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[iris]

Lab work was done through my primary so was limited in what they would order.

Wouldn't that be part of a routine hormone panel, though?

 

[readalot]

I’ll order this and get back to you. Lab work was done through my primary so was limited in what they would order. Now having more questions I’ll order additional labs independently and try to get it sorted out.

You'd need to understand how your SHBG has changed over time. All else being equal (which it ain't), SHBG will set your Total T for a given weekly dose. Hence if your "multiplier" has changed over time, that's one place to look.

A simple experiment to demonstrate is run constant dose of Test and do a stint of oxandrolone or stanozolol. SHBG will drop and so will Total T while free T stays about the same.

SHBG will also drop over time for those using exogenous androgens consistently.

Make sure you are using LCMS assay for Total T. No interference with other androgens.

 

[Elvis755]

Wouldn't that be part of a routine hormone panel, though?

My doctor ordered metabolic panel, cbc, total test, e2, tsh, GGT, CRP. A1c, lipids. Its not an endocrinologist so they don’t typically go in depth on sex hormone testing.

 

[Ghoul]

Is there some kind of condition I could have that would change the way I respond to exogenous test? I previously had similar numbers to you. Now I’m barely cracking 1200 on 750mg of test. I’m not calling the gear underdosed I’m genuinely curious what is going on with me. I haven’t lost tissue or strength it’s just bizarre to me.

Testosterone metabolism can vary greatly from one individual to another. One factor, for instance, are certain genetic mutations.

There's a genetic test that can identify these factors. It's $1500+ last I checked.

Here's one of the rare looks into this condition:

Genetic Polymorphisms Related to Testosterone Metabolism in Intellectually Gifted Boys - PMC

Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and ...

pmc.ncbi.nlm.nih.gov

 

[Elvis755]

You'd need to understand how your SHBG has changed over time. All else being equal (which it ain't), SHBG will set your Total T for a given weekly dose. Hence if your "multiplier" has changed over time, that's one place to look.

A simple experiment to demonstrate is run constant dose of Test and do a stint of oxandrolone or stanozolol. SHBG will drop and so will Total T while free T stays about the same.

SHBG will also drop over time for those using exogenous androgens consistently.

Make sure you are using LCMS assay for Total T. No interference with other androgens.

That’s something I’ve been curious about the lcms. Would other androgens make the total lower?

 

[readalot]

My doctor ordered metabolic panel, cbc, total test, e2, tsh, GGT, CRP. A1c, lipids. Its not an endocrinologist so they don’t typically go in depth on sex hormone testing.

If you wanted to get to bottom of this just pull TT by LCMS and SHBG. You could order FT using ED+LCMS but shortcut using Vermeulen calculated FT about as good.
Of course you'd have to know where your SHBG used to sit back when "multiplier" was higher.

 

[B Ware]

Is there some kind of condition I could have that would change the way I respond to exogenous test? I previously had similar numbers to you. Now I’m barely cracking 1200 on 750mg of test. I’m not calling the gear underdosed I’m genuinely curious what is going on with me. I haven’t lost tissue or strength it’s just bizarre to me.

There are quite a few factors that are known and probably even more unknown things that affect one’s testosterone levels score. Timing, diet deficit, saturated cells, carrier oil, other aas in combination, etc

Hell, when I pick up my prescription testosterone from the pharmacy if they hand me the brand West Ward I absolutely refuse to take it and will hand it right back to them. Unsure why but it gives me pip and my T score is at a 4-6x multiplier when I take it. Other than that I’ve seen my score significantly lower when in a deficit.

If you have access to a pharmaceutical testosterone maybe try that to compare and see if it makes a difference. Most pharma testosterone is in cottonseed oil and hell maybe that will change your score. Most say gso and cso are nearly identical. I truly believe that’s bullshit. It’s why I actually am using Opti’s test cyp for my trt currently. His gso is smooth where every brand I’ve used with cso leaves a small lump and the oil needs warmed to even pin it.

 

[readalot]

That’s something I’ve been curious about the lcms. Would other androgens make the total lower?

Direct interference with IA assay would inflate TT while other androgens like 17-aa would acutely decrease SHBG (via liver) and hence lower TT. In short it's complicated depending on the other androgen. That's why it pays to cover all the moving parts and of course very few really care to do it. Best wishes and great questions.

 

[Elvis755]

If you wanted to get to bottom of this just pull TT by LCMS and SHBG. You could order FT using ED+LCMS but shortcut using Vermeulen calculated FT about as good.
Of course you'd have to know where your SHBG used to sit back when "multiplier" was higher.

Thank you I’ll order these from Marek. My reason for posting is not to imply the source isn’t reputable. The easiest scenario for me would be the gear is underdosed I switch and move on but my guts been telling me it’s deeper than that so I appreciate the input.

 

[readalot]

And other great points by B Ware. The nitty gritty details on what determines your free T vs dose comes down to (1) clearance and (2) volume of distribution. Together they set your apparent elimination rate constant. If you search on here @Elvis755 there's a bunch of posts gathering dust (or see Excelmale where there's a lot of detail posted).

Search results for query: Clearance

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