Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

I never said it doesn't work I said the appetite suppression was mostly gone at the same dosages. It was still working for my BG for what I could tell.

That's why for me a good idea is just start using it, ride out the appetite suppression and try to find the lowest dosage where you have no suppression and great BG control and other health benefit, when you wanna cut Increase dosage, when you wanna bulk go back at that precious dosage. End of story
So, basically you’re using it all the time, got it.
 
For what it's worth, there are other medications where breaks in treatment result in seroconversion, that is, the immune system developing antibodies to the drug that can make it less effective when treatment is resumed. The strategy to mitigate this risk is to ensure treatment is as continuous as possible. keeping breaks to an absolute minimum.

I have no idea if that's what's going on here, but the dynamic seems similar.
 
Also, the versions of these drugs we get are synthetic, not the recombinant type created by reprogramming yeast genes like pharma does. This makes the peptides we're using look less like the natural hormones they're mimicking and more "alien" to the immune system. So that may make it easier for the immune system to target and remove them from our body, reducing effectiveness.

The synthetic type also has a different set of after manufacturing contaminants than recombinant, and were never put through human trials like the recombinant versions, so there's yet another set of unknowns.
 
For what it's worth, there are other medications where breaks in treatment result in seroconversion, that is, the immune system developing antibodies to the drug that can make it less effective when treatment is resumed. The strategy to mitigate this risk is to ensure treatment is as continuous as possible. keeping breaks to an absolute minimum.

I have no idea if that's what's going on here, but the dynamic seems similar.
So, is it a proven fact or just another theory? Any actual time frame for these breaks?

Any recommendations or where to find data to read about proper breaks? Also where did you see the data on how effectiveness reduction after cessation.
 
So, is it a proven fact or just another theory? Any actual time frame for these breaks?

Any recommendations or where to find data to read about proper breaks? Also where did you see the data on how effectiveness reduction after cessation.

Declan what do you want? You didn't want studies, you wanted first hand experiences and got them.

Now you don't want theories, you want data. You want certainty, a manual spelling everything out in detail with enough data to eliminate all ambiguity.

All I can tell you is my experience, and of others, who use them continuously and experienced no further drop off in efficacy. We know thousands of closely monitored trial subjects had no drop off in efficacy over the course of years of continuous use, being 2 to 3 years passed any additional weight loss or side effects at the final dose they stayed on permanently. They're not regaining weight.

Do what you want. Go on and off, use whatever protocol. Maybe it'll be just fine. Maybe in a few years there will be some explanation for what's being experienced. Maybe after 25 cycles none of the drugs in this class will work for you ever again, or perhaps your immune system turns on the natural form of GLP and GIP as a result, with some terrible health impact. God knows we have a long list of unintended medicine consequences only discovered after many years.

All I can do; if I'm going to keep using this stuff, is try to minimize my risk from exposure to the unknown by sticking as closely to the methods used that have proven safe for a lot of people over an extended period of time. "Millions of patient years of experience" is the relevant expression. Maybe I've already fucked myself by using a peptide made in the basement of some Beijing dry cleaner. Who knows. We're all a bunch of Magellan's out here. Only time will tell.
 
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Ok gotta remove glp people .. your killing us all..

Right there bud. Hit that button and all past and future posts by the user disappear from view. It's an awesome feature, because it lets you be your own moderator, banning anyone you want from your world here at MESO.

I can relate. Can't stand low effort members, but rather than try to control what others get to read, I just worry about myself and who I don't want to see, and *poof*, they're gone.

IMG_9484.webp
 
Declan what do you want? You didn't want studies, you wanted first hand experiences and got them.

Now you don't want theories, you want data. You want certainty, a manual spelling everything out in detail with enough data to eliminate all ambiguity.

All I can tell you is my experience, and of others, who use them continuously and experienced no further drop off in efficacy. We know thousands of closely monitored trial subjects had no drop off in efficacy over the course of years of continuous use, being 2 to 3 years passed any additional weight loss or side effects at the final dose they stayed on permanently. They're not regaining weight.

