How to produce freezing dry hgh/peptides vials from APIs raw powder?
If you need to produce 15,000-20,000 vials per month,,suggest to fill the vials by manual(The sub-machine is the three functions of adding liquid, semi-plugging and capping,it costs about 15K-70K USD,filling 1200-3800vials per hour, at the starting,more machines means more maintenance jobs )
You will need some beakers, measuring cylinders, 4-5 pipette guns. Look it up on amazon or somewhere. The water used for dissolve the raw powder,you can buy the pure water from supermarket(specific conductance under 1.5 uS/cm), you should choose it carefully. When you amount is big enough, you can buy a pure water machine.
Regarding sanitary conditions, first of all, the room can not have Windows, and the floor is clean. Prepare a super clean table. The room of the freeze-dryer should be ventilated, because the oil pump has a smell.
The most important thing is washing bottles, an ultrasound machine, and an oven. The oven needs to reach 250 centigrade degrees for two hours. Basic endotoxin was absent
These require some basic knowledge of laboratory aseptic operation
Buy one set 1 square mater freeze-drying machine (1.5x1.5x2 meters in size ), about 30,000 USD, and flow with a vacuum pump ,you can do the pre-cooling, freeze-drying, vacuum plug in one operation , it needs 24-36 hours, out of about 5,000 bottles.
The rest is gloves, alcohol ,caps pressing forceps(4-5 pcs) and all that stuff .