Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[DeeX]

Retatrutide definitely makes you feel hypo. I’m only on 3.25mg and it makes me feel bad.

Felt the best on tirz. I wanted to try reta for liver health as I am a recovered alcoholic and wanted to cut down hard and use the glucagon agonism to rid any fatty liver left over.

Tirz doesn’t do much for hunger until you get up to 5+mg (for me). Also the anti-inflammatory effects of tirz are better. I lost a bit of lean tissue with reta. (Dieting on true HRT)

If I were a generally healthy bodybuilder….id do this…..

Start with Dash of semaglutide for the hunger blunting…even .25mg might be enough, paired with 2.5mg Tirz for the GIP agonism which helps nausea, and somehow enhances the anti inflammatory effects. Some might need .5mg/5mg…but I went that high and 2400 calories was requiring whey and rice Chex shakes

And this will be more cost effective than straight tirz

Phase 3 trial dosage is 2,4,6,9,12.

 

[Letits now]

Liver?

I did have some fatty liver issues but I had attributed that to the phenibut I was taking for a while. Plus I was 50 pounds heavier.

 

[BamaCrazy]

Heart rate increase

My resting HR went from 57 to 64 on Reta. Even higher would be a safe number.

 

[BP_6]

I have always carried the extra in the gut. Started tirz and got the result I wanted. Titrated down and kept the eating clean. It still came back. Started pinning again and it went away. Then started reading about anti-inflammatory benefits.
So the affect may be anecdotal but I assumed it is related to the tirz.
And it’s not just fat. It’s almost like there’s some swelling.

Thanks for the explanation. I asked because I on occasion have the same issue and it was even verified with a CAT scan as minor non specific inflammation. Which is funny because you read gut swelling can be a side effect of tirz so who knows. I might give it a try just to see.

 

[DeeX]

Yea so considering how many people have reported no appetite control with retatrutide while cutting weight drastically by what mechanism would that happen? Personally only now joining the hype train ironically thanks to Chase Irons particularly interested by the gut health, blood sugar changes etc. but recomposition is welcome, people experienced with the 3 what would you say the main benefit is to retatrutide?

I've been on 12 for a couple months now.

Took about 6 weeks to kick in...and when it does, it kicks in hard. I haven't been hungry on Reta since second week of 4 mg.

I wear a CGM now bc I went hypoglycemic when on Ozempic originally earlier this year (<30 glucose).

Context for rest of post: 1200 calories per day max, high protein low carb diet, supplementing with multivitamins, blood tests every few weeks to confirm everything is going perfectly.

Semaglutide experience: okay, hunger would come back end of every week, insane constipation + burping + acid reflux. HRV absolutely tanked, but stayed on it until hitting 1.7. Lost ~1/ lbs per week. Fatigued like crazy.

Tirzepatide: great, burping continued, but other side effects were mildly existent...laxatives + electrolytes made everything better. Titrated up to 10 mg, was losing 1.5 lbs/week.

Retatrutide: excellent, all side effects have gone away aside from burping. I do wake up middle of the night needing to chug water and am needing to drink electrolytes multiple times per day. On 12 mg dose, losing ~3.5 lbs/week. I am 20 lbs from my goal weight right now and normal weight range, losing weight hasn't slowed though.

Fatigued lasted a couple weeks on Reta, until I started to eat way more protein.

 

[Letits now]

Thanks for the explanation. I asked because I on occasion have the same issue and it was even verified with a CAT scan as minor non specific inflammation. Which is funny because you read gut swelling can be a side effect of tirz so who knows. I might give it a try just to see.

It’s an amazing product.
I’m reading on here to see if there’s a better pairing with the hgh considering the insulin effect.

 

[max187]

I personally get sides from Reta at 9mg per week pinning 3mg Monday/Wednesday/Friday.
I get hyperesthesia. It was manageable but unpleasant enough for me to take 10 days off.
Then this week I went back to reatatrutide and I'm experiencing it again although it's very mild this time. I was going to take another dose tomorrow but I am now considering sticking back to Tirzepetide for this coming week and just swapping compounds each week.

 

[JG91]

Yea so considering how many people have reported no appetite control with retatrutide while cutting weight drastically by what mechanism would that happen? Personally only now joining the hype train ironically thanks to Chase Irons particularly interested by the gut health, blood sugar changes etc. but recomposition is welcome, people experienced with the 3 what would you say the main benefit is to retatrutide?

I found appetite control with reta as good as tirz and I really think the glucagon burns more fat than we think.

After trying both I highly recommend reta over tirz.

 

[BamaCrazy]

I personally get sides from Reta at 9mg per week pinning 3mg Monday/Wednesday/Friday.
I get hyperesthesia. It was manageable but unpleasant enough for me to take 10 days off.
Then this week I went back to reatatrutide and I'm experiencing it again although it's very mild this time. I was going to take another dose tomorrow but I am now considering sticking back to Tirzepetide for this coming week and just swapping compounds each week.