Do what you want. Go on and off, use whatever protocol. Maybe it'll be just fine. Maybe in a few years there will be some explanation for what's being experienced. Maybe after 25 cycles none of the drugs in this class will work for you ever again, or perhaps your immune system turns on the natural form of GLP and GIP as a result, with some terrible health impact. God knows we have a long list of unintended medicine consequences only discovered after many years.

All I can do; if I'm going to keep using this stuff, is try to minimize my risk from exposure to the unknown by sticking as closely to the methods used that have proven safe for a lot of people over an extended period of time. "Millions of patient years of experience" is the relevant expression. Maybe I've already fucked myself by using a peptide made in the basement of some Beijing dry cleaner. Who knows. We're all a bunch of Magellan's out here. Only time will tell.
I am just trying to understand based on your experience and others, but since you say it won’t work as well if you keep stopping I am wondering if you know based on your experience when it stops or how it much reduction in efficacy when you reintroduce it again.

My question rises from what you alone experienced, which is different from what Sampei described as for him it’s just the appetite suppression.

Remember I am not a diabetic, I am dabbling at this as a fatloss aid nothing more, hence, I am not planning of using it forever.

And from what I gather off your statements now, I will continue to do so since everyone here are just experimenting when it comes to using it in bodybuilding terms.
 
I am just trying to understand based on your experience and others, but since you say it won’t work as well if you keep stopping I am wondering if you know based on your experience when it stops or how it much reduction in efficacy when you reintroduce it again.

My question rises from what you alone experienced, which is different from what Sampei described as for him it’s just the appetite suppression.

Remember I am not a diabetic, I am dabbling at this as a fatloss aid nothing more, hence, I am not planning of using it forever.

And from what I gather off your statements now, I will continue to do so since everyone here are just experimenting when it comes to using it in bodybuilding terms.
Just my anecdotal experience with Tirzepatide from this source.
By the end i had to go up to 20mg/week to still get any small appetite supressant effects. Blood glucose management still there. Decided to drop all GLP's after reaching 5% bodyfat. Now back at 12%. Started using it again after 5 months because fasted BG getting too high with 8iu gh. Started at out 10mg Tirzepatide, no appetite effects. Fasted BG was in range but not optimal. Just added in 4mg Retatrutide. Now i feel a bit of appetite supressant effects again and good slowing of gastric emptying. Fasted BG fully in range.
 
Just my anecdotal experience with Tirzepatide from this source.
By the end i had to go up to 20mg/week to still get any small appetite supressant effects. Blood glucose management still there. Decided to drop all GLP's after reaching 5% bodyfat. Now back at 12%. Started using it again after 5 months because fasted BG getting too high with 8iu gh. Started at out 10mg Tirzepatide, no appetite effects. Fasted BG was in range but not optimal. Just added in 4mg Retatrutide. Now i feel a bit of appetite supressant effects again and good slowing of gastric emptying. Fasted BG fully in range.
Thanks man good to know.

Another one losing the appetite suppression upon cessation and switching compounds helped.
 
my cycles have been primarily: test, primo, gh, mk677.
Have slightly dabbled with anavar and masteron and some peptides.

Got some anadrol and dianabol just because the promo was insane, otherwise wasn't planning on trying these anytime soon.

Out of the two I was going to try out anadrol for a few weeks during this cycle. I'm thinking I'll go with half of my usual test/primo blast amount + 20mg anadrol a day maybe and see if I like it. Is it decent short term like a few weeks?

Also I just started doing keto again (I imagine there is less aromatising but haven't looked into this. I haven't jumped back in cycle yet but will look into this.

I'm accustomed to a certain amount of primo and test balancing well for me. And I'm hoping it won't be difficult to find a new "sweet balance". Hopefully it's nearly the same.

Any insights on this, any experience on your cycle needs changing after switching to keto vs what you run high carb?

Any raves or complaints on dbol vs anadrol. Im interested in muscle but I really appreciate the high strength of high dosage cycles.

The appeal of orals to me is maybe still getting crazy strength gains without as much total mg of androgens per week. Any experience on expectations being met here or disappointed?

Let's have some steroid bro talk. Let the fatties have their glp talks lol .
 

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