What do you propose would explain why shorter esters cause more pip, and that compounds that more easily crash often also cause more pip? I don’t see any issues in my logic based on the solubility properties of these compounds, I’d love to hear your explanation.
Theories are good and all but as said it's mostly "broscience" at that point.
In my opinion, which would be broscience with some logic, short esters cause more PIP due to the fact there is more active hormone per ml of suspension, which would also lead to it having more of a susceptibility to crash out of suspension. As we all know (or should know) the amount of hormone per 100mg of weight is directly related to how short and long the ester is, or if there is no ester at all.
There is also the point of no return to which you've attempted to suspend too much compound per mL which would aid in it's susceptibility to fall out of suspension, and higher concentrations of active compound per mL are noted to have more PIP due to the concentration itself.
Most "products" that are blends labeled at higher than 400mg in my opinion are bogus. It's insanely difficult to suspend that much compound per mL. Had that conversation with numerous people. An I mean you can't really prove that wrong without sending your illegal substance in for testing, which 99.9% of people won't do. You can do a bloods comparison to the supposed amount of product you're using but that's only as good as a prior tested compound at a specific dosage, and your best bet is a pharmaceutical grade (actual prescription) suspension to use as baseline. But if someone's selling a blend over 400mg I'd never trust it, let alone risk the PIP if they actually suspended that much shit in 1mL.
Your typical rip blend 300
Test 80mg
Tren 83mg
Mast 80mg
Per mL 243mg active
Typical example long ester blend 300
Test C 104mg
Deca D 96mg
Per mL 200mg active
Longer ester weights are known to be more oil soluble, where as shorter ester weights or non ester are not as soluble. Which would corroborate your ester theory on oil solubility, but it does not make a claim to "crystallization" in the muscle. Ester weights simply get broken down by enzymes which release the hormone at a given rate. No ester, no slow release. I've used test suspension with 0 PIP.
PIP can be related to numerous things. Ester compound causing irritation themselves, Concentration, whatever was used to suspend said compound (EO, MCT, GSO, CSO, SSO), what they used as far as a ratio of BA/BB. Simply miscalculating your BA can cause severe PIP. Some people react badly to different carriers, I myself have to avoid EO like the plague.
Hormones do not crystallize with heat (unless in an open state to dehydrate with substantial heat), they will on the other hand crystallize with cold. Hormones can use any form of moisture to solvate, which, your body is how much water exactly?
On the other hand. Hormonal pellet implantation as a form of TRT is literally a crystalline implant with no solvent or carrier, except your tissue. The only related "soreness" to that is from the procedure itself due to the fact they shoving pellets into you with a big ass injector.
So.....long story short, TLDR, no, suspended hormones won't "crystallize" in your body, and even if they did, it's not what causes PIP (in my opinion).
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