I’ve heard some call it allodynia. People have reported it on all GLPs. I also get it using Reta but didn’t on Tirz. It’s a minor nuisance that fades 2-3 days after injection.

 

[BP_6]

I've been on 12 for a couple months now.

Took about 6 weeks to kick in...and when it does, it kicks in hard. I haven't been hungry on Reta since second week of 4 mg.

I wear a CGM now bc I went hypoglycemic when on Ozempic originally earlier this year (<30 glucose).

Context for rest of post: 1200 calories per day max, high protein low carb diet, supplementing with multivitamins, blood tests every few weeks to confirm everything is going perfectly.

Semaglutide experience: okay, hunger would come back end of every week, insane constipation + burping + acid reflux. HRV absolutely tanked, but stayed on it until hitting 1.7. Lost ~1/ lbs per week. Fatigued like crazy.

Tirzepatide: great, burping continued, but other side effects were mildly existent...laxatives + electrolytes made everything better. Titrated up to 10 mg, was losing 1.5 lbs/week.

Retatrutide: excellent, all side effects have gone away aside from burping. I do wake up middle of the night needing to chug water and am needing to drink electrolytes multiple times per day. On 12 mg dose, losing ~3.5 lbs/week. I am 20 lbs from my goal weight right now and normal weight range, losing weight hasn't slowed though.

Fatigued lasted a couple weeks on Reta, until I started to eat way more protein.

Wow <30 blood glucose. Surprise you didn't pass out. Couldn't have felt too good.

 

[DeeX]

Wow <30 blood glucose. Surprise you didn't pass out. Couldn't have felt too good.

Felt like I was completely plastered when I tried to move at the end of a work meeting. Did a finger test and boom, "<30".

Guess I'm lucky that I'm not diabetic.

 

[LGOP528]

Heart rate increase

HR returns to normal about a week and a half of stopping Reta. At least it did for me.

 

[BP_6]

HR returns to normal about a week and a half of stopping Reta. At least it did for me.

Anyone know through what mechanism it increases HR?

 

[max187]

I’ve heard some call it allodynia. People have reported it on all GLPs. I also get it using Reta but didn’t on Tirz. It’s a minor nuisance that fades 2-3 days after injection.

Not for me. Mine lasted 10 days after my last administration of Reta.
It was very annoying and irritating for 5-6 days. I took ten days off and it subsided.

 

[AnTabolic73]

I intend on staying on tirz indefinitely. Unless price or some long term studies show it is an issue. I'm lowering the dose as I bulk. I'll raise it up when I wanna cut again.

Next year I may wanna try reta. Plan is to introduce it at lowest dose. And slowly lower tirz till it's gone. But this is a plan. It's mainly for curiousity. Part of me is thinking if tirz worked so well why fix something that's not broke.

 

[DugPrime]

I intend on staying on tirz indefinitely. Unless price or some long term studies show it is an issue. I'm lowering the dose as I bulk. I'll raise it up when I wanna cut again.

Next year I may wanna try reta. Plan is to introduce it at lowest dose. And slowly lower tirz till it's gone. But this is a plan. It's mainly for curiousity. Part of me is thinking if tirz worked so well why fix something that's not broke.

You have to cycle it; otherwise, you’ll desensitize your GLP/GLP-1 receptors over time. Why not use it during the cut and switch to metformin during the bulk?

 

[AnTabolic73]

You have to cycle it; otherwise, you’ll desensitize your GLP/GLP-1 receptors over time. Why not use it during the cut and switch to metformin during the bulk?

@Ghoul

Can explain it. But apparently desensitization isn't an issue.

 

[MyNameIsJeff]

this thread right now:

 

[Letits now]

Thanks for the explanation. I asked because I on occasion have the same issue and it was even verified with a CAT scan as minor non specific inflammation. Which is funny because you read gut swelling can be a side effect of tirz so who knows. I might give it a try just to see.

Let us know if it works.

 

[Ghoul]

@Ghoul

Can explain it. But apparently desensitization isn't an issue.

The extended phase clinical trials of both Tirz and Sema, going out 3 and 4 years respectively, clearly demonstrate once a "maintenance dose" is reached, weight loss is durable for years and side effects virtually disappear. If "desensitization" were a thing, they'd regain weight over time.

What has been observed by researchers and clinicians is interrupting GLP use, then returning, even years later, results in a weaker response to the drug, requiring higher doses for the same effect. Each time one of these "breaks" occurs response to the weight loss effect gets weaker, even across different GLP compounds.

The mechanism causing this is unclear, but might explain why in clinical trials 96%+ of participants following "boring" single GLP drug pharma protocols lose massive amounts of weight successfully, but at the Reddit Clinic, the people jumping on and off, switching compounds, injecting 5 times a week, and stacking just can't seem to drop the 10lbs they've been trying to for the last 6 months....