Pitavastatin and Lp(a)

[Ghoul]

Wait statins affect insulin sensitivity? That's news to me. Ok, so 40mgs of lipitor might affect insulin sensitivity by how much? A lot?

I’ll be lazy:



Long term use of Crestor pushes some prediabetics over the edge into diabetes.

 

[Methyl Mike]

I’ll be lazy:

View attachment 369042

Long term use of Crestor pushes some prediabetics over the edge into diabetes.

Well I'm taking care of a friend who is 87 and has type2 along with CHF. I daresay putting him on lipitor was dumb, and his PCP agreed and wanted to put him on a new statin and so I'm thinking pitavastatin might work. My thinking was nothing to do with diabetes though I was looking at lipitor and it's ability to enter muscle tissue as the primary reason as my friend has typical sides leg pain brain fog muscle weakness and such. But I am not surprised here.

Fwiw between his CHF meds and me working with him via resistance training, a very custom tailored diet and r-ala and berberine his blood sugar has come down from 180s in September (last hospitalization, which was what prompted me to work with him) to 90 as measured a few days ago. My hope/theory is that keeping his blood sugar controlled his heart will improve.

 

[Ghoul]

Well I'm taking care of a friend who is 87 and has type2 along with CHF. I daresay putting him on lipitor was dumb, and his PCP agreed and wanted to put him on a new statin and so I'm thinking pitavastatin might work. My thinking was nothing to do with diabetes though I was looking at lipitor and it's ability to enter muscle tissue as the primary reason as my friend has typical sides leg pain brain fog muscle weakness and such. But I am not surprised here.

Fwiw between his CHF meds and me working with him via resistance training, a very custom tailored diet and r-ala and berberine his blood sugar has come down from 180s in September (last hospitalization, which was what prompted me to work with him) to 90 as measured a few days ago. My hope/theory is that keeping his blood sugar controlled his heart will improve.

Pitavastatin’s main selling point is that it’s a statin for people who can’t tolerate other statins. It has an extremely low risk of any side effect, doesn’t harm insulin sensitivity (some studies suggest it improves it). It’s slightly less potent at lowering LDL in some, but that’s a worthwhile tradeoff for the safety profile.

 

[RockyP]

Pitavastatin 4 mg and Zetia 10 mg had my Lp(a) undetectable, ApoB low 50’s, and LDL at 33 on test, tren, masteron, and anavar (a stack that is known to cause severe dyslipidemia). Zero side effects.

 

[Methyl Mike]

Pitavastatin’s main selling point is that it’s a statin for people who can’t tolerate other statins. It has an extremely low risk of any side effect, doesn’t harm insulin sensitivity (some studies suggest it improves it). It’s slightly less potent at lowering LDL in some, but that’s a worthwhile tradeoff for the safety profile.

I'll run it by his PCP. They are giving it to him to stabilize plaque and lower inflammation I believe.

 

[RockyP]

I'll run it by his PCP. They are giving it to him to stabilize plaque and lower inflammation I believe.

vascepa can assist in this as well and while
Not as potent as a statin it’s also a harmless / side effect free cardiac protector (it’s fish oil).

 

[Ghoul]

I'll run it by his PCP. They are giving it to him to stabilize plaque and lower inflammation I believe.

Be prepared, they’re unlikely to be familiar with it, or think it’s still $500/mo (it’s a cheap generic now).

Consider showing them the info here (click the >65 years old and any other section that’s relevant

Patients Who May Benefit

What are the most common patient characteristics who may benefit from Zypitamag® (pitavastatin)? Check out this page and learn more.

www.zypitamag.com

 

[BP_6]

Lol, that funny I didn't know that. So AAS tanks HDL, and ultra tanks apo(a)?

 

[Methyl Mike]

Be prepared, they’re unlikely to be familiar with it, or think it’s still $500/mo (it’s a cheap generic now).

Consider showing them the info here (click the >65 years old and any other section that’s relevant

Patients Who May Benefit

What are the most common patient characteristics who may benefit from Zypitamag® (pitavastatin)? Check out this page and learn more.

www.zypitamag.com

I will try. Kaiser has been a big letdown honestly. Sad, because my friend looks at them like they saved his life or something. They barely give him the time of day. Yet he obeys with his deer In headlights expression. He didn't give me the time of day for years and only recently after his fourth or fifth trip to the ER and weeks long stay at the hospital did he begrudgingly listen. And of course now he's my sole responsibility I have to do everything for him. Pain in my ass.

 

[Ghoul]

Lol, that funny I didn't know that. So AAS tanks HDL, and ultra tanks apo(a)?

AAS tanks Lp(A), which is now seen as the next biggest lipid risk factor for cardiovascular disease after LDL.

With reductions of Lp(A) of up to 59%, this technically makes Testosterone the most effective FDA approved drug for treating Lp(A) lol.



Even if you control your AAS increased LDL with statins or other compounds, you still get the benefit of AAS lowering Lp(A).

You could argue that for those with high Lp(A), if you keep LDL down while on AAS, you may be at a lower risk for cardiovascular disease than when you’re natural….

 

[rxzed]

Pitavastatin 4 mg and Zetia 10 mg had my Lp(a) undetectable, ApoB low 50’s, and LDL at 33 on test, tren, masteron, and anavar (a stack that is known to cause severe dyslipidemia). Zero side effects.

I got the same results on that exact cycle minus the masteron. Only used 2mg pitavastatin 3x week and 90mg bempedoic acid and 5mg ezetimibe combo pill 3x/week (alternate days).



Going to try bemp/ezet ED dosing and see how much it changes it, then try 4mg pitavastatin ED. Might get some rosuvastatin too to experiment with it.

Edit: Also, worth mentioning that 5mg eztemibe is clinically equivalent to 10mg, though Bempedoic seems to be dose responsive so splitting the combo pill wouldn't be the most ideal

 

[Methyl Mike]

Ya'll make @Millard proud I mean just look at what this forum has accomplished over the years. This idea of his, harm reduction, has absolutely changed the global AAS using community in a huge way. A labor of love no doubt as I highly doubt he has made a dime from meso. Back in the day us idiots were guinea pigging how high we could go with everything, and now young guys are so much more educated and responsible. I am very impressed. If the world were fair he would get some kind of recognition for his effort.

 

[cousinmuscles]

Ya'll make @Millard proud I mean just look at what this forum has accomplished over the years. This idea of his, harm reduction, has absolutely changed the global AAS using community in a huge way. A labor of love no doubt as I highly doubt he has made a dime from meso. Back in the day us idiots were guinea pigging how high we could go with everything, and now young guys are so much more educated and responsible. I am very impressed. If the world were fair he would get some kind of recognition for his effort.

I agree but unfortunately this information is available in this small bubble. I do hope this spreads though, and I make a lot of effort in explaining to close friends and show the research behind it, not just as small talk but to change both behaviour and outlook.

Here are my results after 4 weeks on 4mg pitavastatin and 10mg ezetimibe daily. This was also during the last 4 weeks of my cycle, in which the total compounds and doses were at their highest; 700mg test e, 490mg primo e, 490mg NPP, 140mg MENT.

Genetically I have low lipid levels. Off cycle my LDL, triglycerides, cholesterol et.c. is at the bottom range. With test primo and NPP, with primo being the biggest culprit, HDL becomes undetectable for the labs machine, LDL rises up to above mid range. Barring HDL, my lipids are much better than being off cycle.

I am also on 3g EPA+DHA and 2g niacin daily since many years ago.