his results, 5800 TT is a hell of a number just not for 950mg/week..

 

[Marcus]

iv gone thru 2 shoulder injuries. rotatur cuff. i was benching over 300 pounds and went from that to benching fucking nothing barely the bar. do u know how depressing that is? do u know how much it feels liek to be a piece of fucking shit cuz u cant be the person you want to ve in life ?

Dude, put the fuckin bottle down and go to sleep. Do you even remember that you were originally upset because MS was going to refund you your shit? Then you got upset because you wanna help people with TRT and now because of your shoulder injury and you think your depressed. When really you are coming off benzos and drinking yourself stupid and posting about DUMBASS shit on Meso.

GO THE FUCK TO SLEEP!!

 

[tileguy123]

Ever source here has spoken out of character at one point or another ... Mistakes do happen from us and the sourxes

What proof, blood word was done which I even chipped in for.
Also the lab max the results. Plenty of VIP have stated they are happy with the results.
Seems like you are trying to ruin a good thing for others
It's obvious you are hating on me. How else can you explain your anger towards me & my service.
I think you should start your own thread complaining about my gear & give the reasons why.
MS

Hey Mike - I dont think JB is hating.. he just is not satisfied with the one study you posted about the androgen receptors being blocked from Test by elevated e2... JB and others are here to insure things are kept on the up and up, and often times the way its done feels like a shake down or dis repectful we have all learned it is to keep us safe, and most importantly healthy. Im sure some of the longest standing sources have done people wrong it just comes with the trade. SO like i say i dont think he is coming at you for any reason out of the ordinary Meso , ''Get to the bottom of this shit'' type of way.. So if some members thought that a personal info post hit the thread, or that their may be an issue with the raws.. or dosing.. then im sure itll air out in a fashion that sometimes isnt very nicely presented.. but thats where you suprise us with your gracious repsonses.. instead of defensive.. The best thing in this snearaio is to take a breath, and find the truth, the rational answers... Thats why you havent seem me complain once about low TT numbers for my dose.
Im happy to get my e2 under control , and follow jab guidlines and retest.. asap..
Im also glad to have you here MS. . .

 

[mikestrong]

I'm not angry, I'm just trying to open your eyes.. You seem very unhappy with me at the moment though..

And I'm sure TG is happy with his results, 5800 TT is a hell of a number just not for 950mg/week..

I posted what I know & have read on Receptors.

You find another study that says something diff, then you are the expert & yours is right?

So I think we could use others to search for studies to see what comes out, instead of just saying JB, has it right.
Unhappy with you, just don't get why you would tell me how I should react to safety issues, and basically taking BM side of the story, when safety is at stake & also a scamm situation. I thought you where for the community.

If the numbers are bad, according to you, maybe you should call for a vote in a NEW THREAD to have me removed from here. You sure make it sound like you run things on here.

mikestrong

 

[CensoredBoardsSuck]

Your posts aren't making sense! Stop posting please, it's like talking to a friend back in college who got way too drunk.

iv gone thru 2 shoulder injuries. rotatur cuff. i was benching over 300 pounds and went from that to benching fucking nothing barely the bar. do u know how depressing that is? do u know how much it feels liek to be a piece of fucking shit cuz u cant be the person you want to ve in life ?

 

[eminem93]

im going to run MS shit full blast. YOU GUYS TELL ME WHEN YOU WANT FUCKING BLOODWORK. I WILL DO IT> ont the spot. pick a fucking spot, and i will do it. Im straight with peopel who are straight with me.

 

[eminem93]

iv already done pre bloods, post bloods, i know how shit is.

 

[Big Mike]

iv already done pre bloods, post bloods, i know how shit is.

Bro! Stop it!

 

[tileguy123]

GOD DAMN that ignore button is getting close..

 

[johnnyBALLZ]

I posted what I know & have read on Receptors.

You find another study that says something diff, then you are the expert & yours is right?

So I think we could use others to search for studies to see what comes out, instead of just saying JB, has it right.
Unhappy with you, just don't get why you would tell me how I should react to safety issues, and basically taking BM side of the story, when safety is at stake & also a scamm situation. I thought you where for the community.

If the numbers are bad, according to you, maybe you should call for a vote in a NEW THREAD to have me removed from here. You sure make it sound like you run things on here.

mikestrong

No it's not a study, it's a real article with many references published by a university.. What you posted was something some half brain made up, certainly not a study..

I thought you were different Mike but how you've acted tonight shows you're just here to line your pockets like every other source with no interest in the truth..

Goodnight..

 

[mikestrong]

Ever source here has spoken out of character at one point or another ... Mistakes do happen from us and the sourxes



Hey Mike - I dont think JB is hating.. he just is not satisfied with the one study you posted about the androgen receptors being blocked from Test by elevated e2... JB and others are here to insure things are kept on the up and up, and often times the way its done feels like a shake down or dis repectful we have all learned it is to keep us safe, and most importantly healthy. Im sure some of the longest standing sources have done people wrong it just comes with the trade. SO like i say i dont think he is coming at you for any reason out of the ordinary Meso , ''Get to the bottom of this shit'' type of way.. So if some members thought that a personal info post hit the thread, or that their may be an issue with the raws.. or dosing.. then im sure itll air out in a fashion that sometimes isnt very nicely presented.. but thats where you suprise us with your gracious repsonses.. instead of defensive.. The best thing in this snearaio is to take a breath, and find the truth, the rational answers... Thats why you havent seem me complain once about low TT numbers for my dose.
Im happy to get my e2 under control , and follow jab guidlines and retest.. asap..
Im also glad to have you here MS. . .

Yeah sure lets get more studies out there. I have nothing against that.
VIP TILEGUY, some have expressed that I am against MEMBERS posting up.
I think it would be fair if you mentioned that I did chip in something for this to be done & also mention I never ever was against the testing of my items.
I think JB could leave out the Daughter comments & taking sides on issues of my safety, which in reality he should care about.
As much as he cares for others on here, unless he has something against, which is what I am saying & feeling.
Cause if he does, then it needs to cleared up, as he is on here making comments with a BIASED against me.
mikestrong