For those interested, here is the technical reason for the differences between generic and brand name drugs.
Long story short... the chemical structure is the same. It's the exact same drug. However, the added fillers and such can create a difference in rates of absorption.
In the bloodwork, the levels of the drug in your system will be biologically equivalent, however, they may not be therapeutically equivalent due to the different rate of absorption.
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Looking at this example above as already analyzed by the FDA... you can see that the generic version of Wellbutrin, Budeprion, has a similar area under the curve. The FDA has deemed this biologically equivalent and the 300mg generic drug was placed on the market. However, after usage on the market and many complaints of not being effective, it was determined to not be therapeutically equivalent in a later study done by the FDA to confirm the validity of the complaints. Looking at the curve, you can see why it may not be therapeutically equivalent, despite being biologically equivalent and an equivalent dose of 150mg of each.
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"Citing difficulty recruiting subjects, the company never performed the tests. Then in 2010, the FDA took the unusual step of conducting its own independent trial of 24 subjects. It found that the maximum concentration of Budeprion XL 300 in the blood plasma reached only 75 percent of the amount Wellbutrin XL 300 released, and, in some volunteers, the level never reach 40%. This discrepancy in dosage could render the drug less effective in treating depression and could explain the side effects we were hearing about, Graedon said.
When results of the trials became available in 2012, FDA allowed the products to remain approved but reclassified them as not equivalent to Wellbutrin XL 300. However, the FDA sent both Teva and Impax communications asking them to voluntarily withdraw the drug from the market. Both companies complied with the request. It is unclear if any other national markets demanded a withdrawal of these products."
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Tricky subject we have here with PS because the core compound, tadalafil, will be exactly the same as name brand Cialis... however, the fillers and such added could create a different rate of absorption which create a different therapeutic effect.
Essentially, PS is not cheating anyone on the cialis or doing anything wrong. The compound is just not matching the absorption rate as name brand Cialis. You are still getting the correct amount of drug that you purchased, which his lab reports confirm.
I hope this helps you guys understand...
If anyone would like to read further into this, attached is a reference.
