Qingdao Sigma Chemicals
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Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
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Docsunshine23
Member
Are these sold out or just mean they best selling?
Qingdao Sigma Chemicals
Subscriber
Best selling
Ghoul
Well-known Member
Yes. The major commercial peptide suppliers in the US advise .2 micron filtration can be used if sterilization of reconstituted solution is desired, which indicates, at least at that filter size, peptides of all lengths will pass. Protein adhesion varies between filter materials, so its worth checking to ensure your filter type isn't "high protein adhesion", few are though.
Here's something very interesting I came across regarding peptide filtration.
"Protein aggregates", folded and clumped proteins. aka DIMER:
1: Can cause an immune response, leading to any number of side effects. Several peptide drug trials in the last few years failed due to immunogenicity. They detected an immune reaction and stopped the trial. It's now believed this was caused by dimer formed by #2
2: Chemicals leaching from the stopper coring fragments, and especially silicone, cause peptides to clump into aggregates, ie, dimer.
3: Peptide aggregates can be filtered out. Thereby avoiding potential side effects. Several proposals suggest "bedside filtration" of peptide based drugs just prior to injection for improved patient safety. and better outcomes from the compound.
This is from a peptide vial that appears clear to the naked eye.
Personally I find the potential to clear out defective, possibly side effect inducing, malformed protein lumps from reconstituted peptides, and improving their performance, a very exciting possibility. I'd love others to research this topic and see what they can come up with as well.
Last edited:
egruberman
Well-known Member
What filters are you using to draw up the peptide? I'm presently pushing up my HGH dose as high as I can until I get sides. It would be interesting to see if I could tolerate a larger dose with filtration.
Docsunshine23
Member
This is very interesting and I am going to go down the rabbit hole tomorrow on this subject.
It would be interesting to find out if we could essentially filter out dimer that is present in the HGH on testing, essentially being able to create dimer free HGH regardless of the purity
Ghoul
Well-known Member
I want to stress I can't be sure this size isn't inadvertently blocking peptide, so I'm not advising anyone to use .1um for peptides. But thus far, I've noticed no reduction in potency from the 3 peptides I've used with it so far. .2um is the smallest officially sanctioned filter for peptide use.
It's only "feels", but the MT-2 batch I was using always caused pip and redness. That isn't happening any more.
I attach these (there are less expensive alternatives, I got a small bag as surplus):
High Flow Syringe Filter, PES, 0.1 µm | Sartorius
Optimize your filtration process with Minisart® Syringe Filter. High flow rate, sterile, and ready-to-use. Removes mycoplasma and provides low non-specific binding. Bidirectional use possible. Get yours now!
To a vented, filterless BD vial spike:
Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates - PubMed
Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...
pubmed.ncbi.nlm.nih.gov
It’s seized by the men in black, now you have to wait for your anal probing for intergalactic smuggling.
Benf15harp
Member
I figured.
Bigbicep
Member
Don’t be a pussy and just shoot it in the bum mate
Very cheap! Just 165 euro for 50 filter, 3 euro a filter. A steal!I want to stress I can't be sure this size isn't inadvertently blocking peptide, so I'm not advising anyone to use .1um for peptides. But thus far, I've noticed no reduction in potency from the 3 peptides I've used with it so far. .2um is the smallest officially sanctioned filter for peptide use.
It's only "feels", but the MT-2 batch I was using always caused pip and redness. That isn't happening any more.
I attach these (there are less expensive alternatives, I got a small bag as surplus):
High Flow Syringe Filter, PES, 0.1 µm | Sartorius
Optimize your filtration process with Minisart® Syringe Filter. High flow rate, sterile, and ready-to-use. Removes mycoplasma and provides low non-specific binding. Bidirectional use possible. Get yours now!shop.sartorius.com
To a vented, filterless BD vial spike:
View attachment 296222
Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates - PubMed
Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...
egruberman
Well-known Member
If I tried it with GH and observed a reduction in side effects for the same volume, that could easily be filtered peptide. I suppose I could inject the same volume both filtered and non and then get a serum GH test.
So this filter goes on top of peptide vials? And you just use it for the entire vial or do you use one for each dose? Just wandering bc I’ve never used one and taking a lot more peptides these days so if this really works as marketed, this is huge for harm reduction especially with all the peptides out and the amount and variety which is used. So anyone with any experience please chime in bc I have a lot of gh, tirz, bpc, and tb5 I would definitely use it on. One more question, wouldn’t you also lose a good amount in the filtering process. If no one really knows this seems like one hell of a good test for jano to experiment with. Take a dose from the vial and from filter top and compare results suck as purity and dimer and potencyI want to stress I can't be sure this size isn't inadvertently blocking peptide, so I'm not advising anyone to use .1um for peptides. But thus far, I've noticed no reduction in potency from the 3 peptides I've used with it so far. .2um is the smallest officially sanctioned filter for peptide use.
It's only "feels", but the MT-2 batch I was using always caused pip and redness. That isn't happening any more.
I attach these (there are less expensive alternatives, I got a small bag as surplus):
High Flow Syringe Filter, PES, 0.1 µm | Sartorius
Optimize your filtration process with Minisart® Syringe Filter. High flow rate, sterile, and ready-to-use. Removes mycoplasma and provides low non-specific binding. Bidirectional use possible. Get yours now!
To a vented, filterless BD vial spike:
View attachment 296222
Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates - PubMed
Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...
narta
Member
It's getting fucking ridiculous....
don't interrupt the clown show please
No! 2800 pages and no one’s order international to Australia. Your border too tough It’s way too good of a deal for gh I would go get the expensive stuff that’s better!!
You're strange mate. I said recently...I've ordered a few times internationally last year and had a couple of seizures so I'm asking for feedback about people that have ordered RECENTLY. No need to be a smart ass
Just a joke not dick don’t take it so hard!.. really though I’ve heard Australia is getting to hard to get a lot of shot through lately
Dirthand
Well-known Member
Always a need!!! Always.. just take it with smile.. no need to get pissy.
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