malfeasance
Well-known Member
IGF-I stimulates proliferation, whereas T3 induces hypertrophic differentiation (115). The fact that T4 is also active in this system is noteworthy. T4 is a prohormone that is converted to T3 by 5′-DI type 1 in peripheral tissues. GH stimulates conversion of T4 to T3 (116, 117), suggesting that some effects of GH may involve this pathway.
Interactions between GH, IGF-I, Glucocorticoids, and Thyroid Hormones during Skeletal Growth - Pediatric Research
Linear growth occurs during development and the childhood years until epiphyseal fusion occurs. This process results from endochondral ossification in the growth plates of long bones and is regulated by systemic hormones and paracrine or autocrine factors. The major regulators of developmental...
www.nature.com